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Discovery of 8-Methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 3956-3975
Authors:  Li, Zizhou;  Xiao, Senhao;  Yang, Yaxi;  Chen, Chao;  Lu, Tian;  Chen, Zhifeng;  Jiang, Hualiang;  Chen, Shijie;  Luo, Cheng;  Zhou, Bing
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Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors 期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 80, 页码: 649-654
Authors:  Zhang, Li;  Chen, Yantao;  Liu, Na;  Li, Linjuan;  Xiao, Senhao;  Li, Xiaoliu;  Chen, Kaixian;  Luo, Cheng;  Chen, Shijie;  Chen, Hua
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Design, synthesis and biological evaluation of benzo[cd]indo1-2(1H)-ones derivatives as BRD4 inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 264-273
Authors:  Feng, Yuxin;  Xiao, Senhao;  Chen, Yantao;  Jiang, Hao;  Liu, Na;  Luo, Cheng;  Chen, Shijie;  Chen, Hua
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Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 1751-1758
Authors:  Song, Yakai;  Li, Linjuan;  Chen, Yantao;  Liu, Jingqiu;  Xiao, Senhao;  Lian, Fulin;  Zhang, Naixia;  Ding, Hong;  Zhang, Yuanyuan;  Chen, Kaixian;  Jiang, Hualiang;  Zhang, Chenhua;  Liu, Yu-Chih;  Chen, Shijie;  Luo, Cheng
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Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 卷号: 15, 期号: 44, 页码: 9352-9361
Authors:  Jiang, Hao;  Xing, Jing;  Wang, Chen;  Zhang, Hao;  Yue, Liyan;  Wan, Xiaozhe;  Chen, Wei;  Ding, Hong;  Xie, Yiqian;  Tao, Hongru;  Chen, Zhifeng;  Jiang, Hualiang;  Chen, Kaixian;  Chen, Shijie;  Zheng, Mingyue;  Zhang, Yuanyuan;  Luo, Cheng
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Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 21, 页码: 8888-8905
Authors:  Wang, Chen;  Jiang, Hao;  Jin, Jia;  Xie, Yiqian;  Chen, Zhifeng;  Zhang, Hao;  Lian, Fulin;  Liu, Yu-Chih;  Zhang, Chenhua;  Ding, Hong;  Chen, Shijie;  Zhang, Naixia;  Zhang, Yuanyuan;  Jiang, Hualiang;  Chen, Kaixian;  Ye, Fei;  Yao, Zhiyi;  Luo, Cheng
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Discovery of Novel Disruptor of Silencing Telomeric 1-Like (DOTI L) Inhibitors using a Target-Specific Scoring Function for the (S)-Adenosyl-L-methionine (SAM)-Dependent Methyltransferase Family 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 2026-2036
Authors:  Wang, Yulan;  Li, Linjuan;  Zhang, Bidong;  Xing, Jing;  Chen, Shijie;  Wan, Wei;  Song, Yakai;  Jiang, Hao;  Jiang, Hualiang;  Luo, Cheng;  Zheng, Mingyue
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Discovery of novel DNA methyltransferase 3A inhibitors via structure-based virtual screening and biological assays 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 2, 页码: 342-346
Authors:  Shao, Zhiyuan;  Xu, Pan;  Xu, Wen;  Li, Linjuan;  Liu, Shien;  Zhang, Rukang;  Liu, Yu-Chih;  Zhang, Chenhua;  Chen, Shijie;  Luo, Cheng
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Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays 期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2016, 卷号: 56, 期号: 3, 页码: 527-534
Authors:  Chen, Shijie;  Li, Linjuan;  Chen, Yantao;  Hu, Junchi;  Liu, Jingqiu;  Liu, Yu-Chih;  Liu, Rongfeng;  Zhang, Yuanyuan;  Meng, Fanwang;  Zhu, Kongkai;  Lu, Junyan;  Zheng, Mingyue;  Chen, Kaixian;  Zhang, Jin;  Jiang, Hualiang;  Yao, Zhiyi;  Luo, Cheng
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Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 58, 期号: 20, 页码: 8166-8181
Authors:  Meng, Fanwang;  Cheng, Sufang;  Ding, Hong;  Liu, Shien;  Liu, Yan;  Zhu, Kongkai;  Chen, Shijie;  Lu, Junyan;  Xie, Yiqian;  Li, Linjuan;  Liu, Rongfeng;  Shi, Zhe;  Zhou, Yu;  Liu, Yu-Chih;  Zheng, Mingyue;  Jiang, Hualiang;  Lu, Wencong;  Liu, Hong;  Luo, Cheng
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