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KinomeX: a web application for predicting kinome-wide polypharmacology effect of small molecules 期刊论文
BIOINFORMATICS, 2019, 卷号: 35, 期号: 24, 页码: 5354-5356
Authors:  Li, Zhaojun;  Li, Xutong;  Liu, Xiaohong;  Fu, Zunyun;  Xiong, Zhaoping;  Wu, Xiaolong;  Tan, Xiaoqin;  Zhao, Jihui;  Zhong, Feisheng;  Wan, Xiaozhe;  Luo, Xiaomin;  Chen, Kaixian;  Jiang, Hualiang;  Zheng, Mingyue
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Improving the Virtual Screening Ability of Target-Specific Scoring Functions Using Deep Learning Methods 期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10
Authors:  Wang, Dingyan;  Cui, Chen;  Ding, Xiaoyu;  Xiong, Zhaoping;  Zheng, Mingyue;  Luo, Xiaomin;  Jiang, Hualiang;  Chen, Kaixian
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Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 86, 页码: 494-500
Authors:  Zhang, Dan;  Han, Jie;  Lu, Wenchao;  Lian, Fulin;  Wang, Jun;  Lu, Tian;  Tao, Hongru;  Xiao, Senhao;  Zhang, Fengcai;  Liu, Yu-Chih;  Liu, Rongfeng;  Zhang, Naixia;  Jiang, Hualiang;  Chen, Kaixian;  Zhao, Chunshen;  Luo, Cheng
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The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 4, 页码: 638-645
Authors:  Ye, Xiaoqing;  Zhang, Rukang;  Lian, Fulin;  Zhang, Weiyao;  Lu, Wenchao;  Han, Jie;  Zhang, Naixia;  Jin, Jia;  Luo, Cheng;  Chen, Kaixian;  Ye, Fei;  Ding, Hong
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Discovery of trisubstituted nicotinonitrile derivatives as novel human GCN5 inhibitors through AlphaScreen-based high throughput screening 期刊论文
RSC ADVANCES, 2019, 卷号: 9, 期号: 9, 页码: 4917-4924
Authors:  Tao, Hongru;  Wang, Jun;  Lu, Wenchao;  Zhang, Rukang;  Xie, Yiqian;  Liu, Yu-Chih;  Liu, Rongfeng;  Yue, Liyan;  Chen, Kaixian;  Jiang, Hualiang;  Zhang, Yuanyuan;  Xu, Xiaohui;  Luo, Cheng
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Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 163, 页码: 281-294
Authors:  Xing, Jing;  Zhang, Rukang;  Jiang, Xiangrui;  Hu, Tianwen;  Wang, Xinjun;  Qiao, Gang;  Wang, Junjian;  Yang, Fengling;  Luo, Xiaomin;  Chen, Kaixian;  Shen, Jingshan;  Luo, Cheng;  Jiang, Hualiang;  Zheng, Mingyue
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Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 20, 页码: 5397-5407
Authors:  Lu, Wenchao;  Xiong, Huan;  Chen, Yu;  Wang, Chen;  Zhang, Hao;  Xu, Pan;  Han, Jie;  Xiao, Senhao;  Ding, Hong;  Chen, Zhifeng;  Lu, Tian;  Wang, Jun;  Zhang, Yuanyuan;  Yue, Liyan;  Liu, Yu-Chih;  Zhang, Chenhua;  Yang, Yaxi;  Jiang, Hualiang;  Chen, Kaixian;  Zhou, Bing;  Luo, Cheng
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Artificial intelligence in drug design 期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2018, 卷号: 61, 期号: 10, 页码: 1191-1204
Authors:  Zhong, Feisheng;  Xing, Jing;  Li, Xutong;  Liu, Xiaohong;  Fu, Zunyun;  Xiong, Zhaoping;  Lu, Dong;  Wu, Xiaolong;  Zhao, Jihui;  Tan, Xiaoqin;  Li, Fei;  Luo, Xiaomin;  Li, Zhaojun;  Chen, Kaixian;  Zheng, Mingyue;  Jiang, Hualiang
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Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors 期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 80, 页码: 649-654
Authors:  Zhang, Li;  Chen, Yantao;  Liu, Na;  Li, Linjuan;  Xiao, Senhao;  Li, Xiaoliu;  Chen, Kaixian;  Luo, Cheng;  Chen, Shijie;  Chen, Hua
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Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay 期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 9, 页码: 1544-1552
Authors:  Lu, Tian;  Hu, Jun-chi;  Lu, Wen-chao;  Han, Jie;  Ding, Hong;  Jiang, Hao;  Zhang, Yuan-yuan;  Yue, Li-yan;  Chen, Shi-jie;  Jiang, Hua-liang;  Chen, Kai-xian;  Chai, Hui-fang;  Luo, Cheng
Adobe PDF(3143Kb)  |  Favorite  |  View/Download:73/0  |  Submit date:2018/09/09