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Exploring Protein Conformational Changes Using a Large-Scale Biophysical Sampling Augmented Deep Learning Strategy 期刊论文
ADVANCED SCIENCE, 2024
作者:  Yao Hu;  Hao Yang;  Mingwei Li
Adobe PDF(6212Kb)  |  收藏  |  浏览/下载:433/9  |  提交时间:2024/09/11
DiffPROTACs is a deep learning-based generator for proteolysis targeting chimeras 期刊论文
BRIEFINGS IN BIOINFORMATICS, 2024, 卷号: 25, 期号: 5
作者:  Li, Fenglei;  Hu, Qiaoyu;  Zhou, Yongqi;  Yang, Hao;  Bai, Fang
Adobe PDF(1631Kb)  |  收藏  |  浏览/下载:507/76  |  提交时间:2024/08/26
Conformational Space Profiling Enhances Generic Molecular Representation for AI-Powered Ligand-Based Drug Discovery 期刊论文
ADVANCED SCIENCE, 2024, 卷号: 11, 期号: 40
作者:  Wang, Lin;  Wang, Shihang;  Yang, Hao;  Li, Shiwei;  Wang, Xinyu
Adobe PDF(4769Kb)  |  收藏  |  浏览/下载:436/20  |  提交时间:2024/09/08
Structural basis of antagonist selectivity in endothelin receptors 期刊论文
CELL DISCOVERY, 2024, 卷号: 10, 期号: 1
作者:  Hou, Junyi
Adobe PDF(4532Kb)  |  收藏  |  浏览/下载:424/15  |  提交时间:2024/08/14
Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase 期刊论文
COMMUNICATIONS BIOLOGY, 2024, 卷号: 7, 期号: 1
作者:  Qiao, Hang;  Wang, Zilu;  Yang, Hao;  Xia, Mingyu;  Yang, Guang
Adobe PDF(3569Kb)  |  收藏  |  浏览/下载:284/14  |  提交时间:2024/08/14
Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis 期刊论文
NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1
作者:  Wang, Dongdong;  Li, Yanxia;  Yang, Hao;  Shen, Xiaoqi;  Shi, Xiaolin
Adobe PDF(3220Kb)  |  收藏  |  浏览/下载:434/82  |  提交时间:2024/07/02
Engineering Miniature IscB Nickase for Robust Base Editing with Broad Targeting Range 期刊论文
NATURE CHEMICAL BIOLOGY, 2024
作者:  Han, Linxiao;  Hu, Yueer;  Mo, Qiqin;  Yang, Hao;  Gu, Feng
Adobe PDF(12540Kb)  |  收藏  |  浏览/下载:454/16  |  提交时间:2024/05/10
TEFDTA: a transformer encoder and fingerprint representation combined prediction method for bonded and non-bonded drug–target affinities 期刊论文
BIOINFORMATICS, 2023, 卷号: 40, 期号: 1, 页码: btad778
作者:  Zongquan Li;  Pengxuan Ren;  Hao Yang;  Fang Bai;  Jie Zheng
Adobe PDF(3196Kb)  |  收藏  |  浏览/下载:415/54  |  提交时间:2024/04/25
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