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Structure-activity relationship analysis of meta-substituted N-cyclopropylmethyl-nornepenthones with mixed KOR/MOR activities
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 289
作者:
Tang, Siyuan
;
Hu, Shuyang
;
Feng, Lijing
;
Kong, Linghui
;
Gui, Jiangwen
Adobe PDF(2887Kb)
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收藏
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浏览/下载:43/1
|
提交时间:2025/03/25
N-Cyclopropylmethyl-nornepenthones
Structure-activity relationship
MOR antagonist
KOR agonist
Substance use disorder
Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods
期刊论文
MOLECULAR DIVERSITY, 2025
作者:
Wen, Yiming
;
Xu, Peijia
;
Chen, Yijie
;
Meng, Jingyi
;
Zheng, Mingyue
Adobe PDF(4175Kb)
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收藏
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浏览/下载:71/2
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提交时间:2025/03/03
p53 Y220C
Covalent stabilizer
Virtual screening
Molecular dynamics
DNA binding
Structure-activity relationship
Cancer therapy
Design, Synthesis and Biological Activity Study of γ-Aminobutyric Acid (GABA) Derivatives Containing Bridged Bicyclic Skeletons as BCAT1 Inhibitors
期刊论文
MOLECULES, 2025, 卷号: 30, 期号: 4
作者:
Luo, Wen
;
Pan, Zilu
;
Zhu, Xinyuan
;
Li, Yan
;
Li, Yong
Adobe PDF(2448Kb)
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收藏
|
浏览/下载:51/1
|
提交时间:2025/03/10
BCAT1 inhibitor
structure-activity relationship
cancer resistance
third-generation EGFR TKI
GABA
amino acid
bicyclo[3.2.1]octane
Synthesis and Biological Evaluation of β‐Lactam Derivatives Targeting Speckle-Type POZ Protein (SPOP)
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2024
作者:
Chenmao Zhou
;
Xinyue Hao
;
Zhengyang Chen
;
Runze Zhang
;
Qian Zhou
Adobe PDF(3478Kb)
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收藏
|
浏览/下载:138/0
|
提交时间:2024/11/27
Speckle-type POZ protein (SPOP)
SPOP inhibitors
Clear cell renal cell carcinoma (ccRCC)
Structure−activity relationship (SAR)
Structure-activity relationship study of a series of nucleoside derivatives bearing sulfonamide scaffold as potent and selective PRMT5 inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 130
作者:
Chen, Yuting
;
Shi, Qiongyu
;
Yang, Hong
;
Li, Jiayi
;
Zhou, Kaixin
Adobe PDF(8940Kb)
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收藏
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浏览/下载:389/0
|
提交时间:2022/12/02
Epigenetic
Nucleoside derivatives
PRMT5 inhibitor
Structure-activity Relationship, Prodrug
Direct synthesis of higher oxygenates via syngas over zinc oxide modified CoMn-based catalysts
期刊论文
APPLIED CATALYSIS A: GENERAL, 2022, 卷号: 648
作者:
Qi, Xingzhen
;
Lin, Tiejun
;
Gong, Kun
;
Wang, Xinxing
;
Lv, Dong
Adobe PDF(8561Kb)
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收藏
|
浏览/下载:266/0
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提交时间:2022/11/18
Catalyst activity
Catalyst selectivity
Cobalt compounds
II-VI semiconductors
Manganese compounds
Particle size
Synthesis gas
Active site
Co/co2C dual active site
Direct synthesis
High oxygenate synthesis
Structure performance
Structure-performance relationship
Syngas conversion
Zinc oxide modified
Zn promoters
]+ catalyst
Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110
作者:
Lin, Lin
;
Lin, Guangyao
;
Zhou, Qingtong
;
Bathgate, Ross A. D.
;
Gong, Grace Qun
Adobe PDF(4286Kb)
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收藏
|
浏览/下载:236/0
|
提交时间:2021/07/23
Synthesis
Structure-activity relationship
Relaxin family peptide receptor 4
Selective agonist
Molecular docking
Progress in Biological Activity and Synthesis of Nematode Hatching Pheromone Glycinoeclepin A
期刊论文
有机化学, 2021, 卷号: 41, 期号: 2, 页码: 553-566
作者:
Ma Ding
;
Ao Junli
;
Hu Naifeng
;
Liang Guangxin
Adobe PDF(869Kb)
|
收藏
|
浏览/下载:258/2
|
提交时间:2021/05/28
soybean cyst nematode
chemoreception
glycinoeclepin A
total synthesis
structure-activity relationship
Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 29, 期号: 115871, 页码: 1-12
作者:
Hao, Guiyun
;
Li, Hao
;
Yang, Fei
;
Dong, Duoling
;
Li, Zezhong
Adobe PDF(2529Kb)
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收藏
|
浏览/下载:348/0
|
提交时间:2021/04/01
S. pneumonia LeuRS (SpLeuRS)
Anti-pneumonia
Benzhydrol-Oxaborole
Structure-activity relationship
Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395
作者:
Diao, Yanyan
;
Fang, Xiaoyu
;
Song, Peiran
;
Lai, Mengzhen
;
Tong, Linjiang
Adobe PDF(2955Kb)
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收藏
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浏览/下载:485/9
|
提交时间:2019/08/20
Bruton's tyrosine kinase
B-cell malignancies
Potent inhibitors
Structure-activity relationship
Cellular activities
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