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High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases 期刊论文
NUCLEIC ACIDS RESEARCH, 2022, 卷号: 50, 期号: 2
作者:  Xiao, Senhao;  Guo, Siqi;  Han, Jie;  Sun, Yanli;  Wang, Mingchen
Adobe PDF(2812Kb)  |  收藏  |  浏览/下载：719/167  |  提交时间：2022/03/29
Discovery of a novel 53BP1 inhibitor through AlphaScreen-based high-throughput screening 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 34, 页码: #VALUE!
作者:  Sun, Yanli;  Lu, Haibo;  Fang, Xueyu;  Xiao, Senhao;  Yang, Feng
Adobe PDF(2299Kb)  |  收藏  |  浏览/下载：329/9  |  提交时间：2021/04/01
Targeting p300/CBP Attenuates Hepatocellular Carcinoma Progression through Epigenetic Regulation of Metabolism 期刊论文
CANCER RESEARCH, 2021, 卷号: 81, 期号: 4, 页码: 860-872
作者:  Cai, Ling-Yan;  Chen, Shi-Jie;  Xiao, Sen-Hao;  Sun, Qin-Juan;  Ding, Chen-Hong
Adobe PDF(2926Kb)  |  收藏  |  浏览/下载：391/0  |  提交时间：2021/04/01
Natural product 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021
作者:  Li, Wen;  Liao, Li-ping;  Song, Ning;  Liu, Yan-jun;  Ding, Yi-luan
Adobe PDF(3035Kb)  |  收藏  |  浏览/下载：377/1  |  提交时间：2021/05/14
Discovery of 8-Methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 3956-3975
作者:  Li, Zizhou;  Xiao, Senhao;  Yang, Yaxi;  Chen, Chao;  Lu, Tian
Adobe PDF(4699Kb)  |  收藏  |  浏览/下载：269/0  |  提交时间：2020/05/25
Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 86, 页码: 494-500
作者:  Zhang, Dan;  Han, Jie;  Lu, Wenchao;  Lian, Fulin;  Wang, Jun
Adobe PDF(1323Kb)  |  收藏  |  浏览/下载：515/7  |  提交时间：2019/05/05
Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 20, 页码: 5397-5407
作者:  Lu, Wenchao;  Xiong, Huan;  Chen, Yu;  Wang, Chen;  Zhang, Hao
Adobe PDF(5322Kb)  |  收藏  |  浏览/下载：507/0  |  提交时间：2018/12/10
Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors 期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 80, 页码: 649-654
作者:  Zhang, Li;  Chen, Yantao;  Liu, Na;  Li, Linjuan;  Xiao, Senhao
Adobe PDF(1138Kb)  |  收藏  |  浏览/下载：478/0  |  提交时间：2018/09/09
Design, synthesis and biological evaluation of benzo[cd]indo1-2(1H)-ones derivatives as BRD4 inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 264-273
作者:  Feng, Yuxin;  Xiao, Senhao;  Chen, Yantao;  Jiang, Hao;  Liu, Na
Adobe PDF(2785Kb)  |  收藏  |  浏览/下载：538/0  |  提交时间：2018/07/04
Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 1751-1758
作者:  Song, Yakai;  Li, Linjuan;  Chen, Yantao;  Liu, Jingqiu;  Xiao, Senhao
Adobe PDF(1688Kb)  |  收藏  |  浏览/下载：497/0  |  提交时间：2018/05/10
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