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Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs | |
2019-10 | |
发表期刊 | GENOME BIOLOGY |
ISSN | 1474-760X |
卷号 | 20期号:1 |
发表状态 | 已发表 |
DOI | 10.1186/s13059-019-1839-4 |
摘要 | A variety of base editors have been developed to achieve C-to-T editing in different genomic contexts. Here, we compare a panel of five base editors on their C-to-T editing efficiencies and product purity at commonly editable sites, including some human pathogenic C-to-T mutations. We further profile the accessibilities of 20 base editors to all possible pathogenic mutations in silico. Finally, we build the BEable-GPS (Base Editable prediction of Global Pathogenic SNVs) database for users to select proper base editors to model or correct disease-related mutations. The in vivo comparison and in silico profiling catalog the availability of base editors and their broad applications in biomedical studies. |
关键词 | Base editing Base editor CRISPR Cas Cytidine deaminase Pathogenic mutation |
URL | 查看原文 |
收录类别 | SCI ; SCIE |
资助项目 | NSFC[31730111] ; NSFC[31822016] ; NSFC[81872305] ; NSFC[31600654] |
WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
WOS记录号 | WOS:000492309200001 |
出版者 | BMC |
WOS关键词 | DNA ; APOBEC |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/80529 |
专题 | 免疫化学研究所_特聘教授组_抗体结构学实验室 生命科学与技术学院_PI研究组_陈佳组 生命科学与技术学院_特聘教授组_杨力组 生命科学与技术学院_硕士生 生命科学与技术学院_博士生 免疫化学研究所_PI研究组_杨贝组 |
共同第一作者 | Gao, Runze; Wu, Jing |
通讯作者 | Chen, Jia; Yang, Li |
作者单位 | 1.Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Chinese Acad Sci,Shanghai Inst Biol Sci, CAS Key Lab Computat Biol,CAS MPG Partner Inst Co, Shanghai 200031, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Wang, Ying,Gao, Runze,Wu, Jing,et al. Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs[J]. GENOME BIOLOGY,2019,20(1). |
APA | Wang, Ying.,Gao, Runze.,Wu, Jing.,Xiong, Yi-Chun.,Wei, Jia.,...&Yang, Li.(2019).Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs.GENOME BIOLOGY,20(1). |
MLA | Wang, Ying,et al."Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs".GENOME BIOLOGY 20.1(2019). |
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