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Expanding the utilization of binding pockets proves to be effective for noncovalent small molecule inhibitors against SARS-CoV-2 Mpro 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 289
作者:  Yang, Qi;  Huang, Xupeng;  Zhang, Hongbo;  Sun, Jing;  Tang, Jielin
Adobe PDF(5890Kb)  |  收藏  |  浏览/下载：87/9  |  提交时间：2025/04/07
Dynamic Cap-Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease 期刊论文
ADVANCED SCIENCE, 2025
作者:  Su, Haixia;  Wu, Guoqing;  Xiong, Muya;  Wang, Yuhang;  Cao, Junyuan
Adobe PDF(5337Kb)  |  收藏  |  浏览/下载：56/8  |  提交时间：2025/04/09
Exploiting synthetic lethality in PDAC with antibody drug conjugates and ATR inhibition 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 286
作者:  Li, Tao;  Yu, Xianqiang;  Wan, Xinyao;  Liu, Jing;  Zheng, Jie
Adobe PDF(10464Kb)  |  收藏  |  浏览/下载：146/17  |  提交时间：2025/02/17
Design, synthesis, and structure-activity relationship studies of triazolo-pyrimidine derivatives as WRN inhibitors for the treatment of MSI tumors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 282
作者:  Qibang Sui;  Yuanyang Zhou;  Manjia Li;  Dan Wang;  Rongrong Cui
Adobe PDF(7302Kb)  |  收藏  |  浏览/下载：270/15  |  提交时间：2024/11/27
Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models 期刊论文
NATURE BIOTECHNOLOGY, 2025
作者:  Feng, Xin;  Jiang, Bo-Wen;  Zhai, Si-Nan;  Liu, Chu-Xiao;  Wu, Hao
收藏  |  浏览/下载：47/0  |  提交时间：2025/04/11
New insights in the mechanism of the SARS-CoV-2 Mpro inhibition by benzisoselenazolones and diselenides 期刊论文
SCIENTIFIC REPORTS, 2024, 卷号: 14, 期号: 1
作者:  Sancineto, Luca;  Mangiavacchi, Francesca;  Dabrowska, Agnieszka;  Pacula-Miszewska, Agata J.;  Obieziurska-Fabisiak, Magdalena
Adobe PDF(1050Kb)  |  收藏  |  浏览/下载：473/48  |  提交时间：2024/05/15
Vascular endothelial growth factor receptor 2 as a potential host target for the inhibition of enterovirus replication 期刊论文
JOURNAL OF VIROLOGY, 2024
作者:  Zhao, Xiaoyu;  Qiao, Rui;  Hao, Meng;  Xu, Longfa;  Wang, Dong
Adobe PDF(3169Kb)  |  收藏  |  浏览/下载：217/1  |  提交时间：2024/09/30
Design, synthesis and biological evaluation of novel 3C-like protease inhibitors as lead compounds against SARS-CoV-2 期刊论文
FUTURE MEDICINAL CHEMISTRY, 2024
作者:  Yan, Yong;  Liu, Hanwen;  Wu, Di;  Gu, Zhihao;  Guo, Wenhao
Adobe PDF(3417Kb)  |  收藏  |  浏览/下载：206/0  |  提交时间：2024/05/14
Synthesis and Biological Evaluation of β‐Lactam Derivatives Targeting Speckle-Type POZ Protein (SPOP) 期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2024
作者:  Chenmao Zhou;  Xinyue Hao;  Zhengyang Chen;  Runze Zhang;  Qian Zhou
Adobe PDF(3478Kb)  |  收藏  |  浏览/下载：142/0  |  提交时间：2024/11/27
Cryoablation triggers type I interferon-dependent antitumor immunity and potentiates immunotherapy efficacy in lung cancer 期刊论文
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2024, 卷号: 12, 期号: 1
作者:  Gu, Chuanjia;  Wang, Xue;  Wang, Kaiyu;  Xie, Fangfang;  Chen, Luonan
Adobe PDF(5381Kb)  |  收藏  |  浏览/下载：366/63  |  提交时间：2024/03/04
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