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Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding 期刊论文
SCIENCE, 2020, 卷号: 368, 期号: 6489, 页码: 428-+
Authors:  Yu, Jing;  Gimenez, Luis E.;  Hernandez, Ciria C.;  Wu, Yiran;  Wein, Ariel H.;  Han, Gye Won;  McClary, Kyle;  Mittal, Sanraj R.;  Burdsall, Kylie;  Stauch, Benjamin;  Wu, Lijie;  Stevens, Sophia N.;  Peisley, Alys;  Williams, Savannah Y.;  Chen, Valerie;  Millhauser, Glenn L.;  Zhao, Suwen;  Cone, Roger D.;  Stevens, Raymond C.
Favorite  |  View/Download:5/0  |  Submit date:2020/05/14
Structural basis of ligand recognition and self-activation of orphan GPR52 期刊论文
NATURE, 2020
Authors:  Lin, Xi;  Li, Mingyue;  Wang, Niandong;  Wu, Yiran;  Luo, Zhipu;  Guo, Shimeng;  Han, Gye-Won;  Li, Shaobai;  Yue, Yang;  Wei, Xiaohu;  Xie, Xin;  Chen, Yong;  Zhao, Suwen;  Wu, Jian;  Lei, Ming;  Xu, Fei
Favorite  |  View/Download:22/0  |  Submit date:2020/03/16
Molecular Mechanism for Ligand Recognition and Subtype Selectivity of alpha(2C) Adrenergic Receptor 期刊论文
CELL REPORTS, 2019, 卷号: 29, 期号: 10, 页码: 2936-+
Authors:  Chen, Xiaoyu;  Xu, Yueming;  Qu, Lu;  Wu, Lijie;  Han, Gye Won;  Guo, Yu;  Wu, Yiran;  Zhou, Qingtong;  Sun, Qianqian;  Chu, Cenfeng;  Yang, Jie;  Yang, Liu;  Wang, Quan;  Yuan, Shuguang;  Wang, Ling;  Hu, Tao;  Tao, Houchao;  Sun, Yaping;  Song, Yunpeng;  Hu, Liaoyuan;  Liu, Zhi-Jie;  Stevens, Raymond C.;  Zhao, Suwen;  Wu, Dong;  Zhong, Guisheng
View  |  Adobe PDF(2774Kb)  |  Favorite  |  View/Download:44/15  |  Submit date:2019/12/19
Structural Basis of the Diversity of Adrenergic Receptors 期刊论文
CELL REPORTS, 2019, 卷号: 29, 期号: 10, 页码: 2929-+
Authors:  Qu, Lu;  Zhou, Qingtong;  Xu, Yueming;  Guo, Yu;  Chen, Xiaoyu;  Yao, Deqiang;  Han, Gye Won;  Liu, Zhi-Jie;  Stevens, Raymond C.;  Zhong, Guisheng;  Wu, Dong;  Zhao, Suwen
View  |  Adobe PDF(2563Kb)  |  Favorite  |  View/Download:41/9  |  Submit date:2019/12/19
Elucidating the active delta-opioid receptor crystal structure with peptide and small-molecule agonists 期刊论文
SCIENCE ADVANCES, 2019, 卷号: 5, 期号: 11
Authors:  Claff, Tobias;  Yu, Jing;  Blais, Veronique;  Patel, Nilkanth;  Martin, Charlotte;  Wu, Lijie;  Han, Gye Won;  Holleran, Brian J.;  Van der Poorten, Olivier;  White, Kate L.;  Hanson, Michael A.;  Sarret, Philippe;  Gendron, Louis;  Cherezov, Vadim;  Katritch, Vsevolod;  Ballet, Steven;  Liu, Zhi-Jie;  Mueller, Christa E.;  Stevens, Raymond C.
