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Design, synthesis, and structure-activity relationship studies of triazolo-pyrimidine derivatives as WRN inhibitors for the treatment of MSI tumors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 282
作者:  Qibang Sui;  Yuanyang Zhou;  Manjia Li;  Dan Wang;  Rongrong Cui
Adobe PDF(7302Kb)  |  收藏  |  浏览/下载：249/14  |  提交时间：2024/11/27
Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRASG12D 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2
作者:  Zhou, Chuan;  Fan, Zisheng;  Gu, Yuejiao;  Ge, Zhiming;  Tao, Zhaofan
Adobe PDF(8664Kb)  |  收藏  |  浏览/下载：310/14  |  提交时间：2024/03/04
Sequence-based drug design as a concept in computational drug design 期刊论文
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1
作者:  Chen, Lifan;  Fan, Zisheng;  Chang, Jie;  Yang, Ruirui;  Hou, Hui
Adobe PDF(3338Kb)  |  收藏  |  浏览/下载：550/184  |  提交时间：2023/08/21
Transfer Learning Enhanced Graph Neural Network for Aldehyde Oxidase Metabolism Prediction and Its Experimental Application 预印本
2023
作者:  Xiong, Jiacheng;  Cui, Rongrong;  Li, Zhaojun;  Zhang, Wei;  Zhang, Runze
Adobe PDF(947Kb)  |  收藏  |  浏览/下载：179/0  |  提交时间：2024/01/09
Discovery of Pyrazolo[3,4-d]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 1
作者:  Tan, Xiaoqin;  Li, Chunpu;  Yang, Ruirui;  Zhao, Sen;  Li, Fei
Adobe PDF(12500Kb)  |  收藏  |  浏览/下载：308/0  |  提交时间：2022/03/23
Active Learning for Drug Design: A Case Study on the Plasma Exposure of Orally Administered Drugs 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 22
作者:  Ding, Xiaoyu;  Cui, Rongrong;  Yu, Jie;  Liu, Tiantian;  Zhu, Tingfei
Adobe PDF(4647Kb)  |  收藏  |  浏览/下载：379/0  |  提交时间：2022/02/28
Revisiting Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: An Improved Computational Model 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 12, 页码: 6523-6537
作者:  Zhao, Jihui;  Cui, Rongrong;  Wang, Lihao;  Chen, Yingjia;  Fu, Zunyun
Adobe PDF(5726Kb)  |  收藏  |  浏览/下载：320/0  |  提交时间：2020/07/20
Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 16, 页码: 7473-7488
作者:  Wang, Yulan;  Dai, Yang;  Wu, Xiaowei;  Li, Fei;  Liu, Bo
Adobe PDF(3590Kb)  |  收藏  |  浏览/下载：635/14  |  提交时间：2019/09/10
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