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Synthesis of N-acyl sulfamates from fluorosulfonates and potassium trimethylsilyloxyl imidates | |
2019-11 | |
发表期刊 | JOURNAL OF ORGANIC CHEMISTRY |
ISSN | 1520-6904 |
EISSN | 1520-6904 |
卷号 | 84期号:23页码:15380-15388 |
发表状态 | 已发表 |
DOI | 10.1021/acs.joc.9b02394 |
摘要 | An efficient and operationally simple method for the synthesis of N-acyl sulfamates from fluorosulfonates and potassium trimethylsilyloxyl imidates as amide precursor is reported. This approach showed broad substrate scope, mild and base-free reaction conditions, short reaction time, and high to excellent yields. Notably, we demonstrated the power of this reaction in the rapid late-stage functionalization of three complex phenol-containing bioactive molecules. Given the prevalence of phenol-containing drugs and building blocks, this method is applicable toward a diversity-oriented drug discovery. |
URL | 查看原文 |
收录类别 | SCI ; SCIE ; EI ; IC ; CCR |
资助项目 | Science and Technology Commission of Shanghai Municipality[16DZ1910200] |
WOS研究方向 | Chemistry |
WOS类目 | Chemistry, Organic |
WOS记录号 | WOS:000502170600036 |
出版者 | AMER CHEMICAL SOC |
WOS关键词 | SUFEX CLICK CHEMISTRY ; NUCLEOSIDE ANTIBIOTICS ; ARYL FLUOROSULFONATES ; MEDIATED HYDROLYSIS ; DRUG DISCOVERY ; PALLADIUM ; PHENOLS ; ACIDS ; SULFOXIMINES ; FLUORIDE |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/80592 |
专题 | 生命科学与技术学院_硕士生 免疫化学研究所_特聘教授组_功能筛选实验室 免疫化学研究所_特聘教授组_抗体设计学实验室 |
通讯作者 | Ma, Peixiang; Xu, Hongtao; Yang, Guang |
作者单位 | 1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China |
第一作者单位 | 免疫化学研究所; 生命科学与技术学院 |
通讯作者单位 | 免疫化学研究所 |
第一作者的第一单位 | 免疫化学研究所 |
推荐引用方式 GB/T 7714 | Zhang, Shuning,Xiong, Huan,Lu, Fengping,et al. Synthesis of N-acyl sulfamates from fluorosulfonates and potassium trimethylsilyloxyl imidates[J]. JOURNAL OF ORGANIC CHEMISTRY,2019,84(23):15380-15388. |
APA | Zhang, Shuning.,Xiong, Huan.,Lu, Fengping.,Ma, Fei.,Gu, Yuang.,...&Yang, Guang.(2019).Synthesis of N-acyl sulfamates from fluorosulfonates and potassium trimethylsilyloxyl imidates.JOURNAL OF ORGANIC CHEMISTRY,84(23),15380-15388. |
MLA | Zhang, Shuning,et al."Synthesis of N-acyl sulfamates from fluorosulfonates and potassium trimethylsilyloxyl imidates".JOURNAL OF ORGANIC CHEMISTRY 84.23(2019):15380-15388. |
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