Genetic History of Xinjiang's Uyghurs Suggests Bronze Age Multiple-Way Contacts in Eurasia

doi:10.1093/molbev/msx177

	Genetic History of Xinjiang's Uyghurs Suggests Bronze Age Multiple-Way Contacts in Eurasia
	Feng, Qidi 1,2; Lu, Yan 1; Ni, Xumin 3; Yuan, Kai 1,2; Yang, Yajun 4; Yang, Xiong 1,2; Liu, Chang 1,2; Lou, Haiyi 1; Ning, Zhilin 1,2; Wang, Yuchen 1,2; Lu, Dongsheng 1,2; Zhang, Chao 1,2; Zhou, Ying 1,2; Shi, Meng 1,2; Tian, Lei 1,2; Wang, Xiaoji1,2,5 ; Zhang, Xi1,2,5 ; Li, Jing 1; Khan, Asifullah 1; Guan, Yaqun 6; Tang, Kun 1; Wang, Sijia 1,7; Xu, Shuhua1,2,5,7
	2017-10
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	34 期号:10 页码:2572-2582
发表状态	已发表
DOI	10.1093/molbev/msx177
摘要	The Uyghur people residing in Xinjiang, a territory located in the far west of China and crossed by the Silk Road, are a key ethnic group for understanding the history of human dispersion in Eurasia. Here we assessed the genetic structure and ancestry of 951 Xinjiang's Uyghurs (XJU) representing 14 geographical subpopulations. We observed a southwest and northeast differentiation within XJU, which was likely shaped jointly by the Tianshan Mountains, which traverses from east to west as a natural barrier, and gene flow from both east and west directions. In XJU, we identified four major ancestral components that were potentially derived from two earlier admixed groups: one from the West, harboring European (25-37%) and South Asian ancestries (12-20%), and the other from the East, with Siberian (15-17%) and East Asian (29-47%) ancestries. By using a newly developed method, MultiWaver, the complex admixture history of XJU was modeled as a two-wave admixture. An ancient wave was dated back to similar to 3,750 years ago (ya), which is much earlier than that estimated by previous studies, but fits within the range of dating of mummies that exhibited European features that were discovered in the Tarim basin, which is situated in southern Xinjiang (4,000-2,000 ya); amore recent wave occurred around 750 ya, which is in agreement with the estimate from a recent study using other methods. We unveiled a more complex scenario of ancestral origins and admixture history in XJU than previously reported, which further suggests Bronze Age massive migrations in Eurasia and East-West contacts across the Silk Road.
关键词	Uyghurs Xinjiang Eurasia population structure genetic admixture SNP
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program[2016YFC0906403] ; National Key Research and Development Program[2016YFF0202301]
WOS研究方向	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS记录号	WOS:000411814800011
出版者	OXFORD UNIV PRESS
WOS关键词	GENOME-WIDE ASSOCIATION ; POPULATION-STRUCTURE ; LINKAGE DISEQUILIBRIUM ; ADMIXTURE HISTORY ; TARIM-BASIN ; LANDSCAPE ; DISEASE ; CHINA ; MODEL ; DNA
原始文献类型	Article
引用统计	被引频次：47[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/9933
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_徐书华组生命科学与技术学院_硕士生
通讯作者	Tang, Kun; Wang, Sijia; Xu, Shuhua
作者单位	1.Chinese Acad Sci, Max Planck Independent Res Grp Populat Genom, Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol,Shanghai Inst, Shanghai, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Beijing Jiaotong Univ, Dept Math, Sch Sci, Beijing, Peoples R China 4.Fudan Univ, Sch Life Sci, Shanghai, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 6.Xinjiang Med Univ, Dept Biochem & Mol Biol, Preclin Med Coll, Urumqi, Peoples R China 7.Collaborat Innovat Ctr Genet & Dev, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Feng, Qidi,Lu, Yan,Ni, Xumin,et al. Genetic History of Xinjiang's Uyghurs Suggests Bronze Age Multiple-Way Contacts in Eurasia[J]. MOLECULAR BIOLOGY AND EVOLUTION,2017,34(10):2572-2582.
APA	Feng, Qidi.,Lu, Yan.,Ni, Xumin.,Yuan, Kai.,Yang, Yajun.,...&Xu, Shuhua.(2017).Genetic History of Xinjiang's Uyghurs Suggests Bronze Age Multiple-Way Contacts in Eurasia.MOLECULAR BIOLOGY AND EVOLUTION,34(10),2572-2582.
MLA	Feng, Qidi,et al."Genetic History of Xinjiang's Uyghurs Suggests Bronze Age Multiple-Way Contacts in Eurasia".MOLECULAR BIOLOGY AND EVOLUTION 34.10(2017):2572-2582.