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beta-Arrestin-1 Protein Represses Diet-induced Obesity | |
2011 | |
发表期刊 | JOURNAL OF BIOLOGICAL CHEMISTRY |
ISSN | 0021-9258 |
EISSN | 1083-351X |
卷号 | 286期号:32页码:28396-28402 |
发表状态 | 已发表 |
DOI | 10.1074/jbc.M111.223206 |
摘要 | Diet-related obesity is a major metabolic disorder. Excessive fat mass is associated with type 2 diabetes, hepatic steatosis, and arteriosclerosis. Dysregulation of lipid metabolism and adipose tissue function contributes to diet-induced obesity. Here, we report that beta-arrestin-1 knock-out mice are susceptible to diet-induced obesity. Knock-out of the gene encoding beta-arrestin-1 caused increased fat mass accumulation and decreased whole-body insulin sensitivity in mice fed a high-fat diet. In beta-arrestin-1 knock-out mice, we observed disrupted food intake and energy expenditure and increased macrophage infiltration in white adipose tissue. At the molecular level, beta-arrestin-1 deficiency affected the expression of many lipid metabolic genes and inflammatory genes in adipose tissue. Consistently, transgenic overexpression of beta-arrestin-1 repressed diet-induced obesity and improved glucose tolerance and systemic insulin sensitivity. Thus, our findings reveal that beta-arrestin-1 plays a role in metabolism regulation. |
URL | 查看原文 |
收录类别 | SCI |
WOS研究方向 | Biochemistry & Molecular Biology |
WOS类目 | Biochemistry & Molecular Biology |
WOS记录号 | WOS:000293557800055 |
WOS关键词 | INSULIN-RESISTANCE ; ENERGY-BALANCE ; BETA-ARRESTIN ; PPAR-GAMMA ; RAT-BRAIN ; FAT ; ACTIVATION ; PHOSPHORYLATION ; CONTRIBUTES ; SENSITIVITY |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/121994 |
专题 | 个人在本单位外知识产出 |
通讯作者 | Zhao, Jian; Pei, Gang |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China 3.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Diabet Inst, Dept Endocrinol & Metab, Shanghai 200233, Peoples R China 4.Shanghai Clin Ctr Diabet, Shanghai 200233, Peoples R China 5.Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China |
推荐引用方式 GB/T 7714 | Zhuang, Le-nan,Hu, Wen-xiang,Zhang, Ming-liang,et al. beta-Arrestin-1 Protein Represses Diet-induced Obesity[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2011,286(32):28396-28402. |
APA | Zhuang, Le-nan.,Hu, Wen-xiang.,Zhang, Ming-liang.,Xin, Shun-mei.,Jia, Wei-ping.,...&Pei, Gang.(2011).beta-Arrestin-1 Protein Represses Diet-induced Obesity.JOURNAL OF BIOLOGICAL CHEMISTRY,286(32),28396-28402. |
MLA | Zhuang, Le-nan,et al."beta-Arrestin-1 Protein Represses Diet-induced Obesity".JOURNAL OF BIOLOGICAL CHEMISTRY 286.32(2011):28396-28402. |
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