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Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 190
Authors:  Chen, Yun;  Bai, Gang;  Ning, Yi;  Cai, Shi;  Zhang, Tao;  Song, Peiran;  Zhou, Jinpei;  Duan, Wenhu;  Ding, Jian;  Xie, Hua;  Zhang, Huibin
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Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 415-422
Authors:  Lai, Meng-zhen;  Song, Pei-ran;  Dou, Dou;  Diao, Yan-yan;  Tong, Lin-jiang;  Zhang, Tao;  Xie, Hua;  Li, Hong-lin;  Ding, Jian
Favorite  |  View/Download:15/0  |  Submit date:2020/03/16
Distributed Computation Offloading in Resource limited Fog Computing 会议论文
PROCEEDINGS OF THE 2019 IEEE 90TH VEHICULAR TECHNOLOGY CONFERENCE, Honolulu, Hawaii, USA, 22 Sept. - 25 Sept, 2019
Authors:  Hongbin Zhu;  Zhenghang Zhu;  Xiliang Luo;  Hua Qian
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Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 16, 页码: 7473-7488
Authors:  Wang, Yulan;  Dai, Yang;  Wu, Xiaowei;  Li, Fei;  Liu, Bo;  Li, Chunpu;  Liu, Qiufeng;  Zhou, Yuanyang;  Wang, Bao;  Zhu, Mingrui;  Cui, Rongrong;  Tan, Xiaoqin;  Xiong, Zhaoping;  Liu, Jia;  Tan, Minjia;  Xu, Yechun;  Geng, Meiyu;  Jiang, Hualiang;  Liu, Hong;  Ai, Jing;  Zheng, Mingyue
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Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395
Authors:  Diao, Yanyan;  Fang, Xiaoyu;  Song, Peiran;  Lai, Mengzhen;  Tong, Linjiang;  Hao, Yongjia;  Dou, Dou;  Liu, Yingqiang;  Ding, Jian;  Zhao, Zhenjiang;  Xie, Hua;  Li, Honglin
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Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction 期刊论文
ORGANIC LETTERS, 2019, 卷号: 21, 期号: 10, 页码: 3838-3841
Authors:  Qiu, Xing;  Sun, Ning;  Kong, Ying;  Li, Yan;  Yang, Xiaobao;  Jiang, Biao
Adobe PDF(1579Kb)  |  Favorite  |  View/Download:54/0  |  Submit date:2019/06/06
Optimization of novel benzofuro[3,2-b]pyridin-2(1H)-one derivatives as dual inhibitors of BTK and PI3K delta 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 304-316
Authors:  Liu, Linyi;  Li, Xinyu;  Cheng, Yu;  Wang, Lianjian;  Yang, Huizhu;  Li, Jiurong;  He, Siying;  Wu, Shuangjie;  Yin, Qianqian;  Xiang, Hua
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Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening 期刊论文
CHEMICAL COMMUNICATIONS, 2019, 卷号: 55, 期号: 6, 页码: 834-837
Authors:  Guo, Cuiping;  Chang, Yu;  Wang, Xin;  Zhang, Chengqian;  Hao, Piliang;  Ding, Ke;  Li, Zhengqiu
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Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627
Authors:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang;  Geng, Meiyu;  Ding, Jian;  Liu, Qingsong;  Sun, Liping;  Xie, Hua;  Zhang, Ao
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Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK) 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 151, 页码: 304-314
Authors:  Zhang, Chengwei;  Han, Xiao-Ran;  Yang, Xiaobao;  Jiang, Biao;  Liu, Jing;  Xiong, Yue;  Jin, Jian
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