Bioactive Metabolites and Potential Mycotoxins Produced byCordycepsFungi: A Review of Safety

doi:10.3390/toxins12060410

	Bioactive Metabolites and Potential Mycotoxins Produced byCordycepsFungi: A Review of Safety
	Chen, Bo 1,2; Sun, Yanlei 1,2; Luo, Feifei 1; Wang, Chengshu1,2,3
	2020-06
发表期刊	TOXINS
EISSN	2072-6651
卷号	12 期号:6
发表状态	已发表
DOI	10.3390/toxins12060410
摘要	AscomyceteCordycepsfungi such asC. militaris,C. cicadae, andC. guangdongensishave been mass produced on artificial media either as food supplements or health additives while the byproducts of culture substrates are largely used as animal feed. The safety concerns associated with the daily consumption ofCordycepsfungi or related products are still being debated. On the one hand, the known compounds from these fungi such as adenosine analogs cordycepin and pentostatin have demonstrated different beneficial or pharmaceutical activities but also dose-dependent cytotoxicities, neurological toxicities and or toxicological effects in humans and animals. On the other hand, the possibility of mycotoxin production byCordycepsfungi has not been completely ruled out. In contrast to a few metabolites identified, an array of biosynthetic gene clusters (BGCs) are encoded in each genome of these fungi with the potential to produce a plethora of as yet unknown secondary metabolites. Conservation analysis of BGCs suggests that mycotoxin analogs of PR-toxin and trichothecenes might be produced byCordycepsfungi. Future elucidation of the compounds produced by these functionally unknown BGCs, and in-depth assessments of metabolite bioactivity and chemical safety, will not only facilitate the safe use ofCordycepsfungi as human food or alternative medicine, but will also benefit the use of mass production byproducts as animal feed. To corroborate the long record of use as a traditional medicine, future efforts will also benefit the exploration ofCordycepsfungi for pharmaceutical purposes.
关键词	Cordycepsfungi mass production mycotoxins biosynthetic gene cluster toxicity safety
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[31530001] ; Shanghai Academic/Technology Research Leader Program[18XD1404500]
WOS研究方向	Food Science & Technology ; Toxicology
WOS类目	Food Science & Technology ; Toxicology
WOS记录号	WOS:000551188000072
出版者	MDPI
WOS关键词	CORDYCEPS-SINENSIS ; BEAUVERIOLIDE I ; CHEMICAL-CONSTITUENTS ; CULTURE LIQUID ; BIOSYNTHESIS ; TOXICITY ; OOSPOREIN ; TRICHOTHECENES ; CONVERGENCE ; CULTIVATION
原始文献类型	Review
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/122683
专题	生命科学与技术学院_特聘教授组_王成树组
通讯作者	Wang, Chengshu
作者单位	1.Chinese Acad Sci, Shanghai Inst Plant Physiol & Ecol, CAS Ctr Excellence Mol Plant Sci, Key Lab Insect Dev & Evolutionary Biol, Shanghai 200032, Peoples R China 2.Univ Chinese Acad Sci, CAS Ctr Excellence Biot Interact, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Chen, Bo,Sun, Yanlei,Luo, Feifei,et al. Bioactive Metabolites and Potential Mycotoxins Produced byCordycepsFungi: A Review of Safety[J]. TOXINS,2020,12(6).
APA	Chen, Bo,Sun, Yanlei,Luo, Feifei,&Wang, Chengshu.(2020).Bioactive Metabolites and Potential Mycotoxins Produced byCordycepsFungi: A Review of Safety.TOXINS,12(6).
MLA	Chen, Bo,et al."Bioactive Metabolites and Potential Mycotoxins Produced byCordycepsFungi: A Review of Safety".TOXINS 12.6(2020).