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靶蛋白降解化合物、其抗肿瘤用途、其中间体及其用途 专利
申请号:US18923448，申请日期: 2025-02-27，类型:发明申请，状态:实质审查
发明人:  Xiaobao Yang;  Biao Jiang;  Renhong Sun;  Chaowei Ren;  Ning Sun
Adobe PDF(15448Kb)  |  收藏  |  浏览/下载：93/0  |  提交时间：2025/02/28
Targeted Degradation of SOS1 Exhibits Potent Anticancer Activity and Overcomes Resistance in KRAS-Mutant Tumors and BCR-ABL-Positive Leukemia 期刊论文
CANCER RESEARCH, 2025, 卷号: 85, 期号: 1
作者:  Luo, Ziwei;  Lin, Chencen;  Yu, Chuwei;  Yuan, Changxian;  Wu, Wenyong
Adobe PDF(22554Kb)  |  收藏  |  浏览/下载：177/4  |  提交时间：2025/01/13
Minimizing DNA trapping while maintaining activity inhibition via selective PARP1 degrader 期刊论文
CELL DEATH & DISEASE, 2024, 卷号: 15, 期号: 12
作者:  Chen, Li;  Zou, Yahui;  Sun, Renhong;  Huang, Mei;  Zhu, Xiaotong
Adobe PDF(6267Kb)  |  收藏  |  浏览/下载：305/8  |  提交时间：2024/12/03
Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice 期刊论文
NATURE, 2024, 卷号: 629, 期号: 8014
作者:  Wang, Gang;  Chen, Xi;  Yu, Chengzhi;  Shi, Xiaobao;  Lan, Wenxian
Adobe PDF(78518Kb)  |  收藏  |  浏览/下载：212/1  |  提交时间：2024/07/22
Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase 期刊论文
FEBS LETTERS, 2024
作者:  Chen, Xiaobao;  Guo, Yu;  Shi, Jiawen;  Wang, Yilun;  Guo, Xinyi
Adobe PDF(3053Kb)  |  收藏  |  浏览/下载：399/3  |  提交时间：2024/03/04
Development of the nonreceptor tyrosine kinase FER-targeting PROTACs as a potential strategy for antagonizing ovarian cancer cell motility and invasiveness 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2023, 卷号: 299, 期号: 6
作者:  Zhang, Yanchun;  Xiong, Xuexue;  Sun, Renhong;  Zhu, Xiaotong;  Wang, Chen
Adobe PDF(2978Kb)  |  收藏  |  浏览/下载：397/7  |  提交时间：2024/04/12
Development of the non-receptor tyrosine kinase FER-targeting PROTACs as a potential strategy for antagonizing ovarian cancer cell motility and invasiveness 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2023
作者:  Yanchun Zhang;  Xuexue Xiong;  Renhong Sun;  Xiaotong Zhu;  Chen Wang
Adobe PDF(2707Kb)  |  收藏  |  浏览/下载：334/4  |  提交时间：2023/09/25
Discovery of novel BCR-ABL PROTACs based on the cereblon E3 ligase design, synthesis, and biological evaluation (vol 223, 113645, 2021) 其他
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023-04-05, 卷号: 252
作者:  Liu, Haixia;  Ding, Xinyu;  Liu, Linyi;  Mi, Qianglong;  Zhao, Quanju
Adobe PDF(3283Kb)  |  收藏  |  浏览/下载：409/5  |  提交时间：2023/05/15
Discovery and characterization of novel potent BCR-ABL degraders by conjugating allosteric inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 244
作者:  Liu, Haixia;  Mi, Qianglong;  Ding, Xinyu;  Lin, Chencen;  Liu, Linyi
Adobe PDF(6603Kb)  |  收藏  |  浏览/下载：770/11  |  提交时间：2022/11/08
ALK proteolytic agents and their use in cancer therapy 专利
申请号:JP2022134524，申请日期: 2022-11-22，类型:发明申请，状态:授权
发明人:  Yang XB(楊小宝);  Jiang B(姜 標);  Song XL(宋肖玲);  Lin HF(林海帆);  Sun N(孫寧)
Unknown(104169Kb)  |  收藏  |  浏览/下载：355/2  |  提交时间：2022/11/23
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