消息
×
loading..
中文版 | English

个人主页

关键词云

成果统计

合作作者[TOP 5]

  • Gu, Tian-Peng

    合作成果数：3

  • 李劲松

    合作成果数：2

  • Guo, Fan

    合作成果数：2

  • Hu, Jia-Lei

    合作成果数：2

  • Li, Bin-Zhong

    合作成果数：2
徐国良 中科院特聘教授
所在学院： 生命科学与技术学院
职务： --
研究方向： 表观遗传调控（中科院上海生命科学研究院生物化学与细胞生物学研究所研究员）
备注： --
徐国良

研究内容

实验室致力于探索：DNA甲基化谱式是如何在胚胎发育早期建立起来的？是否存在新的碱基修饰形式？胚胎干细胞与成体干细胞自我更新与分化是如何达到平衡的？哪些因素导致了 这一平衡的改变而导致肿瘤和疾病发生？对表观遗传信息调控的研究将有助于了解生长发育与疾病发生发展的分子机理，为维护人类健康尤其是再生医学的技术开发提供理论依据。

科研成果

10 17171 3720 3561 0 8
Items Views Downloads TC[WOS] TC[CSCD] H-index
排序方式：
 [1] Qin, Zhen.,Yue, Meiting.,Tang, Shijie.,Wu, Fengying.,Sun, Honghua.,...&Ji, Hongbin.(2024).EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation.JOURNAL OF EXPERIMENTAL MEDICINE,221(3).浏览/下载:357/1; 被引[WOS]:6; IF:12.6/14.1评论推荐收藏
 [2] Chen, Hui.,Yang, Qing-Lin.,Xu, Jia-Xi.,Deng, Xuan.,Zhang, Yun-Jie.,...&Huang, Kai-Yao.(2023).Efficient methods for multiple types of precise gene-editing in Chlamydomonas.PLANT JOURNAL,115(3),846-865.浏览/下载:304/0; 被引[WOS]:14; IF:6.2/7.1评论推荐收藏
 [3] Dai, Hai-Qiang.,Wang, Bang-An.,Yang, Lu.,Chen, Jia-Jia.,Zhu, Guo-Chun.,...&Xu, Guo-Liang.(2016).TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling.NATURE,538(7626),528-+.浏览/下载:648/2; 被引[WOS]:151; IF:50.5/54.4评论推荐收藏
 [4] Xue, Jian-Huang.,Xu, Gui-Fang.,Gu, Tian-Peng.,Chen, Guo-Dong.,Han, Bin-Bin.,...&Du, Ya-Rui.(2016).Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation.JOURNAL OF BIOLOGICAL CHEMISTRY,291(2),731-738.浏览/下载:2777/525; 被引[WOS]:29; IF:4.0/4.4评论推荐收藏
 [5] Li, Zheng.,Gu, Tian-Peng.,Weber, Alain R..,Shen, Jia-Zhen.,Li, Bin-Zhong.,...&Xu, Guo-Liang.(2015).Gadd45a promotes DNA demethylation through TDG.NUCLEIC ACIDS RESEARCH,43(8),3986-3997.浏览/下载:1784/472; 被引[WOS]:69; IF:16.6/16.1评论推荐收藏
 [6] Yang, Hui.,Shi, Linyu.,Wang, Bang-An.,Liang, Dan.,Zhong, Cuiqing.,...&Li, Jinsong.(2012).Generation of Genetically Modified Mice by Oocyte Injection of Androgenetic Haploid Embryonic Stem Cells.CELL,149(3),65-617.浏览/下载:214/0; 被引[WOS]:157; IF:45.5/49.0评论推荐收藏
 [7] Wang, Yang.,Chen, Jiekai.,Hu, Jia-Lei.,Wei, Xi-Xiao.,Qin, Dajiang.,...&Xu, Guo-Liang.(2011).Reprogramming of mouse and human somatic cells by high-performance engineered factors.EMBO REPORTS,12(5),478-478.浏览/下载:801/250; 被引[WOS]:1; IF:6.5/8.3评论推荐收藏
 [8] He, Yu-Fei.,Li, Bin-Zhong.,Li, Zheng.,Liu, Peng.,Wang, Yang.,...&Xu, Guo-Liang.(2011).Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA.SCIENCE,333(6047),133-137.浏览/下载:9319/2248; 被引[WOS]:2147; IF:44.7/50.3评论推荐收藏
 [9] Gu, Tian-Peng.,Guo, Fan.,Yang, Hui.,Wu, Hai-Ping.,Xu, Gui-Fang.,...&Xu, Guo-Liang.(2011).The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes.NATURE,477(7366),606-U136.浏览/下载:270/0; 被引[WOS]:899; IF:50.5/54.4评论推荐收藏
 [10] Hu, Jia-Lei,Zhou, Bo O.,Zhang, Run-Rui,Zhang, Kang-Ling,Zhou, Jin-Qiu,&Xu, Guo-Liang.(2009).The N-terminus of histone H3 is required for de novo DNA methylation in chromatin.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,106(52),22187-22192.浏览/下载:697/222; 被引[WOS]:88; IF:9.4/10.8评论推荐收藏