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浏览/检索结果: 共138条，第1-10条 帮助

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Triptolide-based cleavable antibody-drug conjugates for pancreatic cancer 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 295
作者:  Wang, Huihui;  Huangfu, Shangwei;  Wei, Ding;  Sun, Ziyu;  Wu, Yifan
收藏  |  浏览/下载：1/0  |  提交时间：2025/06/17
Discovery of novel and highly potent anticancer agents enabled by selenium scanning of noscapine 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 293
作者:  Li, Defeng;  Shen, Shuting;  Liu, Chuanxu;  Guo, Tingyu;  Liu, Yuhuan
Adobe PDF(19864Kb)  |  收藏  |  浏览/下载：23/4  |  提交时间：2025/05/26
Heterocycle-fused phenylcyclohexylamines as novel multi-target antagonists of N-methyl-D-aspartate (NMDA) receptor and monoamine transporter for treating depression 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 291
作者:  Zheng, Fuqiang
Adobe PDF(10409Kb)  |  收藏  |  浏览/下载：97/21  |  提交时间：2025/04/10
Structural Optimization of Next-Generation TRK Inhibitors against Acquired Drug Resistance Mutations for the Treatment of Solid Tumors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2025
作者:  Xu, Zichao;  Liu, Yueling;  Wang, Peng;  Peng, Xia;  Cheng, Jiawei
Adobe PDF(5181Kb)  |  收藏  |  浏览/下载：34/1  |  提交时间：2025/05/20
Identification of a RANKL/TNF-α Dual-Inhibitor as a Potential Disease-Modifying Agent for the Treatment of Knee Osteoarthritis 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 10, 页码: 10216-10237
作者:  Shao, Zhengguang;  Wang, Tianqi;  Yan, Xueming;  Ning, Ruonan;  Xu, Xing
Adobe PDF(8900Kb)  |  收藏  |  浏览/下载：19/2  |  提交时间：2025/05/16
Discovery of 3‑(Fluoro-imidazolyl)pyridazine Derivatives as Potent STING Agonists with Antitumor Activity 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 10, 页码: 9864-9885
作者:  Hou, Hui;  Zhou, Jingyi;  Sui, Qibang;  Zhang, Changfa;  Su, Zhaoming
Adobe PDF(9996Kb)  |  收藏  |  浏览/下载：23/5  |  提交时间：2025/05/15
Discovery of Highly Potent and Selective EZH2 Covalent Inhibitors via Incorporating Basic Amines 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 10, 页码: 10365-10383
作者:  Zhang, Yi;  Shi, Qiongyu;  Fang, Wei;  Liu, Li;  Yang, Hong
Adobe PDF(4720Kb)  |  收藏  |  浏览/下载：11/1  |  提交时间：2025/05/20
Conformational restriction enables discovering a series of chroman derivatives as potent and selective Nav1.8 inhibitors with improved pharmacokinetic properties 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 293, 页码: 117697
作者:  
Adobe PDF(4737Kb)  |  收藏  |  浏览/下载：16/4  |  提交时间：2025/05/20
D-morphinan analogs with favorable pharmacokinetic profiles as dual-acting antidepressants (vol 287, 117349, 2025) 其他
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025-05-05, 卷号: 289
作者:  Ji, Jing;  Hu, Zhengtao;  Zheng, Fuqiang;  Zheng, Jiefang;  Cheng, Jiaxin
收藏  |  浏览/下载：35/0  |  提交时间：2025/04/14
Expanding the utilization of binding pockets proves to be effective for noncovalent small molecule inhibitors against SARS-CoV-2 Mpro 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 289
作者:  Yang, Qi;  Huang, Xupeng;  Zhang, Hongbo;  Sun, Jing;  Tang, Jielin
Adobe PDF(5890Kb)  |  收藏  |  浏览/下载：98/9  |  提交时间：2025/04/07
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