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Detection for disease tipping points by landscape dynamic network biomarkers | |
2019-07 | |
发表期刊 | NATIONAL SCIENCE REVIEW
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ISSN | 2095-5138 |
卷号 | 6期号:4页码:775-785 |
发表状态 | 已发表 |
DOI | 10.1093/nsr/nwy162 |
摘要 | A new model-free method has been developed and termed the landscape dynamic network biomarker (l-DNB) methodology. The method is based on bifurcation theory, which can identify tipping points prior to serious disease deterioration using only single-sample omics data. Here, we show that l-DNB provides early-warning signals of disease deterioration on a single-sample basis and also detects critical genes or network biomarkers (i.e. DNB members) that promote the transition from normal to disease states. As a case study, l-DNB was used to predict severe influenza symptoms prior to the actual symptomatic appearance in influenza virus infections. The l-DNB approach was then also applied to three tumor disease datasets from the TCGA and was used to detect critical stages prior to tumor deterioration using an individual DNB for each patient. The individual DNBs were further used as individual biomarkers in the analysis of physiological data, which led to the identification of two biomarker types that were surprisingly effective in predicting the prognosis of tumors. The biomarkers can be considered as common biomarkers for cancer, wherein one indicates a poor prognosis and the other indicates a good prognosis. |
关键词 | single-sample network dynamic network biomarkers tipping points of complex disease |
URL | 查看原文 |
收录类别 | SCI ; SCIE ; EI ; CSCD |
语种 | 英语 |
资助项目 | JST CREST, Japan[JPMJCR14D2] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000489296400026 |
CSCD记录号 | CSCD:6605641 |
出版者 | OXFORD UNIV PRESS |
EI入藏号 | 20194007489297 |
EI主题词 | Bifurcation (mathematics) ; Deterioration ; Diagnosis ; Tumors ; Viruses |
EI分类号 | Bioengineering and Biology:461 ; Materials Science:951 |
WOS关键词 | CANCER ; CELLS ; PROLIFERATION ; SOX15 |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/80391 |
专题 | 生命科学与技术学院_硕士生 生命科学与技术学院_特聘教授组_陈洛南组 |
通讯作者 | Aihara, Kazuyuki; Chen, Luonan |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci,Key Lab Syst Biol, Shanghai 200031, Peoples R China 2.Shandong Univ Weihai, Sch Math & Stat, Weihai 264209, Peoples R China 3.Univ Tokyo, Inst Ind Sci, Tokyo 1538505, Japan 4.Anhui Univ Finance & Econ, Inst Stat & Appl Math, Bengbu 233030, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 6.Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China 7.Res Ctr Brain Sci & Brain Inspired Intelligence, Shanghai 201210, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Liu, Xiaoping,Chang, Xiao,Leng, Siyang,et al. Detection for disease tipping points by landscape dynamic network biomarkers[J]. NATIONAL SCIENCE REVIEW,2019,6(4):775-785. |
APA | Liu, Xiaoping,Chang, Xiao,Leng, Siyang,Tang, Hui,Aihara, Kazuyuki,&Chen, Luonan.(2019).Detection for disease tipping points by landscape dynamic network biomarkers.NATIONAL SCIENCE REVIEW,6(4),775-785. |
MLA | Liu, Xiaoping,et al."Detection for disease tipping points by landscape dynamic network biomarkers".NATIONAL SCIENCE REVIEW 6.4(2019):775-785. |
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