Strong underwater adhesives made by self-assembling multi-protein nanofibres
Zhong, Chao1,2,3,6; Gurry, Thomas1,4; Cheng, Allen A.1,2,3; Downey, Jordan2,3; Deng, Zhengtao1,2,3; Stultz, Collin M.1,4,5; Lu, Timothy K.1,2,3,4
2014
发表期刊NATURE NANOTECHNOLOGY
ISSN1748-3395
卷号9期号:10页码:858-866
发表状态已发表
DOI10.1038/nnano.2014.199
摘要

Many natural underwater adhesives harness hierarchically assembled amyloid nanostructures to achieve strong and robust interfacial adhesion under dynamic and turbulent environments. Despite recent advances, our understanding of the molecular design, self-assembly and structure-function relationships of these natural amyloid fibres remains limited. Thus, designing biomimetic amyloid-based adhesives remains challenging. Here, we report strong and multi-functional underwater adhesives obtained from fusing mussel foot proteins (Mfps) of Mytilus galloprovincialis with CsgA proteins, the major subunit of Escherichia coli amyloid curli fibres. These hybrid molecular materials hierarchically self-assemble into higher-order structures, in which, according to molecular dynamics simulations, disordered adhesive Mfp domains are exposed on the exterior of amyloid cores formed by CsgA. Our fibres have an underwater adhesion energy approaching 20.9mJm-2, which is 1.5 times greater than the maximum of bio-inspired and bio-derived protein-based underwater adhesives reported thus far. Moreover, they outperform Mfps or curli fibres taken on their own and exhibit better tolerance to auto-oxidation than Mfps at pH≥7.0.
© 2014 Macmillan Publishers Limited.

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收录类别EI
资助项目National Science Foundation[] ; National Institutes of Health[0821391] ; Office of Naval Research[N000141310647]
出版者Nature Publishing Group, Houndmills, Basingstoke, Hampshire, RG21 6XS, United Kingdom
EI入藏号20193907473775
EI主题词Adhesion ; Biomimetics ; Escherichia coli ; Fibers ; Glycoproteins ; Hybrid materials ; Molecular dynamics ; Proteins
EI分类号Biology:461.9 ; Physical Chemistry:801.4 ; Organic Compounds:804.1 ; Materials Science:951
原始文献类型Journal article (JA)
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/86848
专题物质科学与技术学院_PI研究组_钟超组
通讯作者Lu, Timothy K.
作者单位1.Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge; MA; 02139-4307, United States
2.Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge; MA; 02139-4307, United States
3.Synthetic Biology Group, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge; MA; 02139-4307, United States
4.Computational and Systems Biology Initiative, Massachusetts Institute of Technology, Cambridge; MA; 02139-4307, United States
5.Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge; MA; 02139-4307, United States
6.School of Physical Science and Technology, ShanghaiTech University, Shanghai; 201210, China
第一作者单位物质科学与技术学院
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Zhong, Chao,Gurry, Thomas,Cheng, Allen A.,et al. Strong underwater adhesives made by self-assembling multi-protein nanofibres[J]. NATURE NANOTECHNOLOGY,2014,9(10):858-866.
APA Zhong, Chao.,Gurry, Thomas.,Cheng, Allen A..,Downey, Jordan.,Deng, Zhengtao.,...&Lu, Timothy K..(2014).Strong underwater adhesives made by self-assembling multi-protein nanofibres.NATURE NANOTECHNOLOGY,9(10),858-866.
MLA Zhong, Chao,et al."Strong underwater adhesives made by self-assembling multi-protein nanofibres".NATURE NANOTECHNOLOGY 9.10(2014):858-866.
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