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Generic protein-ligand interaction scoring by integrating physical prior knowledge and data augmentation modelling
期刊论文
NATURE MACHINE INTELLIGENCE, 2024, 卷号: 6, 期号: 6, 页码: 688-700
作者:
Cao, Duanhua
;
Chen, Geng
;
Jiang, Jiaxin
;
Yu, Jie
;
Zhang, Runze
Adobe PDF(3326Kb)
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收藏
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浏览/下载:184/0
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提交时间:2024/06/17
Graph neural networks
Lead compounds
Proteins
Data augmentation
Data-driven methods
Docking methods
Graph neural networks
Heterogeneous graph
Prior-knowledge
Protein-ligand interactions
Robust methods
Standing problems
Training data
The tumor suppressor NF2 modulates TEAD4 stability and activity in Hippo signaling via direct interaction
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2024, 卷号: 300, 期号: 5
作者:
Wu, Mengying
;
Hu, Liqiao
;
He, Lingli
;
Yuan, Liang
;
Yang, Lingling
Adobe PDF(2194Kb)
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浏览/下载:256/3
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提交时间:2024/05/11
Acylation
Cell signaling
Transcription
Transcription factors
Tumors
Coactivators
Crucial functions
Direct interactions
Direct links
Hippo pathway
Palmitoylation
Protein-protein interactions
Signalling pathways
TEAD4
Tumour suppressor
Comprehensive Profiling of Rapamycin Interacting Proteins with Multiple Mass Spectrometry-Based Omics Techniques
期刊论文
ANALYTICAL CHEMISTRY, 2023, 卷号: 95, 期号: 22, 页码: 8605-8612
作者:
Xu, Yao
;
Zheng, Mengmeng
;
Gong, Li
;
Liu, Guizhen
;
Qian, Shanshan
Adobe PDF(3754Kb)
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收藏
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浏览/下载:365/0
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提交时间:2023/06/26
Cell death
Drug interactions
Mass spectrometry
Proteins
'omics'
Adverse side effects
Binding proteins
Chemoproteomics
Drug-protein interactions
Functional interaction
Mechanism of action
Multiple mass
Physical interactions
Rapamycin
Peptide backbone-copper ring structure: A molecular insight into copper-induced amyloid toxicity (vol 31, 108702, 2022)
其他
CHINESE PHYSICS B, 2023-05-01, 卷号: 32, 期号: 6
作者:
Wang, Jing
;
Jiang, Xiankai
;
Su, Xiurong
;
Zhou, Xingfei
;
Wang, Yu
Adobe PDF(3737Kb)
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浏览/下载:374/1
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提交时间:2023/06/26
interactions between metal ion and protein
quantum chemistry calculation
protein aggregation
amyloid diseases
Genetic dissection of intercellular interactions in vivo by membrane-permeable protein
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA;, 2023, 卷号: 120, 期号: 1
作者:
Zhang, Shaohua
;
Zhang, Qianyu
;
Liu, Zixin
;
Liu, Kuo
;
He, Lingjuan
Adobe PDF(5921Kb)
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收藏
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浏览/下载:230/0
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提交时间:2023/03/24
genetic tool
intercellular interactions
liver zonation
membrane-permeable protein
niche
Utilization of macrocyclic peptides to target protein-protein interactions in cancer
期刊论文
FRONT. ONCOL., 2022, 卷号: 12
作者:
Yang, Jiawen
;
Zhu, Qiaoliang
;
Wu, Yifan
;
Qu, Xiaojuan
;
Liu, Haixia
Adobe PDF(1478Kb)
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浏览/下载:443/4
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提交时间:2022/11/17
protein-protein interactions, macrocyclic peptide, cancer, treatment, drug
Peptide backbone-copper ring structure: A molecular insight into copper-induced amyloid toxicity
期刊论文
CHINESE PHYSICS B, 2022, 卷号: 31, 期号: 10
作者:
Wang, Jing
;
Li, Hua
;
Jiang, Xiankai
;
Wu, Bin
;
Guo, Jun
Adobe PDF(3745Kb)
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收藏
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浏览/下载:356/0
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提交时间:2022/10/18
interactions between metal ion and protein
quantum chemistry calculation
protein aggregation
amyloid diseases
Profiling protein interactions by purification with capillary monolithic affinity column in combination with label-free quantitative proteomics
期刊论文
JOURNAL OF CHROMATOGRAPHY A, 2022, 卷号: 1676
作者:
Liu, Guizhen
;
Du, Yanan
;
Fu, Tao
;
Han, Ying
;
Pan, Lifeng
Adobe PDF(1922Kb)
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收藏
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浏览/下载:352/2
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提交时间:2022/07/15
Affinity chromatography
Chelation
Column chromatography
Fused silica
Molecular biology
Nickel compounds
Purification
Support vector machines
Affinity column
Affinity purification
Capillary monolithic affinity column
Chromatography columns
Immobilized metal affinity chromatography
Label free
Monolithics
Protein-protein interactions
Proteomics
Quantitative proteomics
RNA structure probing uncovers RNA structure-dependent biological functions
期刊论文
NATURE CHEMICAL BIOLOGY, 2021, 卷号: 17, 期号: 7, 页码: 755-766
作者:
Wang, Xi-Wen
;
Liu, Chu-Xiao
;
Chen, Ling-Ling
;
Zhang, Qiangfeng Cliff
Adobe PDF(1976Kb)
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收藏
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浏览/下载:316/0
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提交时间:2021/07/16
LONG NONCODING RNA
GENOME-WIDE MEASUREMENT
SECONDARY STRUCTURE
PROTEIN INTERACTIONS
GLOBAL ANALYSIS
X-CHROMOSOME
LIVING CELLS
XIST LNCRNA
REVEALS
DOMAINS
Profiling Drug-Protein Interactions by Micro Column Affinity Purification Combined with Label Free Quantification Proteomics(dagger)
期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2020
作者:
Gong, Li
;
Xu, Yao
;
Liu, Guizhen
;
Zheng, Mengmeng
;
Zhang, Xuepei
Adobe PDF(1760Kb)
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收藏
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浏览/下载:342/4
|
提交时间:2020/11/24
Drug
protein interactions
Label
free quantification
Proteomics
Affinity purification
FK506
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