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生命科学与技术学院 [15]

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	The structural basis of the G protein–coupled receptor and ion channel axis 期刊论文 CURRENT RESEARCH IN STRUCTURAL BIOLOGY, 2025 作者: Luo YL(罗煜林); Sun LP(孙立萍); Peng Y(彭瑶) Adobe PDF(2148Kb) \| 收藏 \| 浏览/下载：38/4 \| 提交时间：2025/04/04 Sensory neurons and GPCRs (G protein-coupled receptors) and ion channels and signal transduction and structural biology
	Structural Mass Spectrometry Captures Residue-Resolved Comprehensive Conformational Rearrangements of a G Protein-Coupled Receptor 期刊论文 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 卷号: 146, 期号: 29, 页码: 20045-20058 作者: Liu, Hongyue; Yan, Pengfei; Zhang, Zhaoyu; Han, Hongbo; Zhou, Qingtong Adobe PDF(7016Kb) \| 收藏 \| 浏览/下载：452/12 \| 提交时间：2024/08/09 Activation analysis Chemical activation Ligands Proteins 'current G protein G protein coupled receptors Limited proteolysis Multiple domains Receptor activation Receptor signaling Structural mass Structural snapshots Structural studies
	Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs 期刊论文 SCIENCE ADVANCES, 2024, 卷号: 10, 期号: 6 作者: Wang, James Jiqi; Jin, Sanshan; Zhang, Heng; Xu, Youwei; Hu, Wen Adobe PDF(2350Kb) \| 收藏 \| 浏览/下载：331/1 \| 提交时间：2024/03/08 Blood pressure Chemical activation Proteins Arterial hypertension Blood pressure regulation Coupled receptors Cryo-electron microscopy G protein Inflammatory response Ligand binding Prostacyclin receptors Receptor activation Therapeutic targets
	Structural basis for motilin and erythromycin recognition by motilin receptor 期刊论文 SCIENCE ADVANCES, 2023, 卷号: 9, 期号: 11 作者: You, Chongzhao; Zhang, Yumu; Xu, Youwei; Xu, Peiyu; Li, Zhen Adobe PDF(1651Kb) \| 收藏 \| 浏览/下载：361/2 \| 提交时间：2023/04/21 Hormones Peptides Class A G protein coupled receptors Gastrointestinal disorders Gastrointestinal motility Gastrointestinal tract Macrolide antibiotics Peptide hormones Potential drug targets Recognition mechanism Structural basis
	Structural insight into the constitutive activity of human orphan receptor GPR12 期刊论文 SCIENCE BULLETIN, 2023, 卷号: 68, 期号: 1, 页码: 95-104 作者: Li, Hao; Zhang, Jinyi; Yu, Yanan; Luo, Feng; Wu, Lijie Adobe PDF(3028Kb) \| 收藏 \| 浏览/下载：818/6 \| 提交时间：2023/03/10 Electron microscopes Ligands Proteins Signal transduction Adenosine monophosphate Constitutive activation Cryo-electron microscopy Cryo-electron microscopy structure Cyclic adenosine Cyclic adenosine monophosphate G protein coupled receptors G protein-coupled receptor 12 Orphan receptor Self-activation
	Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists 期刊论文 ACS CENTRAL SCIENCE, 2023, 卷号: 10, 期号: 5, 页码: 956-968 作者: Kosar, Miroslav; Sarott, Roman C.; Sykes, David A.; Viray, Alexander E. G.; Vitale, Rosa Maria Adobe PDF(8180Kb) \| 收藏 \| 浏览/下载：262/0 \| 提交时间：2024/04/12 Fluorescence imaging Ligands Molecular dynamics Proteins American Chemical Society Cannabinoid receptors Functional response G protein coupled receptors High affinity Inverse agonists Rational design Receptor ligands Structure-based Switch structure
	Adenosine A2AReceptor (A2AAR) Ligand Screening Using the 19F-NMR Probe FPPA 期刊论文 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 卷号: 145, 期号: 28, 页码: 15061-15064 作者: Zhang, Jinfeng; Feng, Dandan; Cheng, Jianjun; Wüthrich, Kurt Adobe PDF(1667Kb) \| 收藏 \| 浏览/下载：563/3 \| 提交时间：2023/07/28 Aromatic compounds Binding energy Lead compounds Ligands Molecules Organic pollutants Probes Adenosine receptor Binding affinities Drug discovery Experimental conditions G protein coupled receptors Ligand competitions Ligand screenings NMR probe Receptor ligands Small molecules
	Conformational Dynamics of the Activated GLP-1 Receptor-Gs Complex Revealed by Cross-Linking Mass Spectrometry and Integrative Structure Modeling 期刊论文 ACS CENTRAL SCIENCE, 2023, 卷号: 9, 期号: 5, 页码: 992-1007 作者: Yuan, Shijia; Xia, Lisha; Wang, Chenxi; Wu, Fan; Zhang, Bingjie Adobe PDF(3395Kb) \| 收藏 \| 浏览/下载：566/5 \| 提交时间：2023/05/19 Amino acids Dynamics Proteins Conformational dynamics Conformational ensemble Cross linking G protein G protein coupled receptors Integrative structure Receptor activation Receptor complex Receptor signaling Structure models
	Ugi Reaction Mediated Detergent Assembly for Membrane Protein Studies 期刊论文 CHEMISTRY-AN ASIAN JOURNAL, 2022 作者: Yang, Meifang; Luo, Weiling; Zhang, Wei; Wang, Huixia; Xue, Dongxiang Adobe PDF(4552Kb) \| 收藏 \| 浏览/下载：702/5 \| 提交时间：2022/06/24 Chemical reactions Proteins Soaps (detergents) 'current G protein coupled receptors Hydrophilic heads Hydrophobic tails Hydrophobic-hydrophilic Membrane proteins Modular assembly NMR studies Rapid expansion Ugi reaction
	Crystal structure of a constitutive active mutant of adenosine A(2A) receptor 期刊论文 IUCRJ, 2022, 卷号: 9 作者: Cui, Min; Zhou, Qingtong; Xu, Yueming; Weng, Yuan; Yao, Deqiang Adobe PDF(1345Kb) \| 收藏 \| 浏览/下载：2274/633 \| 提交时间：2022/05/31 constitutive active mutants adenosine A(2A) receptors crystal structures hydrophilic interaction networks molecular dynamics G-protein-coupled receptors agonists

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