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Conformational restriction enables discovering a series of chroman derivatives as potent and selective Nav1.8 inhibitors with improved pharmacokinetic properties 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 293, 页码: 117697
作者:  Li, Na;  Wang, Linlin;  Hu, Xinyuan;  Xu, Haiyan;  Yang, Bowen
Adobe PDF(4737Kb)  |  收藏  |  浏览/下载：22/4  |  提交时间：2025/05/20
Structure-activity relationship analysis of meta-substituted N-cyclopropylmethyl-nornepenthones with mixed KOR/MOR activities 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 289
作者:  Tang, Siyuan;  Hu, Shuyang;  Feng, Lijing;  Kong, Linghui;  Gui, Jiangwen
Adobe PDF(2887Kb)  |  收藏  |  浏览/下载：56/1  |  提交时间：2025/03/25
Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods 期刊论文
MOLECULAR DIVERSITY, 2025
作者:  Wen, Yiming;  Xu, Peijia;  Chen, Yijie;  Meng, Jingyi;  Zheng, Mingyue
Adobe PDF(4175Kb)  |  收藏  |  浏览/下载：85/2  |  提交时间：2025/03/03
Design, Synthesis and Biological Activity Study of γ-Aminobutyric Acid (GABA) Derivatives Containing Bridged Bicyclic Skeletons as BCAT1 Inhibitors 期刊论文
MOLECULES, 2025, 卷号: 30, 期号: 4
作者:  Luo, Wen;  Pan, Zilu;  Zhu, Xinyuan;  Li, Yan;  Li, Yong
Adobe PDF(2448Kb)  |  收藏  |  浏览/下载：65/1  |  提交时间：2025/03/10
Synthesis and Biological Evaluation of β‐Lactam Derivatives Targeting Speckle-Type POZ Protein (SPOP) 期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 15, 期号: 2, 页码: 270-279
作者:  Chenmao Zhou;  Xinyue Hao;  Zhengyang Chen;  Runze Zhang;  Qian Zhou
Adobe PDF(3478Kb)  |  收藏  |  浏览/下载：154/0  |  提交时间：2024/11/27
Structure-activity relationship study of a series of nucleoside derivatives bearing sulfonamide scaffold as potent and selective PRMT5 inhibitors 期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 130
作者:  Chen, Yuting;  Shi, Qiongyu;  Yang, Hong;  Li, Jiayi;  Zhou, Kaixin
Adobe PDF(8940Kb)  |  收藏  |  浏览/下载：407/0  |  提交时间：2022/12/02
Direct synthesis of higher oxygenates via syngas over zinc oxide modified CoMn-based catalysts 期刊论文
APPLIED CATALYSIS A: GENERAL, 2022, 卷号: 648
作者:  Qi, Xingzhen;  Lin, Tiejun;  Gong, Kun;  Wang, Xinxing;  Lv, Dong
Adobe PDF(8561Kb)  |  收藏  |  浏览/下载：281/0  |  提交时间：2022/11/18
Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110
作者:  Lin, Lin;  Lin, Guangyao;  Zhou, Qingtong;  Bathgate, Ross A. D.;  Gong, Grace Qun
Adobe PDF(4286Kb)  |  收藏  |  浏览/下载：248/0  |  提交时间：2021/07/23
Progress in Biological Activity and Synthesis of Nematode Hatching Pheromone Glycinoeclepin A 期刊论文
有机化学, 2021, 卷号: 41, 期号: 2, 页码: 553-566
作者:  Ma Ding;  Ao Junli;  Hu Naifeng;  Liang Guangxin
Adobe PDF(869Kb)  |  收藏  |  浏览/下载：276/2  |  提交时间：2021/05/28
Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 29, 期号: 115871, 页码: 1-12
作者:  Hao, Guiyun;  Li, Hao;  Yang, Fei;  Dong, Duoling;  Li, Zezhong
Adobe PDF(2529Kb)  |  收藏  |  浏览/下载：368/0  |  提交时间：2021/04/01
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