View  |  Adobe PDF(1244Kb)  |  Favorite  |  View/Download:33/6  |  Submit date:2019/12/19
Crystal Structure of the Human Cannabinoid Receptor CB2 期刊论文
CELL, 2019, 卷号: 176, 期号: 3, 页码: 459-+
Authors:  Li, Xiaoting;  Hua, Tian;  Vemuri, Kiran;  Ho, Jo-Hao;  Wu, Yiran;  Wu, Lijie;  Popov, Petr;  Benchama, Othman;  Zvonok, Nikolai;  Locke, K'ara;  Qu, Lu;  Han, Gye Won;  Iyer, Malliga R.;  Cinar, Resat;  Coffey, Nathan J.;  Wang, Jingjing;  Wu, Meng;  Katritch, Vsevolod;  Zhao, Suwen;  Kunos, George;  Bohn, Laura M.;  Makriyannis, Alexandros;  Stevens, Raymond C.;  Liu, Zhi-Jie
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Crystal structure of misoprostol bound to the labor inducer prostaglandin E-2 receptor 期刊论文
NATURE CHEMICAL BIOLOGY, 2019, 卷号: 15, 期号: 1, 页码: 11-+
Authors:  Audet, Martin;  White, Kate L.;  Breton, Billy;  Zarzycka, Barbara;  Han, Gye Won;  Lu, Yan;  Gati, Cornelius;  Batyuk, Alexander;  Popov, Petr;  Velasquez, Jeffrey;  Manahan, David;  Hu, Hao;  Weierstall, Uwe;  Liu, Wei;  Shui, Wenqing;  Katritch, Vsevolod;  Cherezov, Vadim;  Hanson, Michael A.;  Stevens, Raymond C.
Adobe PDF(2500Kb)  |  Favorite  |  View/Download:82/0  |  Submit date:2019/01/05
Crystal structure of the Frizzled 4 receptor in a ligand-free state 期刊论文
NATURE, 2018, 卷号: 560, 期号: 7720, 页码: 666-+
Authors:  Yang, Shifan;  Wu, Yiran;  Xu, Ting-Hai;  de Waal, Parker W.;  He, Yuanzheng;  Pu, Mengchen;  Chen, Yuxiang;  DeBruine, Zachary J.;  Zhang, Bingjie;  Zaidi, Saheem A.;  Popov, Petr;  Guo, Yu;  Han, Gye Won;  Lu, Yang;  Suino-Powell, Kelly;  Dong, Shaowei;  Harikumar, Kaleeckal G.;  Miller, Laurence J.;  Katritch, Vsevolod;  Xu, H. Eric;  Shui, Wenqing;  Stevens, Raymond C.;  Melcher, Karsten;  Zhao, Suwen;  Xu, Fei
Adobe PDF(15788Kb)  |  Favorite  |  View/Download:134/2  |  Submit date:2018/09/18
Structural basis for signal recognition and transduction by platelet-activating-factor receptor 期刊论文
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2018, 卷号: 25, 期号: 6, 页码: 488-+
Authors:  Cao, Can;  Tan, Qiuxiang;  Xu, Chanjuan;  He, Lingli;  Yang, Linlin;  Zhou, Ye;  Zhou, Yiwei;  Qiao, Anna;  Lu, Minmin;  Yi, Cuiying;  Han, Gye Won;  Wang, Xianping;  Li, Xuemei;  Yang, Huaiyu;  Rao, Zihe;  Jiang, Hualiang;  Zhao, Yongfang;  Liu, Jianfeng;  Stevens, Raymond C.;  Zhao, Qiang;  Zhang, Xuejun C.;  Wu, Beili
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5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology 期刊论文
CELL, 2018, 卷号: 172, 期号: 4, 页码: 719-+
Authors:  Peng, Yao;  McCorvy, John D.;  Harpsoe, Kasper;  Lansu, Katherine;  Yuan, Shuguang;  Popov, Petr;  Qu, Lu;  Pu, Mengchen;  Che, Tao;  Nikolajsen, Louise F.;  Huang, Xi-Ping;  Wu, Yiran;  Shen, Ling;  Bjorn-Yoshimoto, Walden E.;  Ding, Kang;  Wacker, Daniel;  Han, Gye Won;  Cheng, Jianjun;  Katritch, Vsevolod;  Jensen, Anders A.;  Hanson, Michael A.;  Zhao, Suwen;  Gloriam, David E.;  Roth, Bryan L.;  Stevens, Raymond C.;  Liu, Zhi-Jie
Adobe PDF(6586Kb)  |  Favorite  |  View/Download:311/2  |  Submit date:2018/03/01