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Conformational restriction enables discovering a series of chroman derivatives as potent and selective Nav1.8 inhibitors with improved pharmacokinetic properties
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 293, 页码: 117697
作者:
Li, Na
;
Wang, Linlin
;
Hu, Xinyuan
;
Xu, Haiyan
;
Yang, Bowen
Adobe PDF(4737Kb)
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浏览/下载:37/5
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提交时间:2025/05/20
Voltage-gated sodium channel 1.8
Conformational restriction
Pharmacokinetic
Structure-activity relationship
Analgesic
Glycan Sequencing Based on Glycosidase-Assisted Nanopore Sensing
期刊论文
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2025, 卷号: 147, 期号: 2, 页码: 1721-1731
作者:
Adobe PDF(6300Kb)
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浏览/下载:123/2
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提交时间:2025/01/13
High performance liquid chromatography
Hydrolysis
Micropores
'current
Building blockes
Glycan analysis
Glycan chains
Glycans
Glycosidases
Glycosidic linkages
Hydrolysis products
Machine-learning
Proof of concept
Discovery of Selective GluN1/GluN3A NMDA Receptor Inhibitors Using Integrated AI and Physics-Based Approaches
期刊论文
ACTA PHARMACOLOGICA SINICA, 2025
作者:
Shiwei Li
;
Yue Zeng
;
Sanan Wu
;
Xinyue Ma
;
Chao Xu
收藏
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浏览/下载:107/0
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提交时间:2025/03/12
Nanopore-based glycan sequencing: state of the art and future prospects
期刊论文
CHEMICAL SCIENCE, 2024, 卷号: 15, 期号: 17, 页码: 6229-6243
作者:
Yao, Guangda
Adobe PDF(1047Kb)
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浏览/下载:313/8
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提交时间:2024/05/14
Electric current measurement
Hydrolysis
Nanopores
Nucleic acids
Polysaccharides
Signal processing
Biomacromolecule
Current detection
Future prospects
Glycans
Life-sciences
Pathological functions
Physiological functions
State of the art
Structural complexity detections
Technical route
Direct Identification of Complex Glycans via a Highly Sensitive Engineered Nanopore
期刊论文
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 卷号: 146, 期号: 19, 页码: 13356-13366
作者:
Yao, Guangda
;
Tian, Yinping
;
Ke, Wenjun
;
Fang, Jie
;
Ma, Shengzhou
Adobe PDF(8221Kb)
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浏览/下载:221/5
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提交时间:2024/04/26
DNA sequences
Gene encoding
Molecular dynamics
Polysaccharides
Direct identifications
DNA Sequencing
Glycan structures
Glycans
Inherent complexity
Micromolar concentration
Peptide detection
Research areas
Simple++
α-hemolysin
Mapping the Acetylamino and Carboxyl Groups on Glycans by Engineered α-Hemolysin Nanopores
期刊论文
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 卷号: 145, 期号: 34, 页码: 18812-18824
作者:
Xia, Bingqing
;
Fang, Jie
;
Ma, Shengzhou
;
Ma, Mengyao
;
Yao, Guangda
Adobe PDF(6885Kb)
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浏览/下载:267/2
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提交时间:2023/09/22
Amino acids
Blood
Glucose
Molecular dynamics
Polysaccharides
Acetamido groups
Analytes
Arginine mutations
Biological functions
Biological macromolecule
Carboxyl groups
Direct identifications
Glycans
Structural complexity
α-hemolysin
Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation
期刊论文
THERANOSTICS, 2022, 卷号: 12, 期号: 11
作者:
Guo, Ren
;
Jia, Xiaohui
;
Ding, Zhenbin
;
Wang, Gang
;
Jiang, Mengmeng
Adobe PDF(7399Kb)
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收藏
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浏览/下载:357/0
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提交时间:2022/08/15
Mixed lineage kinase domain-like protein
MLKL
liver fibrosis
liver parenchymal cells
hepatocyte
hepatic stellate cells
necroptosis
Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution
期刊论文
ADVANCED SCIENCE, 2021, 卷号: 8, 期号: 8, 页码: #VALUE!
作者:
Adobe PDF(6992Kb)
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浏览/下载:325/1
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提交时间:2021/04/01
dry powder inhalation
fluorescence‐
micro optical sectioning tomography
inhaled materials
pulmonary drug delivery
three‐
dimensional rendering
High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice
期刊论文
NATIONAL SCIENCE REVIEW, 2019, 卷号: 6, 期号: 6, 页码: 1223-1238
作者:
Zhang, Xiaochuan
;
Yin, Xianzhen
;
Zhang, Jingjing
;
Li, Anan
;
Gong, Hui
Adobe PDF(7719Kb)
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收藏
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浏览/下载:509/0
|
提交时间:2020/02/28
Micro-Optical Sectioning Tomography
image optimization
Alzheimer's disease
impaired hippocampal vasculature
virtual vascular endoscopy
Succinate-acetate permease from Citrobacter koseri is an anion channel that unidirectionally translocates acetate
期刊论文
CELL RESEARCH, 2018, 卷号: 28, 期号: 6, 页码: 644-654
作者:
Qiu, Biao
;
Xia, Bingqing
;
Zhou, Qingtong
;
Lu, Yan
;
He, Miaomiao
Adobe PDF(3278Kb)
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浏览/下载:941/5
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提交时间:2018/07/04
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