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Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification | |
2011 | |
发表期刊 | CELL |
ISSN | 0092-8674 |
卷号 | 146期号:6页码:115-127 |
发表状态 | 已发表 |
DOI | 10.1016/j.cell.2011.08.008 |
摘要 | We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), confirming that it represents an evolutionarily-conserved histone posttranslational modification. The unique structure and genomic localization of histone Kcr suggest that it is mechanistically and functionally different from histone lysine acetylation (Kac). Specifically, in both human somatic and mouse male germ cell genomes, histone Kcr marks either active promoters or potential enhancers. In male germinal cells immediately following meiosis, Kcr is enriched on sex chromosomes and specifically marks testis-specific genes, including a significant proportion of X-linked genes that escape sex chromosome inactivation in haploid cells. These results therefore dramatically extend the repertoire of histone PTM sites and designate Kcr as a specific mark of active sex chromosome-linked genes in postmeiotic male germ cells. |
URL | 查看原文 |
收录类别 | SCI |
WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
WOS记录号 | WOS:000295258100022 |
出版者 | CELL PRESS |
WOS关键词 | MASS-SPECTROMETRY ; POSTTRANSLATIONAL MODIFICATIONS ; CHROMATIN MODIFICATIONS ; HUMAN-CELLS ; CODE ; DISTINCT ; H3 ; PHOSPHORYLATION ; ACETYLATION ; METHYLATION |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119827 |
专题 | 个人在本单位外知识产出 |
通讯作者 | Zhao, Yingming |
作者单位 | 1.Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA 2.Univ Calif San Diego, Ludwig Inst Canc Res, Sch Med, La Jolla, CA 92093 USA 3.Univ Calif San Diego, Dept Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USA 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 5.Stanford Univ, Dept Chem & Syst Biol, Sch Med, Stanford, CA 94305 USA 6.INSERM, U823, F-38706 La Tronche, France 7.Univ Grenoble 1, F-38706 La Tronche, France 8.Fac Med, Inst Albert Bonniot, F-38706 La Tronche, France |
推荐引用方式 GB/T 7714 | Tan, Minjia,Luo, Hao,Lee, Sangkyu,et al. Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification[J]. CELL,2011,146(6):115-127. |
APA | Tan, Minjia.,Luo, Hao.,Lee, Sangkyu.,Jin, Fulai.,Yang, Jeong Soo.,...&Zhao, Yingming.(2011).Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification.CELL,146(6),115-127. |
MLA | Tan, Minjia,et al."Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification".CELL 146.6(2011):115-127. |
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