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Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models
期刊论文
NATURE BIOTECHNOLOGY, 2025
作者:
Feng, Xin
;
Jiang, Bo-Wen
;
Zhai, Si-Nan
;
Liu, Chu-Xiao
;
Wu, Hao
收藏
|
浏览/下载:26/0
|
提交时间:2025/04/11
Disease control
Neurodegenerative diseases
Neurons
Adeno-associated virus
Alzheimers disease
Disease phenotypes
Mice models
Neuroinflammation
Proinflammatory molecules
Protein kinase
RNA aptamer
Small-molecule inhibitors
Target proteins
Therapeutic application of circular RNA aptamers in a mouse model of psoriasis
期刊论文
NATURE BIOTECHNOLOGY, 2024, 卷号: 43, 期号: 2, 页码: 236-246
作者:
Guo, Si-Kun
;
Liu, Chu-Xiao
;
Xu, Yi-Feng
;
Wang, Xiao
;
Nan, Fang
Adobe PDF(16045Kb)
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收藏
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浏览/下载:362/0
|
提交时间:2024/05/11
Biosynthesis
Dermatology
Activated proteins
Down-stream
Immunogenicity
Mice models
Protein kinase
RNA aptamer
Synthesised
Therapeutic Application
Therapeutic modality
Therapeutic potentials
Ketogenic diet alleviates cognitive dysfunction and neuroinflammation in APP/PS1 mice via the Nrf2/HO-1 and NF-κB signaling pathways
期刊论文
NEURAL REGENERATION RESEARCH, 2023, 卷号: 18, 期号: 12
作者:
Jiang, Jingwen
;
Pan, Hong
;
Shen, Fanxia
;
Tan, Yuyan
;
Chen, Shengdi
Adobe PDF(3387Kb)
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收藏
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浏览/下载:425/1
|
提交时间:2023/10/23
Alzheimer's disease
APP/PS1 mice
cognitive impairment
ketogenic diet
neuroinflammation
nuclear factor-kappa B pathway
nuclear factor-erythroid 2-p45 derived factor 2/heme oxygenase-1
therapeutic benefits
MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice
期刊论文
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2023, 卷号: 43, 期号: 8
作者:
Gotru, Sanjeev Kiran
;
Mammadova-Bach, Elmina
;
Sogkas, Georgios
;
Schuhmann, Michael K.
;
Schmitt, Karen
Adobe PDF(7498Kb)
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收藏
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浏览/下载:532/176
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提交时间:2023/08/28
animals
blood platelets
humans
ischemic stroke
mice
thrombosis
TRPC6 cation channel
MousePath: Lightweight phone-to-web information sharing via mouse interface
期刊论文
PERVASIVE AND MOBILE COMPUTING, 2023, 卷号: 90
作者:
Yan, Yihui
;
Wang, Zhiwei
;
Huang, Qianyi
;
Yang, Zhice
Adobe PDF(1672Kb)
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收藏
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浏览/下载:352/2
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提交时间:2023/03/10
Bluetooth
Information analysis
Information dissemination
Mammals
Optical communication
Websites
Cross-device information sharing
Device information
Information sharing
Mouse interfaces
Optical mice
Smart phones
WEB application
Web applications
Web information
Web-page
Non-invasive visualization of amyloid-beta deposits in Alzheimer amyloidosis mice using magnetic resonance imaging and fluorescence molecular tomography
期刊论文
BIOMEDICAL OPTICS EXPRESS, 2022, 卷号: 13, 期号: 7, 页码: 3809-3822
作者:
Ren, Wuwei
;
Li, Linlin
;
Zhang, Jianru
;
Vaas, Markus
;
Klohs, Jan
Adobe PDF(16476Kb)
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收藏
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浏览/下载:268/0
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提交时间:2022/07/15
Brain
Data acquisition
Deposits
Disease control
Diseases
Fluorescence imaging
Glycoproteins
Image reconstruction
Image segmentation
Mammals
Physiological models
Tomography
Alzheimer
Amyloid betas
Amyloid-beta peptides
Anatomical information
Disease burdens
Fluorescence molecular tomography
Fluorescence reflectance imaging
Mice models
Non-invasive monitoring
Patient models
High-resolution relaxometry-based calibrated fMRI in murine brain: Metabolic differences between awake and anesthetized states
期刊论文
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2022
作者:
Xu, Mengyang
;
Bo, Binshi
;
Pei, Mengchao
;
Chen, Yuyan
Adobe PDF(1605Kb)
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收藏
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浏览/下载:843/1
|
提交时间:2021/12/13
Awake mice
anesthesia
dexmedetomidine
calibrated fMRI
CMRO2
TRUST
pCASL
Enabling Tangible Interaction on Non-touch Displays with Optical Mouse Sensor and Visible Light Communication
会议论文
CONFERENCE ON HUMAN FACTORS IN COMPUTING SYSTEMS - PROCEEDINGS, Virtual, Online, United states, April 30, 2022 - May 5, 2022
作者:
Yan, Yihui
;
Huang, Zezhe
;
Xudu, Feiyang
;
Yang, Zhice
Adobe PDF(4836Kb)
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收藏
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浏览/下载:315/3
|
提交时间:2022/06/10
Computer monitors
Cost effectiveness
Costs
Light
Mammals
Personal computers
User interfaces
High-precision
Input systems
Light signal
Low-costs
Optical mice
Optical mouse sensors
Real- time
Tabletop
Tangible
Tangible interaction
Intermittent protein restriction protects islet β cells and improves glucose homeostasis in diabetic mice
期刊论文
SCIENCE BULLETIN, 2022, 卷号: 67, 期号: 7
作者:
Wei, Siying
;
Li, Chenchen
;
Luo, Xuemei
;
Yang, Lanzexin
;
Yu, Long
Adobe PDF(7982Kb)
|
收藏
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浏览/下载:377/2
|
提交时间:2022/03/04
Cells
Cytology
Glucose
Mammals
Muscle
Nutrition
Diabetes intervention
Diabetic mice
Environmental factors
Genetic factors
Glucose homeostasis
Islet
Nutritional intervention
Protein restriction
ScRNA-seq
Streptozotocin
Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis
期刊论文
ADVANCED SCIENCE, 2022
作者:
Mao, Jianhua
;
Zhu, Kongkai
;
Long, Zhangbiao
;
Zhang, Huimin
;
Xiao, Bing
Adobe PDF(3696Kb)
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收藏
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浏览/下载:402/0
|
提交时间:2022/01/29
antithrombotic target
bleeding risk
E97A knock-in mice
small molecule
beta 3/Src interaction
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