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Design, Synthesis and Biological Activity Study of γ-Aminobutyric Acid (GABA) Derivatives Containing Bridged Bicyclic Skeletons as BCAT1 Inhibitors 期刊论文
MOLECULES, 2025, 卷号: 30, 期号: 4
作者:  Luo, Wen;  Pan, Zilu;  Zhu, Xinyuan;  Li, Yan;  Li, Yong
Adobe PDF(2448Kb)  |  收藏  |  浏览/下载：58/1  |  提交时间：2025/03/10
Amiloride Synergizes with EGFR PROTACs and Inhibitors to Overcome Therapeutic Resistance in NSCLC 期刊论文
BIOORGANIC CHEMISTRY, 2025
作者:  Xiaojuan Qu;  Hongyue Ou;  Yifan Wu;  Biao Jiang;  Xiaoling Song
Adobe PDF(3021Kb)  |  收藏  |  浏览/下载：32/7  |  提交时间：2025/05/27
Integrative study of lung cancer adeno-to-squamous transition in EGFR TKI resistance identifies RAPGEF3 as a therapeutic target 期刊论文
NATIONAL SCIENCE REVIEW, 2024, 卷号: 11, 期号: 12
作者:  Wang, Hua;  Tang, Shijie;  Wu, Qibiao;  He, Yayi;  Zhu, Weikang
Adobe PDF(7984Kb)  |  收藏  |  浏览/下载：192/3  |  提交时间：2024/12/30
Design, synthesis and biological evaluation of novel osimertinib derivatives as reversible EGFR kinase inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 238
作者:  Ding, Shi;  Gao, Ziye;  Hu, Ziqiang;  Qi, Rui;  Zheng, Xiangshan
Adobe PDF(8843Kb)  |  收藏  |  浏览/下载：368/0  |  提交时间：2022/08/15
Proteome-wide Identification of Off-Targets of a Potent EGFR(L858R/T790M) Mutant Inhibitor 期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2022
作者:  Lyu, Peng;  Jiang, Kaili;  Zhou, Yuee;  Hu, Jun;  Chang, Yu
Adobe PDF(3412Kb)  |  收藏  |  浏览/下载：294/0  |  提交时间：2022/02/11
Design, synthesis and biological evaluation of novel N-(3-amino-4-methoxyphenyl)acrylamide derivatives as selective EGFR(L858R/T790M) kinase inhibitors 期刊论文
BIOORGANIC CHEMISTRY, 2022, 卷号: 118
作者:  Ding, Shi;  Dong, Xiaoyong;  Gao, Ziye;  Zheng, Xiangshan;  Ji, Jingchao
Adobe PDF(8618Kb)  |  收藏  |  浏览/下载：225/0  |  提交时间：2022/08/15
Novel strategies to target EGFR proteins for degradation and their applications in non-small cell lung cancer 期刊论文
CHINESE JOURNAL OF NATURE, 2021, 卷号: 43, 期号: 6, 页码: 400-407
作者:  Xiaoling Song;  Xiaojuan Qu;  Siqi Qu;  Biao Jiang
Adobe PDF(1726Kb)  |  收藏  |  浏览/下载：650/9  |  提交时间：2021/12/30
靶向EGFR蛋白降解剂及其在非小细胞肺癌中的应用 期刊论文
自然杂志, 2021, 卷号: 43, 期号: 06, 页码: 400-407
作者:  宋肖玲;  屈小娟;  曲思琪;  姜标
Adobe PDF(1855Kb)  |  收藏  |  浏览/下载：450/9  |  提交时间：2022/12/14
Effective degradation of EGFR(L858R+T790M) mutant proteins by CRBN-based PROTACs through both proteosome and autophagy/lysosome degradation systems 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218
作者:  Qu, Xiaojuan;  Liu, Haixia;  Song, Xiaoling;  Sun, Ning;  Zhong, Hui
Adobe PDF(2916Kb)  |  收藏  |  浏览/下载：526/14  |  提交时间：2021/06/04
Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance 期刊论文
MOLECULAR CANCER, 2020, 卷号: 19, 期号: 1
作者:  Zhang, Tao;  Qu, Rong;  Chan, Shingpan;  Lai, Mengzhen;  Tong, Linjiang
Adobe PDF(2399Kb)  |  收藏  |  浏览/下载：742/248  |  提交时间：2020/06/17
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