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Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19 期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2020
Authors:  Yu Bo;  Li Chenze;  Chen Peng;  Zhou Ning;  Wang Luyun;  Li Jia;  Jiang Hualiang;  Wang Dao-Wen
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Discovery of 8-Methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 3956-3975
Authors:  Li, Zizhou;  Xiao, Senhao;  Yang, Yaxi;  Chen, Chao;  Lu, Tian;  Chen, Zhifeng;  Jiang, Hualiang;  Chen, Shijie;  Luo, Cheng;  Zhou, Bing
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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
SCIENCE, 2020
Authors:  Wenhao Dai;  Bing Zhang;  Xia-Ming Jiang;  Haixia Su;  Jian Li;  Yao Zhao;  Xiong Xie;  Zhenming Jin;  Jingjing Peng;  Fengjiang Liu;  Chunpu Li;  You Li;  Fang Bai;  Haofeng Wang;  Xi Cheng;  Xiaobo Cen;  Shulei Hu;  Xiuna Yang;  Jiang Wang;  Xiang Liu;  Gengfu Xiao;  Hualiang Jiang;  Zihe Rao;  Lei-Ke Zhang;  Yechun Xu;  Haitao Yang;  Hong Liu
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Structure of Mpro from COVID-19 virus and discovery of its inhibitors 期刊论文
NATURE, 2020
Authors:  Zhenming Jin;  Xiaoyu Du;  Yechun Xu;  Yongqiang Deng;  Meiqin Liu;  Yao Zhao;  Bing Zhang;  Xiaofeng Li;  Leike Zhang;  Chao Peng;  Yinkai Duan;  Jing Yu;  Lin Wang;  Kailin Yang;  Fengjiang Liu;  Rendi Jiang;  Xinglou Yang;  Tian You;  Xiaoce Liu;  Xiuna Yang;  Fang Bai;  Hong Liu;  Xiang Liu;  Luke W. Guddat;  Wenqing Xu;  Gengfu Xiao;  Chengfeng Qin;  Zhengli Shi;  Hualiang Jiang;  Zihe Rao;  Haitao Yang
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KinomeX: a web application for predicting kinome-wide polypharmacology effect of small molecules 期刊论文
BIOINFORMATICS, 2019, 卷号: 35, 期号: 24, 页码: 5354-5356
Authors:  Li, Zhaojun;  Li, Xutong;  Liu, Xiaohong;  Fu, Zunyun;  Xiong, Zhaoping;  Wu, Xiaolong;  Tan, Xiaoqin;  Zhao, Jihui;  Zhong, Feisheng;  Wan, Xiaozhe;  Luo, Xiaomin;  Chen, Kaixian;  Jiang, Hualiang;  Zheng, Mingyue
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High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice 期刊论文
NATIONAL SCIENCE REVIEW, 2019, 卷号: 6, 期号: 6, 页码: 1223-1238
Authors:  Zhang, Xiaochuan;  Yin, Xianzhen;  Zhang, Jingjing;  Li, Anan;  Gong, Hui;  Luo, Qingming;  Zhang, Haiyan;  Gao, Zhaobing;  Jiang, Hualiang
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Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 16, 页码: 7473-7488
Authors:  Wang, Yulan;  Dai, Yang;  Wu, Xiaowei;  Li, Fei;  Liu, Bo;  Li, Chunpu;  Liu, Qiufeng;  Zhou, Yuanyang;  Wang, Bao;  Zhu, Mingrui;  Cui, Rongrong;  Tan, Xiaoqin;  Xiong, Zhaoping;  Liu, Jia;  Tan, Minjia;  Xu, Yechun;  Geng, Meiyu;  Jiang, Hualiang;  Liu, Hong;  Ai, Jing;  Zheng, Mingyue
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Improving the Virtual Screening Ability of Target-Specific Scoring Functions Using Deep Learning Methods 期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10
Authors:  Wang, Dingyan;  Cui, Chen;  Ding, Xiaoyu;  Xiong, Zhaoping;  Zheng, Mingyue;  Luo, Xiaomin;  Jiang, Hualiang;  Chen, Kaixian
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Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 86, 页码: 494-500
Authors:  Zhang, Dan;  Han, Jie;  Lu, Wenchao;  Lian, Fulin;  Wang, Jun;  Lu, Tian;  Tao, Hongru;  Xiao, Senhao;  Zhang, Fengcai;  Liu, Yu-Chih;  Liu, Rongfeng;  Zhang, Naixia;  Jiang, Hualiang;  Chen, Kaixian;  Zhao, Chunshen;  Luo, Cheng
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Discovery of trisubstituted nicotinonitrile derivatives as novel human GCN5 inhibitors through AlphaScreen-based high throughput screening 期刊论文
RSC ADVANCES, 2019, 卷号: 9, 期号: 9, 页码: 4917-4924
Authors:  Tao, Hongru;  Wang, Jun;  Lu, Wenchao;  Zhang, Rukang;  Xie, Yiqian;  Liu, Yu-Chih;  Liu, Rongfeng;  Yue, Liyan;  Chen, Kaixian;  Jiang, Hualiang;  Zhang, Yuanyuan;  Xu, Xiaohui;  Luo, Cheng
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