Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs
Wang, Ying1; Gao, Runze2,3,4; Wu, Jing2; Xiong, Yi-Chun1; Wei, Jia1; Zhang, Sipin2; Yang, Bei5; Chen, Jia2,3; Yang, Li1,2
2019-10-23
Source PublicationGENOME BIOLOGY
ISSN1474-760X
Volume20Issue:1
DOI10.1186/s13059-019-1839-4
AbstractA variety of base editors have been developed to achieve C-to-T editing in different genomic contexts. Here, we compare a panel of five base editors on their C-to-T editing efficiencies and product purity at commonly editable sites, including some human pathogenic C-to-T mutations. We further profile the accessibilities of 20 base editors to all possible pathogenic mutations in silico. Finally, we build the BEable-GPS (Base Editable prediction of Global Pathogenic SNVs) database for users to select proper base editors to model or correct disease-related mutations. The in vivo comparison and in silico profiling catalog the availability of base editors and their broad applications in biomedical studies.
KeywordBase editing Base editor CRISPR Cas Cytidine deaminase Pathogenic mutation
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Indexed BySCI
Language英语
Funding ProjectNSFC[31730111] ; NSFC[31822016] ; NSFC[81872305] ; NSFC[31600654]
WOS Research AreaBiotechnology & Applied Microbiology ; Genetics & Heredity
WOS SubjectBiotechnology & Applied Microbiology ; Genetics & Heredity
WOS IDWOS:000492309200001
PublisherBMC
WOS KeywordDNA ; APOBEC
Original Document TypeArticle
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://kms.shanghaitech.edu.cn/handle/2MSLDSTB/80529
Collection生命科学与技术学院_硕士生
生命科学与技术学院_PI研究组_陈佳组
免疫化学研究所_特聘教授组_抗体结构学实验室
生命科学与技术学院_特聘教授组_杨力组
Corresponding AuthorChen, Jia; Yang, Li
Affiliation1.Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Chinese Acad Sci,Shanghai Inst Biol Sci, CAS Key Lab Computat Biol,CAS MPG Partner Inst Co, Shanghai 200031, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
3.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Wang, Ying,Gao, Runze,Wu, Jing,et al. Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs[J]. GENOME BIOLOGY,2019,20(1).
APA Wang, Ying.,Gao, Runze.,Wu, Jing.,Xiong, Yi-Chun.,Wei, Jia.,...&Yang, Li.(2019).Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs.GENOME BIOLOGY,20(1).
MLA Wang, Ying,et al."Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs".GENOME BIOLOGY 20.1(2019).
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