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ShanghaiTech University Knowledge Management System
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A DXd/TLR7-Agonist Dual-Conjugate Anti-HER2 ADC Exerts Robust Antitumor Activity Through Tumor Cell Killing and Immune Activation
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2024, 卷号: 23, 期号: 11
作者:
Yue, Hangtian
;
Xu, Hui
;
Ma, Lanping
;
Li, Xiyuan
;
Yang, Biyu
Adobe PDF(4235Kb)
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收藏
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浏览/下载:224/2
|
提交时间:2024/09/21
Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2024, 卷号: 22, 期号: 6
作者:
Wang, Min
;
Li, Han
;
Hu, Bintao
;
Tang, Chunping
;
Xu, Hui
Adobe PDF(877Kb)
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收藏
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浏览/下载:250/2
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提交时间:2024/08/26
Vernonia sylvatica
Germacrane-type sesquiterpene lactone
Sylvaticalides A-H
Anti-inflammatory
NF-kappa B path- way
ISG pathway
Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING Pathway
期刊论文
RESEARCH, 2023, 卷号: 6
作者:
Jiang, Yu
;
Li, Xiyuan
;
Qian, Fenghui
;
Sun, Bingbing
;
Wang, Xiyuan
Adobe PDF(1153Kb)
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收藏
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浏览/下载:584/1
|
提交时间:2023/04/21
Antibiotics
Chemical activation
Escherichia coli
Mammals
Tumors
Adenosine monophosphate
Antitumor effect
Antitumour activity
Biological approach
Fine tuning
Immune activation
In-vitro
Innate immunes
Nissle 1917
Tumor therapy
Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth
期刊论文
CHEMICAL SCIENCE, 2023, 卷号: 14, 期号: 22, 页码: 5956-5964
作者:
Ding, Chunyong
;
Du, Mengyan
;
Xiong, Zhi
;
Wang, Xue
;
Li, Hongji
Adobe PDF(1667Kb)
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收藏
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浏览/下载:321/1
|
提交时间:2023/06/02
Carbonic anhydrase
Cell growth
Cell signaling
Chemical activation
Growth kinetics
Toxicity
Tumors
Adapter proteins
Blue light
Cell targeting
Clinical development
Critical challenges
Innate immunes
Synthesised
Tumour cells
Up-regulation
Zebrafish embryos
Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation
期刊论文
CELL DISCOVERY, 2022, 卷号: 8, 期号: 1
作者:
Xie, Zuoquan
;
Wang, Zhen
;
Fan, Fengying
;
Zhou, Jinpei
;
Hu, Zhaoxue
Adobe PDF(5990Kb)
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收藏
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浏览/下载:259/86
|
提交时间:2023/01/16
Structure-Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 241
作者:
Shen, Ancheng
;
Li, Xiyuan
;
Zhang, Yan
;
Ma, Jing
;
Xiao, Ruoxuan
Adobe PDF(6740Kb)
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收藏
|
浏览/下载:423/0
|
提交时间:2023/01/16
Innate immunity
STING Agonists
Structural modification
Immuno-oncology
Development of a novel lactate dehydrogenase A inhibitor with potent antitumor activity and immune activation
期刊论文
CANCER SCIENCE, 2022, 卷号: 113, 期号: 9, 页码: 2974-2985
作者:
Du, Mengyan
;
Yu, Ting
;
Zhan, Qinjinge
;
Li, Han
;
Zou, Yiping
Adobe PDF(10387Kb)
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收藏
|
浏览/下载:304/1
|
提交时间:2022/11/08
immunity
lactate
LDHA inhibitor
metabolic reprogramming
tumor microenvironment
Novel Sphingosine Kinase 1 Inhibitor Suppresses Growth of Solid Tumor and Inhibits the Lung Metastasis of Triple-Negative Breast Cancer
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 11
作者:
Zhang, Shurui
;
Chen, Xiaoxu
;
Wu, Chenglin
;
Xu, Hui
;
Xie, Xiong
Adobe PDF(11423Kb)
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收藏
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浏览/下载:519/0
|
提交时间:2022/07/01
Withaphysalins from Medicinal and Edible Physalis minima and Their Anti-inflammatory Activities
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2022
作者:
Hu, Bintao
;
Li, Han
;
Tang, Chunping
;
Ke, Chang-Qiang
;
Geng, Meiyu
Adobe PDF(2433Kb)
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收藏
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浏览/下载:238/0
|
提交时间:2022/05/20
Binding sites
Dichroism
Electrodeposition
Electrospray ionization
Mass spectrometry
Phosphatases
Single crystals
Spectroscopic analysis
X ray crystallography
14β-OH
Anti-inflammatories
Anti-inflammatory activity
Anti-inflammatory effects
Dual cells
Edible plants
Medicinal plants
NF-κb
Physalis minimum
Withaphysalin
Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215
作者:
Gao, Feng
;
Chen, Xiaoxu
;
Lu, Junyan
;
Hu, Shulei
;
Xu, Hui
Adobe PDF(2015Kb)
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收藏
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浏览/下载:538/1
|
提交时间:2021/04/30
Ceramide analogs
AKT inhibitor
MK2206
Colon cancer
Combination therapy
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