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Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 16, 页码: 7473-7488
Authors:  Wang, Yulan;  Dai, Yang;  Wu, Xiaowei;  Li, Fei;  Liu, Bo;  Li, Chunpu;  Liu, Qiufeng;  Zhou, Yuanyang;  Wang, Bao;  Zhu, Mingrui;  Cui, Rongrong;  Tan, Xiaoqin;  Xiong, Zhaoping;  Liu, Jia;  Tan, Minjia;  Xu, Yechun;  Geng, Meiyu;  Jiang, Hualiang;  Liu, Hong;  Ai, Jing;  Zheng, Mingyue
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Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis 期刊论文
NUCLEIC ACIDS RESEARCH, 2019, 卷号: 47, 期号: 12, 页码: 6538-6550
Authors:  Jia, Zhihui;  Yan, Liming;  Ren, Zhilin;  Wu, Lijie;  Wang, Jin;  Guo, Jing;  Zheng, Litao;  Ming, Zhenhua;  Zhang, Lianqi;  Lou, Zhiyong;  Rao, Zihe
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Artificial intelligence in drug design 期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2018, 卷号: 61, 期号: 10, 页码: 1191-1204
Authors:  Zhong, Feisheng;  Xing, Jing;  Li, Xutong;  Liu, Xiaohong;  Fu, Zunyun;  Xiong, Zhaoping;  Lu, Dong;  Wu, Xiaolong;  Zhao, Jihui;  Tan, Xiaoqin;  Li, Fei;  Luo, Xiaomin;  Li, Zhaojun;  Chen, Kaixian;  Zheng, Mingyue;  Jiang, Hualiang
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Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 卷号: 115, 期号: 32, 页码: E7469-E7477
Authors:  Qiang, Min;  Dong, Xue;  Zha, Zhao;  Zuo, Xiao-Kun;  Song, Xing-Lei;  Zhao, Lixia;  Yuan, Chao;  Huang, Chen;  Tao, Pingdong;  Hu, Qin;  Li, Wei-Guang;  Hu, Wanhui;  Li, Jie;  Nie, Yan;  Buratto, Damiano;  Zonta, Francesco;  Ma, Peixiang;  Yu, Zheng;  Liu, Lili;  Zhang, Yi;  Yang, Bei;  Xie, Jia;  Xu, Tian-Le;  Qu, Zhihu;  Yang, Guang;  Lerner, Richard A.
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Computational chemical biology and drug design: Facilitating protein structure, function, and modulation studies 期刊论文
MEDICINAL RESEARCH REVIEWS, 2018, 卷号: 38, 期号: 3, 页码: 914-950
Authors:  Zheng, Mingyue;  Zhao, Jihui;  Cui, Chen;  Fu, Zunyun;  Li, Xutong;  Liu, Xiaohong;  Ding, Xiaoyu;  Tan, Xiaoqin;  Li, Fei;  Luo, Xiaomin;  Chen, Kaixian;  Jiang, Hualiang
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An enzyme-mediated protein-fragment complementation assay for substrate screening of sortase A 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 卷号: 486, 期号: 2, 页码: 257-263
Authors:  Li, Ning;  Yu, Zheng;  Ji, Qun;  Sun, Jingying;  Liu, Xiao;  Du, Mingjuan;  Zhang, Wei
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Discovery of Novel Disruptor of Silencing Telomeric 1-Like (DOTI L) Inhibitors using a Target-Specific Scoring Function for the (S)-Adenosyl-L-methionine (SAM)-Dependent Methyltransferase Family 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 2026-2036
Authors:  Wang, Yulan;  Li, Linjuan;  Zhang, Bidong;  Xing, Jing;  Chen, Shijie;  Wan, Wei;  Song, Yakai;  Jiang, Hao;  Jiang, Hualiang;  Luo, Cheng;  Zheng, Mingyue
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Downregulated miR-29a/b/c during Contact Inhibition Stage Promote 3T3-L1 Adipogenesis by Targeting DNMT3A 期刊论文
PLOS ONE, 2017, 卷号: 12, 期号: 1
Authors:  Zhu, Yingjie;  Zheng, Guangyong;  Wang, Huichao;  Jia, Yudong;  Zhang, Ying;  Tang, Yanfeng;  Li, Wenlong;  Fan, Yanan;  Zhang, Xiaodong;  Liu, Youwen;  Liu, Sanhong
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Accessible Method for the Development of Novel Sterol Analogues with Dipeptide-like Side Chains That Act as Neuroinflammation Inhibitors 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2016, 卷号: 7, 期号: 3, 页码: 305-315
Authors:  Chen, Hongli;  Han, Chaojun;  Wu, Jing;  Liu, Xiaoyu;  Zhan, Yuexiong;  Chen, Jiakang;  Chen, Yanke;  Gu, Ruinan;  Zhang, Li;  Chen, Shuangshuang;  Jia, Jia;  Zhen, Xuechu;  Zheng, Long Tai;  Jiang, Biao
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Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays 期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2016, 卷号: 56, 期号: 3, 页码: 527-534
Authors:  Chen, Shijie;  Li, Linjuan;  Chen, Yantao;  Hu, Junchi;  Liu, Jingqiu;  Liu, Yu-Chih;  Liu, Rongfeng;  Zhang, Yuanyuan;  Meng, Fanwang;  Zhu, Kongkai;  Lu, Junyan;  Zheng, Mingyue;  Chen, Kaixian;  Zhang, Jin;  Jiang, Hualiang;  Yao, Zhiyi;  Luo, Cheng
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