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An Engineered Multivalent TMV Nanodisk Platform for Modulating Integrin Clustering and Cell Signaling
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 2025
作者:
He, Haobo
;
Zhou, Yihao
;
Du, Mingming
;
Zeng, Fanmeng
;
Cao, Yuheng
Adobe PDF(3913Kb)
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收藏
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浏览/下载:13/1
|
提交时间:2025/06/23
Integrin
Multivalence
Osteoarthritis receptor cluster
Tobacco mosaic virus
Integrin
Multivalence
Osteoarthritis receptor cluster
Tobacco mosaic virus
An Engineered Intravitreal Injection Retinal-Pigment-Epithelium-Tropic Adeno-Associated Virus Vector Expressing a Bispecific Antibody Binding VEGF-A and ANG-2 Rescues Neovascular Age-Related Macular Degeneration in Animal Models and Patients
期刊论文
RESEARCH, 2025, 卷号: 8
作者:
Cai, Yuan
;
Gu, Yonghao
;
Zhang, Jie
;
Zhu, Ying
;
Ma, Zhen
Adobe PDF(9093Kb)
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收藏
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浏览/下载:28/3
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提交时间:2025/06/09
Adeno-associated virus vectors
Age-related macular degeneration
Angiopoietin-2
Animal model
Antiangiogenesis
Antibody binding
Epithelium cells
Intravitreal injection
Retinal pigment epithelium
Vascular endothelial growth factor
Dynamic Cap-Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease
期刊论文
ADVANCED SCIENCE, 2025
作者:
Su, Haixia
;
Wu, Guoqing
;
Xiong, Muya
;
Wang, Yuhang
;
Cao, Junyuan
Adobe PDF(5337Kb)
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收藏
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浏览/下载:82/8
|
提交时间:2025/04/09
covalent inhibitors
I7L protease
monkeypox virus
protein structures
substrate proteolysis
Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models
期刊论文
NATURE BIOTECHNOLOGY, 2025
作者:
Feng, Xin
;
Jiang, Bo-Wen
;
Zhai, Si-Nan
;
Liu, Chu-Xiao
;
Wu, Hao
收藏
|
浏览/下载:75/0
|
提交时间:2025/04/11
Disease control
Neurodegenerative diseases
Neurons
Adeno-associated virus
Alzheimers disease
Disease phenotypes
Mice models
Neuroinflammation
Proinflammatory molecules
Protein kinase
RNA aptamer
Small-molecule inhibitors
Target proteins
Specific and efficient RNA A-to-I editing through cleavage of an ADAR inhibitor
期刊论文
NATURE BIOTECHNOLOGY, 2025
作者:
Guangye Li
;
Guo Chen
;
Guo-Hua Yuan
;
Jia Wei
;
Qingyang Ni
Adobe PDF(11217Kb)
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收藏
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浏览/下载:138/8
|
提交时间:2025/03/27
Adeno-associated virus
Adenosine deaminases
Ectopic expressions
Editing systems
Editing tools
High specificity
RNA editing
Target sites
Dengue Virus Replicative-Form dsRNA Is Recognized by Both RIG-I and MDA5 to Activate Innate Immunity
期刊论文
JOURNAL OF MEDICAL VIROLOGY, 2025, 卷号: 97, 期号: 2
作者:
Ye, Sichao
;
Liang, Yisha
;
Chang, Yu
;
Lai, Bailiang
;
Zhong, Jin
Adobe PDF(2081Kb)
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收藏
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浏览/下载:69/1
|
提交时间:2025/02/12
dengue virus
MDA5
pathogen-associated molecular patterns
replicative form
RIG-I
Excision of HIV-1 Provirus in Human Primary Cells with Nanocapsuled TALEN Proteins
期刊论文
ACS APPLIED BIO MATERIALS, 2025, 卷号: 8, 期号: 2, 页码: 1227-1239
作者:
Zhao, Ming
;
Wen, Jing
;
Chen, Irvin S. Y.
;
Liu, Jia
;
Lu, Yunfeng
Adobe PDF(6801Kb)
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收藏
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浏览/下载:79/3
|
提交时间:2025/02/28
T-cells
Transcription
Gene editing
Human immunodeficiency virus
Human immunodeficiency virus provirus elimination
Primary T cell
Protein delivery
Response elements
Trans-activation response
Trans-activation response element
Transcription activator-like effector nuclease nanoparticle
Transcription activators
A novel BSL-2 Lassa virus reverse genetics system modelling the complete viral life cycle
期刊论文
EMERGING MICROBES & INFECTIONS, 2024, 卷号: 13, 期号: 1
作者:
Hu, Xiaoyou
;
Bai, Xu
;
Tian, Fangling
;
Xing, Yifan
;
Shi, Yi
Adobe PDF(2015Kb)
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收藏
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浏览/下载:428/4
|
提交时间:2024/06/24
Antiviral
Lassa virus
minigenome
reverse genetics
ribavirin
A novel AAV Vector for gene therapy of RPE-related retinal degenerative diseases via intravitreal delivery
期刊论文
MOLECULAR NEURODEGENERATION, 2024, 卷号: 19, 期号: 1
作者:
Gong, Yajun
;
Huang, Xianyu
;
Tu, Tianxiang
;
Chu, Cenfeng
;
Xian, Chunrui
Adobe PDF(1205Kb)
|
收藏
|
浏览/下载:301/8
|
提交时间:2024/12/17
Retinal pigment epithelium (RPE)
Adeno-associated virus (AAV)
Gene therapy
Retinal degenerative diseases
Age-related macular degeneration (AMD)
Engineered IscB-uRNA system with improved base editing efficiency for disease correction via single AAV delivery in mice
期刊论文
CELL REPORTS, 2024, 卷号: 43, 期号: 11, 页码: 114973
作者:
guo,ruochen
;
sun,xiaozhi
;
wang,feizuo
;
han,dingyi
;
yang,qiaoxia
Adobe PDF(7204Kb)
|
收藏
|
浏览/下载:240/7
|
提交时间:2024/12/02
Adeno-associated virus
CP: Molecular biology
CRISPR ancestry nuclease
IscB-ωRNA system
RNA-guided nuclease
adenine base editing
cytosine base editing
gene editing therapy
protein engineering
transposon-encoded OMEGA system
tyrosinemia
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