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Colocalization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 21, 页码: 9983-9989
Authors:  Zhou, Fang;  Ding, Kang;  Zhou, Yiqing;  Liu, Yang;  Liu, Xiaoyan;  Zhao, Fei;  Wu, Yiran;  Zhang, Xianjun;  Tan, Qiwen;  Xu, Fei;  Tan, Wenfu;  Xiao, Youli;  Zhao, Suwen;  Tao, Houchao
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Development of high potent and selective Bcl-2 inhibitors bearing the structural elements of natural product artemisinin 期刊论文
Authors:  Liu, Xiaohua;  Zhang, Yu;  Huang, Wenjing;  Luo, Jia;  Li, Yang;  Tan, Wenfu;  Zhang, Ao
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Design, synthesis and pharmacological evaluation of new acyl sulfonamides as potent and selective Bcl-2 inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 2, 页码: 443-454
Authors:  Liu, Xiaohua;  Zhang, Yu;  Huang, Wenjing;  Tan, Wenfu;  Zhang, Ao
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Discovery of Novel Macrocyclic Hedgehog Pathway Inhibitors Acting by Suppressing the Gli-Mediated Transcription 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 19, 页码: 8218-8245
Authors:  Liu, Gang;  Huang, Wenjing;  Wang, Juan;  Liu, Xiaohua;  Yang, Jun;  Zhang, Yu;  Geng, Yong;  Tan, Wenfu;  Zhang, Ao
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Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand 期刊论文
NATURE COMMUNICATIONS, 2017, 卷号: 8, 期号: 1
Authors:  Zhang, Xianjun;  Zhao, Fei;  Wu, Yiran;  Yang, Jun;  Han, Gye Won;  Zhao, Suwen;  Ishchenko, Andrii;  Ye, Lintao;  Lin, Xi;  Ding, Kang;  Dharmarajan, Venkatasubramanian;  Griffin, Patrick R.;  Gati, Cornelius;  Nelson, Garrett;  Hunter, Mark S.;  Hanson, Michael A.;  Cherezov, Vadim;  Stevens, Raymond C.;  Tan, Wenfu;  Tao, Houchao;  Xu, Fei
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Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 24, 页码: 11050-11068
Authors:  Liu, Gang;  Xue, Ding;  Yang, Jun;  Wan, Juan;  Liu, Xiaohua;  Huang, Wenjing;  Li, Jie;  Long, Ya-Qiu;  Tan, Wenfu;  Zhang, Ao
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