Genome sequences of wild and domestic bactrian camels

doi:10.1038/ncomms2192

	Genome sequences of wild and domestic bactrian camels
	Jirimutu ; Wang, Zhen ; Ding, Guohui ; Chen, Gangliang ; Sun, Yamin ; Sun, Zhihong ; Zhang, Heping ; Wang, Lei ; Hasi, Surong ; Zhang, Yan ; Li, Jianmei ; Shi, Yixiang ; Xu, Ze ; He, Chuan ; Yu, Siriguleng ; Li, Shengdi ; Zhang, Wenbin ; Batmunkh, Mijiddorj ; Ts, Batsukh ; Narenbatu ; Unierhu ; Bat-Ireedui, Shirzana ; Gao, Hongwei ; Baysgalan, Banzragch ; Li, Qing ; Jia, Zhiling ; Turigenbayila ; Subudenggerile ; Narenmanduhu ; Wang, Zhaoxia ; Wang, Juan ; Pan, Lei ; Chen, Yongcan ; Ganerdene, Yaichil ; Dabxilt ; Erdemt ; Altansha ; Altansukh ; Liu, Tuya ; Cao, Minhui ; Aruuntsever ; Bayart ; Hosblig ; He, Fei ; Zha-ti, A.; Zheng, Guangyong ; Qiu, Feng ; Sun, Zikui ; Zhao, Lele ; Zhao, Wenjing ; Liu, Baohong ; Li, Chao ; Chen, Yunqin ; Tang, Xiaoyan ; Guo, Chunyan ; Liu, Wei ; Ming, Liang ; Temuulen ; Cui, Aiying ; Li, Yi ; Gao, Junhui ; Li, Jing ; Wurentaodi ; Niu, Shen ; Sun, Tao ; Zhai, Zhengxiao ; Zhang, Min ; Chen, Chen ; Baldan, Tunteg ; Bayaer, Tuman ; Li, Yixue; Meng, He
	2012
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	3
发表状态	已发表
DOI	10.1038/ncomms2192
摘要	Bactrian camels serve as an important means of transportation in the cold desert regions of China and Mongolia. Here we present a 2.01 Gb draft genome sequence from both a wild and a domestic bactrian camel. We estimate the camel genome to be 2.38 Gb, containing 20,821 protein-coding genes. Our phylogenomics analysis reveals that camels shared common ancestors with other even-toed ungulates about 55-60 million years ago. Rapidly evolving genes in the camel lineage are significantly enriched in metabolic pathways, and these changes may underlie the insulin resistance typically observed in these animals. We estimate the genome-wide heterozygosity rates in both wild and domestic camels to be 1.0 x 10(-3). However, genomic regions with significantly lower heterozygosity are found in the domestic camel, and olfactory receptors are enriched in these regions. Our comparative genomics analyses may also shed light on the genetic basis of the camel's remarkable salt tolerance and unusual immune system.
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语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000315992100037
WOS关键词	ALIGNMENT ; INSULIN ; RECONSTRUCTION ; PHYLOGENOMICS ; ANNOTATION ; GENETICS ; INSIGHTS ; PROGRAM ; GENES ; LIGHT
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120767
专题	个人在本单位外知识产出
通讯作者	Jirimutu; Li, Yixue; Meng, He
作者单位	1.Inner Mongolia Agr Univ, Coll Food Sci & Engn, Minist Educ, Key Lab Dairy Biotechnol & Engn, Hohhot 010018, Peoples R China 2.Shanghai Ctr Bioinformat Technol, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Syst Biol, Shanghai 200031, Peoples R China 4.Encode Genom Biotechnol Co Ltd, EG Informat Technol Enterprise EGI, Shanghai 200235, Peoples R China 5.Wangyuan Camel Milk Ltd Co, Bactrian Camel Acad Altai, Xinjiang 836500, Fuhai County, Peoples R China 6.Nankai Univ, TEDA, TEDA Sch Biol Sci & Biotechnolgy, Tianjin Key Lab Microbial Funct Genom, Tianjin 300457, Peoples R China 7.Inner Mongolia Agr Univ, Coll Vet Med, Minist Agr, Key Lab Clin Diag & Treatment Technol Anim Dis, Hohhot 010018, Peoples R China 8.Virginia Tech, Virginia Bioinformat Inst, Blacksburg, VA 24061 USA 9.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China 10.Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai Key Lab Vet Biotechnol, Shanghai 200240, Peoples R China 11.Bactrian Camel Inst Alsha, Bayanhot 750306, Inner Mongolia, Peoples R China 12.Minist Nat & Environm, Mongolian Wild Camel Protect Area, Ulaanbaatar 82050, Mongolia 13.Mongolian Univ Sci & Technol, Sukhbatar Dist 210646, Ulaanbaatar, Mongolia 14.Inner Mongolia Agr Univ, Coll Anim Sci, Hohhot 010018, Peoples R China 15.Zelem Ltd Co, Ulaanbaatar 210646, Mongolia 16.Shanghai Qual Safety Ctr Agr Prod, Shanghai 200335, Peoples R China 17.Olonlog Magazine, Khan Uul Dist 210431, Ulaanbaatar, Mongolia 18.Shanghai Personal Biotechnol Ltd Co, Shanghai 200336, Peoples R China 19.Atarchandagana Suu Ltd Co, Hentii Aimag 23140, Mongolia 20.Sunid Peoples Govt, Saihantal 011200, Inner Mongolia, Peoples R China 21.Anim Husb Workstn West Sunid, Saihantal 011200, Inner Mongolia, Peoples R China 22.Anim Husb Workstn Shiliingol Aimag, Shiliinhot City 026000, Inner Mongolia, Peoples R China 23.Anim Husb Inst Shiliingol Aimag, Shiliinhot City 026000, Inner Mongolia, Peoples R China 24.Vet Bur Eat Alsha, Bayanhot 750300, Inner Mongolia, Peoples R China 25.Anim Husb Workstn East Sunid, Mandalt 011300, Inner Mongolia, Peoples R China 26.Anim Husb Bur Otog, Erdos 016100, Inner Mongolia, Peoples R China 27.Anim Husb Bur North Urad, Bayannuur 015500, Inner Mongolia, Peoples R China 28.Xinjiang Acad Anim Sci, Inst Anim Sci, Urumqi 830000, Peoples R China 29.Res Inst Anim Husb, Khan Uul Dist 210153, Ulaanbaatar, Mongolia 30.Bur Agr & Anim Husb, Shiliingol Aimag 026200, Inner Mongolia, Peoples R China 31.Shanghai Jiao Tong Univ, Coll Life Sci & Biotechnol, Shanghai 200240, Peoples R China 32.Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China
推荐引用方式 GB/T 7714	Jirimutu,Wang, Zhen,Ding, Guohui,et al. Genome sequences of wild and domestic bactrian camels[J]. NATURE COMMUNICATIONS,2012,3.
APA	Jirimutu.,Wang, Zhen.,Ding, Guohui.,Chen, Gangliang.,Sun, Yamin.,...&Meng, He.(2012).Genome sequences of wild and domestic bactrian camels.NATURE COMMUNICATIONS,3.
MLA	Jirimutu,et al."Genome sequences of wild and domestic bactrian camels".NATURE COMMUNICATIONS 3(2012).