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Design and synthesis of Thieno[3, 2-b]pyridinone derivatives exhibiting potent activities against
Mycobacterium tuberculosis
in vivo by targeting Enoyl-ACP reductase
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 279
作者:
Liang, Lihong
;
Liu, Zhiyong
;
Chen, Jie
;
Zha, Qin
;
Zhou, Yihuan
Adobe PDF(1929Kb)
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收藏
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浏览/下载:297/3
|
提交时间:2024/09/30
Thieno[3, 2-b]pyridinone
Anti-Tuberculosis activity
Scaffold hopping
InhA
InhA
Design, synthesis, and biological evaluation of 1,2,4-triazole derivatives as potent antitubercular agents
期刊论文
CHINESE CHEMICAL LETTERS, 2024, 卷号: 35, 期号: 3
作者:
Wen, Yu
;
Lun, Shichun
;
Jiao, Yuxue
;
Zhang, Wei
;
Hu, Tianyu
Adobe PDF(3352Kb)
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收藏
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浏览/下载:276/3
|
提交时间:2024/03/04
Tuberculosis
MDR and XDR-TB
MmpL3 inhibitor
4-Triazole
Structure -based drug design
Rapid and sensitive diagnosis of live Mycobacterium tuberculosis using clustered regularly interspaced short palindromic repeat-Cas13a point-of-care RNA testing
期刊论文
VIEW, 2024
作者:
Wang, Yu
;
Lin, Huihuang
;
Yang, Anqi
;
Huang, Jiaming
;
Ren, Weicong
Adobe PDF(2461Kb)
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收藏
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浏览/下载:285/3
|
提交时间:2024/05/24
Diagnosis
Molecular biology
RNA
Clustered regularly interspaced short palindromic repeat-cas13a
Lateral Flow
Limit of detection
Live mycobacteria tuberculosis
Mycobacterium tuberculosis
Palindromic
Point-of-care testing
Single stranded RNA
Single-stranded RNA
Molecular recognition of trehalose and trehalose analogues by
Mycobacterium tuberculosis
LpqY-SugABC
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 35
作者:
Liang, Jingxi
;
Liu, Fengjiang
;
Xu, Peng
;
Shangguan, Wei
;
Hu, Tianyu
收藏
|
浏览/下载:361/0
|
提交时间:2024/03/03
trehalose
trehalose analogue
LpqY-SugABC
ABC transporter
Mycobacterium tuberculosis
Molecular recognition of trehalose and trehalose analogues by Mycobacterium tuberculosis LpqY-SugABC
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 35
作者:
Liang, Jingxi
;
Liu, Fengjiang
;
Xu, Peng
;
Shangguan, Wei
;
Hu, Tianyu
Adobe PDF(3568Kb)
|
收藏
|
浏览/下载:279/0
|
提交时间:2024/03/03
trehalose
trehalose analogue
LpqY-SugABC
ABC transporter
Mycobacterium tuberculosis
PAM-Expanded Streptococcus thermophilus Cas9 C-to-T and C-to-G Base Editors for Programmable Base Editing in Mycobacteria
期刊论文
ENGINEERING, 2022
作者:
Zhang, Hongyuan
;
Zhang, Yifei
;
Wang, Wei-Xiao
;
Chen, Weizhong
;
Zhang, Xia
Adobe PDF(4002Kb)
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收藏
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浏览/下载:420/0
|
提交时间:2022/08/12
Aromatic compounds
Bacteria
C (programming language)
Genes
Genetic engineering
Proteins
Tubes (components)
Base editing
Cas9
Clustered regularly interspaced short palindromic repeat
Genetic manipulations
Genome editing
Mycobacterium smegmatis
Mycobacterium tuberculosis
Palindromic
Streptococcus thermophilus
Uracil-DNA glycosylase
A Recombinase Polymerase Amplification-Coupled Cas12a Mutant-Based Module for Efficient Detection of Streptomycin-Resistant Mutations in Mycobacterium tuberculosis
期刊论文
FRONTIERS IN MICROBIOLOGY, 2022, 卷号: 12
作者:
Liu, Peng
;
Wang, Xinjie
;
Liang, Juan
;
Dong, Qian
;
Zhang, Jinping
Adobe PDF(3414Kb)
|
收藏
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浏览/下载:679/226
|
提交时间:2022/02/11
streptomycin
drug resistance
tuberculosis
CRiSPR/Cas
recombinase polymerase amplification
Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB
期刊论文
PROTEIN & CELL, 2022
作者:
Sun, Shan
;
Gao, Yan
;
Yang, Xiaolin
;
Yang, Xiuna
;
Hu, Tianyu
Adobe PDF(5483Kb)
|
收藏
|
浏览/下载:668/4
|
提交时间:2022/11/14
ABC exporter-like importer
iron-loaded siderophore
IrtAB
Mycobacterium tuberculosis
ABC transporter
Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates
期刊论文
ELIFE, 2021, 卷号: 10
作者:
Zhou, Shan
;
Wang, Weiwei
;
Zhou, Xiaoting
;
Zhang, Yuying
;
Lai, Yuezheng
Adobe PDF(7497Kb)
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收藏
|
浏览/下载:858/2
|
提交时间:2021/12/27
Mycobacterium tuberculosis
cytochrome bcc complex
cryo-electron microscopy
Q203
TB47
Other
Structural Basis for the Inhibition of Mycobacterial MmpL3 by NITD-349 and SPIRO
期刊论文
JOURNAL OF MOLECULAR BIOLOGY, 2020, 卷号: 432, 期号: 16, 页码: 4426-4434
作者:
Yang, Xiaolin
;
Hu, Tianyu
;
Yang, Xiuna
;
Xu, Wenqing
;
Yang, Haitao
Adobe PDF(2457Kb)
|
收藏
|
浏览/下载:749/2
|
提交时间:2020/08/18
Mycobacterium tuberculosis
mycobacterial membrane protein Large
MmpL3
NITD-349
SPIRO
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