G protein-coupled receptors: structure- and function-based drug discovery

doi:10.1038/s41392-020-00435-w

	G protein-coupled receptors: structure- and function-based drug discovery
	Yang, Dehua 1,2; Zhou, Qingtong 3; Labroska, Viktorija 1,4; Qin, Shanshan5 ; Darbalaei, Sanaz 1,4; Wu, Yiran5 ; Yuliantie, Elita 1,4; Xie, Linshan5,6 ; Tao, Houchao5 ; Cheng, Jianjun5 ; Liu, Qing 1,2; Zhao, Suwen5,6 ; Shui, Wenqing5 ; Jiang, Yi 2; Wang, Ming-Wei1,2,3,4,6,7
	2021
发表期刊	SIGNAL TRANSDUCTION AND TARGETED THERAPY
ISSN	2095-9907
EISSN	2059-3635
卷号	6 期号:1 页码:7
发表状态	已发表
DOI	10.1038/s41392-020-00435-w
摘要	As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design. We are eye-witnessing tremendous progresses made recently in the understanding of their structure-function relationships that facilitated drug development at an unprecedented pace. This article intends to provide a comprehensive overview of this important field to a broader readership that shares some common interests in drug discovery.
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收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
出版者	SPRINGERNATURE, CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
WOS关键词	MS-binding assays ; Selection-mass spectrometry ; Cryo-EM structure ; Crystallizing membrane-proteins ; Molecular-orbital method ; Glucagon-like peptide-1 ; Allosteric modulation ; GLP-1 receptor ; Biased agonism ; Adenosine A(1)
原始文献类型	Review
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/125238
专题	iHuman研究所_PI研究组_水雯箐组生命科学与技术学院_特聘教授组_王明伟组 iHuman研究所_PI研究组_陶厚朝组 iHuman研究所_PI研究组_赵素文组 iHuman研究所_PI研究组_程建军组生命科学与技术学院_博士生
通讯作者	Shui, Wenqing; Jiang, Yi; Wang, Ming-Wei
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 3.Fudan Univ, Sch Basic Med Sci, Shanghai 200032, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 7.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
通讯作者单位	iHuman研究所; 生命科学与技术学院
推荐引用方式 GB/T 7714	Yang, Dehua,Zhou, Qingtong,Labroska, Viktorija,et al. G protein-coupled receptors: structure- and function-based drug discovery[J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY,2021,6(1):7.
APA	Yang, Dehua.,Zhou, Qingtong.,Labroska, Viktorija.,Qin, Shanshan.,Darbalaei, Sanaz.,...&Wang, Ming-Wei.(2021).G protein-coupled receptors: structure- and function-based drug discovery.SIGNAL TRANSDUCTION AND TARGETED THERAPY,6(1),7.
MLA	Yang, Dehua,et al."G protein-coupled receptors: structure- and function-based drug discovery".SIGNAL TRANSDUCTION AND TARGETED THERAPY 6.1(2021):7.