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Deuterium substitution at the intolerable site as a strategy to mitigate the toxicity of camptothecin derivatives 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296
作者:  Yu, Xianqiang;  Sun, Ziyu;  Liu, Jing;  Huangfu, Shangwei;  Cheng, Qi
Adobe PDF(11608Kb)  |  收藏  |  浏览/下载：15/4  |  提交时间：2025/07/07
Triptolide-based cleavable antibody-drug conjugates for pancreatic cancer 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 295
作者:  Wang, Huihui;  Huangfu, Shangwei;  Wei, Ding;  Sun, Ziyu;  Wu, Yifan
Adobe PDF(9152Kb)  |  收藏  |  浏览/下载：22/4  |  提交时间：2025/06/17
Discovery of novel and highly potent anticancer agents enabled by selenium scanning of noscapine 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 293
作者:  Li, Defeng;  Shen, Shuting;  Liu, Chuanxu;  Guo, Tingyu;  Liu, Yuhuan
Adobe PDF(19864Kb)  |  收藏  |  浏览/下载：46/9  |  提交时间：2025/05/26
Heterocycle-fused phenylcyclohexylamines as novel multi-target antagonists of N-methyl-D-aspartate (NMDA) receptor and monoamine transporter for treating depression 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 291
作者:  Zheng, Fuqiang;  Hu, Zhengtao;  Chen, Hai;  Cheng, Jiaxin;  Hou, Qiongqiong
Adobe PDF(10409Kb)  |  收藏  |  浏览/下载：112/21  |  提交时间：2025/04/10
Conformational restriction enables discovering a series of chroman derivatives as potent and selective Nav1.8 inhibitors with improved pharmacokinetic properties 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 293, 页码: 117697
作者:  Li, Na;  Wang, Linlin;  Hu, Xinyuan;  Xu, Haiyan;  Yang, Bowen
Adobe PDF(4737Kb)  |  收藏  |  浏览/下载：27/4  |  提交时间：2025/05/20
D-morphinan analogs with favorable pharmacokinetic profiles as dual-acting antidepressants (vol 287, 117349, 2025) 其他
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025-05-05, 卷号: 289
作者:  Ji, Jing;  Hu, Zhengtao;  Zheng, Fuqiang;  Zheng, Jiefang;  Cheng, Jiaxin
收藏  |  浏览/下载：43/0  |  提交时间：2025/04/14
Expanding the utilization of binding pockets proves to be effective for noncovalent small molecule inhibitors against SARS-CoV-2 Mpro 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 289
作者:  Yang, Qi;  Huang, Xupeng
Adobe PDF(5890Kb)  |  收藏  |  浏览/下载：106/10  |  提交时间：2025/04/07
Structure-activity relationship analysis of meta-substituted N-cyclopropylmethyl-nornepenthones with mixed KOR/MOR activities 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 289
作者:  Tang, Siyuan;  Hu, Shuyang;  Feng, Lijing;  Kong, Linghui;  Gui, Jiangwen
Adobe PDF(2887Kb)  |  收藏  |  浏览/下载：58/1  |  提交时间：2025/03/25
D-morphinan analogs with favorable pharmacokinetic profiles as dual-acting antidepressants 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 287
作者:  Ji, Jing;  Hu, Zhengtao;  Zheng, Fuqiang;  Zheng, Jiefang;  Cheng, Jiaxin
Adobe PDF(7212Kb)  |  收藏  |  浏览/下载：86/3  |  提交时间：2025/03/10
Exploiting synthetic lethality in PDAC with antibody drug conjugates and ATR inhibition 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 286
作者:  Li, Tao;  Yu, Xianqiang;  Wan, Xinyao;  Liu, Jing;  Zheng, Jie
Adobe PDF(10464Kb)  |  收藏  |  浏览/下载：164/20  |  提交时间：2025/02/17
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