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GW806742X can induce mouse MLKL activation by directly promoting MLKL kinase like domain dimerization
期刊论文
EXPERIMENTAL CELL RESEARCH, 2025, 卷号: 448, 期号: 1
作者:
Yuan, Feiyang
;
Zhang, Yu
;
Zhu, Xinxin
;
Hu, Hong
;
Nan, Ning
Adobe PDF(5511Kb)
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收藏
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浏览/下载:25/3
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提交时间:2025/05/06
GW806742X
Kinase-like domain
MLKL
Necroptosis
Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models
期刊论文
NATURE BIOTECHNOLOGY, 2025
作者:
Feng, Xin
;
Jiang, Bo-Wen
;
Zhai, Si-Nan
;
Liu, Chu-Xiao
;
Wu, Hao
收藏
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浏览/下载:52/0
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提交时间:2025/04/11
Disease control
Neurodegenerative diseases
Neurons
Adeno-associated virus
Alzheimers disease
Disease phenotypes
Mice models
Neuroinflammation
Proinflammatory molecules
Protein kinase
RNA aptamer
Small-molecule inhibitors
Target proteins
Therapeutic application of circular RNA aptamers in a mouse model of psoriasis
期刊论文
NATURE BIOTECHNOLOGY, 2025, 卷号: 43, 期号: 2
作者:
Guo, Si-Kun
;
Liu, Chu-Xiao
;
Xu, Yi-Feng
;
Wang, Xiao
;
Nan, Fang
Adobe PDF(16045Kb)
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浏览/下载:378/0
|
提交时间:2024/05/11
Biosynthesis
Dermatology
Activated proteins
Down-stream
Immunogenicity
Mice models
Protein kinase
RNA aptamer
Synthesised
Therapeutic Application
Therapeutic modality
Therapeutic potentials
Design and synthesis of pyridazin-4-one derivatives as necroptosis inhibitors
期刊论文
ARCHIV DER PHARMAZIE, 2025, 卷号: 358, 期号: 1
作者:
An, Yuxiang
;
Peng, Xia
;
Wang, Tianchen
;
Liu, Kaiyuan
;
Feng, Dazhi
Adobe PDF(3528Kb)
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浏览/下载:212/2
|
提交时间:2024/12/04
inhibitor
pharmacokinetic study
pyridazin-4-one
receptor-interacting protein kinase 1
selectivity
Integrative study of lung cancer adeno-to-squamous transition in EGFR TKI resistance identifies RAPGEF3 as a therapeutic target
期刊论文
NATIONAL SCIENCE REVIEW, 2024, 卷号: 11, 期号: 12
作者:
Wang, Hua
;
Tang, Shijie
;
Wu, Qibiao
;
He, Yayi
;
Zhu, Weikang
Adobe PDF(7984Kb)
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浏览/下载:196/3
|
提交时间:2024/12/30
EGFR-mutant lung cancer
adeno-to-squamous transition
tyrosine kinase inhibitor resistance
transcription factor network
RAPGEF3
Vascular endothelial growth factor receptor 2 as a potential host target for the inhibition of enterovirus replication
期刊论文
JOURNAL OF VIROLOGY, 2024
作者:
Zhao, Xiaoyu
;
Qiao, Rui
;
Hao, Meng
;
Xu, Longfa
;
Wang, Dong
Adobe PDF(3169Kb)
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收藏
|
浏览/下载:224/1
|
提交时间:2024/09/30
EV-A71
kinase inhibitors
VEGFR family
VEGFR2
host factor
KinomeMETA: meta-learning enhanced kinome-wide polypharmacology profiling
期刊论文
BRIEFINGS IN BIOINFORMATICS, 2024, 卷号: 25, 期号: 1
作者:
Qun Ren
;
Ning Qu
;
Jingjing Sun
;
Jingyi Zhou
;
Jin Liu
Adobe PDF(2916Kb)
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浏览/下载:176/10
|
提交时间:2024/11/27
deep learning
kinase inhibitors
kinome profiling
meta-learning
polypharmacology
Development of the nonreceptor tyrosine kinase FER-targeting PROTACs as a potential strategy for antagonizing ovarian cancer cell motility and invasiveness
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2023, 卷号: 299, 期号: 6
作者:
Zhang, Yanchun
;
Xiong, Xuexue
;
Sun, Renhong
;
Zhu, Xiaotong
;
Wang, Chen
Adobe PDF(2978Kb)
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收藏
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浏览/下载:417/8
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提交时间:2024/04/12
Amino acids
Cells
Diagnosis
Diseases
Enzymes
Tumors
Cell motility
Fps/fes related
Invasiveness
Ovarian cancer cells
Ovarian cancers
Ovarian carcinoma
Overexpressions
Protein degradation
Proteolysis-targeting chimera
Tyrosine kinase
Development of the non-receptor tyrosine kinase FER-targeting PROTACs as a potential strategy for antagonizing ovarian cancer cell motility and invasiveness
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2023
作者:
Yanchun Zhang
;
Xuexue Xiong
Adobe PDF(2707Kb)
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浏览/下载:346/4
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提交时间:2023/09/25
Protein degradation
PROTAC
Tyrosine kinase
FER
Ovarian cancer
An A-Kinase Anchoring Protein (ACBD3) Coordinates Traffic-Induced PKA Activation At The Golgi
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2023, 卷号: 299, 期号: 5
作者:
Adobe PDF(23708Kb)
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收藏
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浏览/下载:342/1
|
提交时间:2023/04/24
Enzymes
A-kinase-anchoring proteins
Acyl-CoA
Acyl-CoA-binding domain-containing 3
Binding domain
Endoplasmic reticulum
Golgi
KDEL receptor
Membrane trafficking
Protein kinase A
Regulatory subunits
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