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A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma | |
2015 | |
发表期刊 | MOLECULAR CANCER RESEARCH |
ISSN | 1541-7786 |
EISSN | 1557-3125 |
卷号 | 13期号:6页码:957-968 |
发表状态 | 已发表 |
DOI | 10.1158/1541-7786.MCR-14-0580 |
摘要 | Oral squamous cell carcinoma (OSCC) is a prevalent form of cancer that develops from the epithelium of the oral cavity. OSCC is on the rise worldwide, and death rates associated with the disease are particularly high. Despite progress in understanding the mutational and expression landscape associated with OSCC, advances in deciphering these alterations for the development of therapeutic strategies have been limited. Further insight into the molecular cues that contribute to OSCC is therefore required. Here, we show that the transcriptional regulators YAP (YAP1) and TAZ (WWTR1), which are key effectors of the Hippo pathway, drive protumorigenic signals in OSCC. Regions of premalignant oral tissues exhibit aberrant nuclear YAP accumulation, suggesting that dysregulated YAP activity contributes to the onset of OSCC. Supporting this premise, we determined that nuclear YAP and TAZ activity drives OSCC cell proliferation, survival, and migration in vitro, and is required for OSCC tumor growth and metastasis in vivo. Global gene expression profiles associated with YAP and TAZ knockdown revealed changes in the control of gene expression implicated in protumorigenic signaling, including those required for cell cycle progression and survival. Notably, the transcriptional signature regulated by YAP and TAZ significantly correlates with gene expression changes occurring in human OSCCs identified by The Cancer Genome Atlas (TCGA), emphasizing a central role for YAP and TAZ in OSCC biology. (C) 2015 AACR. |
URL | 查看原文 |
收录类别 | SCI |
WOS研究方向 | Oncology ; Cell Biology |
WOS类目 | Oncology ; Cell Biology |
WOS记录号 | WOS:000358059200001 |
WOS关键词 | BREAST-CANCER CELLS ; YES-ASSOCIATED PROTEIN ; PATHWAY EFFECTOR YAP ; HIPPO PATHWAY ; NECK-CANCER ; GROWTH-CONTROL ; SELF-RENEWAL ; STEM-CELLS ; TAZ ; HEAD |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120944 |
专题 | 个人在本单位外知识产出 |
通讯作者 | Varelas, Xaralabos |
作者单位 | 1.Boston Univ, Sch Med, Dept Biochem, Boston, MA 02118 USA 2.Boston Univ, Sch Med, Sect Computat Biomed, Boston, MA 02118 USA 3.Boston Univ, Sch Dent Med, Dept Mol & Cell Biol, Boston, MA 02118 USA 4.Boston Univ, Sch Dent Med, Div Oral Pathol, Boston, MA 02118 USA 5.Boston Univ, Bioinformat Program, Boston, MA 02118 USA |
推荐引用方式 GB/T 7714 | Hiemer, Samantha E.,Zhang, Liye,Kartha, Vinay K.,et al. A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma[J]. MOLECULAR CANCER RESEARCH,2015,13(6):957-968. |
APA | Hiemer, Samantha E..,Zhang, Liye.,Kartha, Vinay K..,Packer, Trevor S..,Almershed, Munirah.,...&Varelas, Xaralabos.(2015).A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma.MOLECULAR CANCER RESEARCH,13(6),957-968. |
MLA | Hiemer, Samantha E.,et al."A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma".MOLECULAR CANCER RESEARCH 13.6(2015):957-968. |
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