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Structural Optimization of Next-Generation TRK Inhibitors against Acquired Drug Resistance Mutations for the Treatment of Solid Tumors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2025
作者:  Xu, Zichao;  Liu, Yueling;  Wang, Peng;  Peng, Xia;  Cheng, Jiawei
Adobe PDF(5181Kb)  |  收藏  |  浏览/下载：34/1  |  提交时间：2025/05/20
Design and synthesis of pyridazin-4-one derivatives as necroptosis inhibitors 期刊论文
ARCHIV DER PHARMAZIE, 2025, 卷号: 358, 期号: 1
作者:  An, Yuxiang;  Peng, Xia;  Wang, Tianchen;  Liu, Kaiyuan;  Feng, Dazhi
Adobe PDF(3528Kb)  |  收藏  |  浏览/下载：213/2  |  提交时间：2024/12/04
A DXd/TLR7-Agonist Dual-Conjugate Anti-HER2 ADC Exerts Robust Antitumor Activity Through Tumor Cell Killing and Immune Activation 期刊论文
MOLECULAR CANCER THERAPEUTICS, 2024, 卷号: 23, 期号: 11, 页码: 1639-1651
作者:  Yue, Hangtian;  Xu, Hui;  Ma, Lanping;  Li, Xiyuan;  Yang, Biyu
Adobe PDF(4235Kb)  |  收藏  |  浏览/下载：251/2  |  提交时间：2024/09/21
13,14-seco seco withaphysalins from Physalis minima and their inhibitory effects on NLRP3 inflammasome activation 期刊论文
BIOORGANIC CHEMISTRY, 2024, 卷号: 151
作者:  Hu, Bintao;  Peng, Xia;  Tang, Chunping;  Geng, Meiyu;  Yao, Sheng
Adobe PDF(1660Kb)  |  收藏  |  浏览/下载：308/2  |  提交时间：2024/08/14
Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation 期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 卷号: 9, 期号: 1
作者:  Zhang, Tao;  Pan, Zilu;  Gao, Jing;  Wu, Qingqing;  Bai, Gang
Adobe PDF(6886Kb)  |  收藏  |  浏览/下载：193/4  |  提交时间：2024/09/08
Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance (vol 19, 90, 2020) 其他
MOLECULAR CANCER, 2023-08-19, 卷号: 22, 期号: 1
作者:  Zhang, Tao;  Qu, Rong;  Chan, Shingpan;  Lai, Mengzhen;  Tong, Linjiang
Adobe PDF(880Kb)  |  收藏  |  浏览/下载：409/77  |  提交时间：2023/09/08
Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth 期刊论文
CHEMICAL SCIENCE, 2023, 卷号: 14, 期号: 22, 页码: 5956-5964
作者:  Ding, Chunyong;  Du, Mengyan;  Xiong, Zhi;  Wang, Xue;  Li, Hongji
Adobe PDF(1667Kb)  |  收藏  |  浏览/下载：339/1  |  提交时间：2023/06/02
Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING Pathway 期刊论文
RESEARCH, 2023, 卷号: 6
作者:  Jiang, Yu;  Li, Xiyuan;  Qian, Fenghui;  Sun, Bingbing;  Wang, Xiyuan
Adobe PDF(1153Kb)  |  收藏  |  浏览/下载：662/1  |  提交时间：2023/04/21
Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation 期刊论文
CELL DISCOVERY, 2022, 卷号: 8, 期号: 1
作者:  Xie, Zuoquan;  Wang, Zhen;  Fan, Fengying;  Zhou, Jinpei;  Hu, Zhaoxue
Adobe PDF(5990Kb)  |  收藏  |  浏览/下载：267/91  |  提交时间：2023/01/16
Structure-Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 241
作者:  Shen, Ancheng;  Li, Xiyuan;  Zhang, Yan;  Ma, Jing;  Xiao, Ruoxuan
Adobe PDF(6740Kb)  |  收藏  |  浏览/下载：437/0  |  提交时间：2023/01/16
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