ACBD3 functions as a scaffold to organize the Golgi stacking proteins and a Rab33b-GAP

doi:10.1002/1873-3468.12780

	ACBD3 functions as a scaffold to organize the Golgi stacking proteins and a Rab33b-GAP
	Yue, Xihua1 ; Bao, Mengjing1 ; Christiano, Romain 2; Li, Siyang1,3,4 ; Mei, Jia1 ; Zhu, Lianhui1 ; Mao, Feifei1 ; Yue, Qiang1,3,4 ; Zhang, Panpan1,3,4 ; Jing, Shuaiyang1,3,4 ; Rothman, James E.1,5 ; Qian, Yi1 ; Lee, Intaek1
	2017-09
发表期刊	FEBS LETTERS (IF:3.0[JCR-2023],3.8[5-Year])
ISSN	1873-3468
卷号	591 期号:18 页码:2793-2802
发表状态	已发表
DOI	10.1002/1873-3468.12780
摘要	Golgin45 plays important roles in Golgi stack assembly and is known to bind both the Golgi stacking protein GRASP55 and Rab2 in the medial-Golgi cisternae. In this study, we sought to further characterize the cisternal adhesion complex using a proteomics approach. We report here that Acyl-CoA binding domain containing 3 (ACBD3) is likely to be a novel binding partner of Golgin45. ACBD3 interacts with Golgin45 via its GOLD domain, while its co-expression significantly increases Golgin45 targeting to the Golgi. Furthermore, ACBD3 recruits TBC1D22, a Rab33b GTPase activating protein (GAP), to a large multi-protein complex containing Golgin45 and GRASP55. These results suggest that ACBD3 may provide a scaffolding to organize the Golgi stacking proteins and a Rab33b-GAP at the medial-Golgi.
关键词	ACBD3 Golgi Golgin45 membrane trafficking Rab-GTPase
收录类别	SCI
语种	英语
资助项目	China Postdoctoral Science foundation[2016M590392]
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS记录号	WOS:000411744200009
出版者	WILEY
WOS关键词	CELL-FREE SYSTEM ; MATRIX PROTEIN ; COMPLEX ; GM130 ; GRASP55 ; GCP60 ; IDENTIFICATION ; REPLICATION ; PROTEOMICS ; CISTERNAE
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/9937
专题	生命科学与技术学院免疫化学研究所生命科学与技术学院_特聘教授组_James E. Rothman组生命科学与技术学院_硕士生
通讯作者	Rothman, James E.; Qian, Yi; Lee, Intaek
作者单位	1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China 2.Harvard Med Sch, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA USA 3.Inst Biochem & Cell Biol, Shanghai, Peoples R China 4.Univ Chinese Acad Sci, Shanghai, Peoples R China 5.Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USA
第一作者单位	免疫化学研究所
通讯作者单位	免疫化学研究所
第一作者的第一单位	免疫化学研究所
推荐引用方式 GB/T 7714	Yue, Xihua,Bao, Mengjing,Christiano, Romain,et al. ACBD3 functions as a scaffold to organize the Golgi stacking proteins and a Rab33b-GAP[J]. FEBS LETTERS,2017,591(18):2793-2802.
APA	Yue, Xihua.,Bao, Mengjing.,Christiano, Romain.,Li, Siyang.,Mei, Jia.,...&Lee, Intaek.(2017).ACBD3 functions as a scaffold to organize the Golgi stacking proteins and a Rab33b-GAP.FEBS LETTERS,591(18),2793-2802.
MLA	Yue, Xihua,et al."ACBD3 functions as a scaffold to organize the Golgi stacking proteins and a Rab33b-GAP".FEBS LETTERS 591.18(2017):2793-2802.