Keratin 14-high subpopulation mediates lung cancer metastasis potentially through Gkn1 upregulation

doi:10.1038/s41388-019-0889-0

	Keratin 14-high subpopulation mediates lung cancer metastasis potentially through Gkn1 upregulation
	Yao, Shun 1,2,3,4; Huang, Hsin-Yi 1,2,3; Han, Xiangkun 1,2,3; Ye, Yi1,2,3,5 ; Qin, Zhen 1,2,3,4; Zhao, Gaoxiang 1,2,3; Li, Fuming 1,2,3; Hu, Guohong 6,7; Hu, Liang 1,2,3; Ji, Hongbin1,2,3,4,5
	2019-09-05
发表期刊	ONCOGENE (IF:6.9[JCR-2023],7.5[5-Year])
ISSN	0950-9232
卷号	38 期号:36 页码:6354-6369
发表状态	已发表
DOI	10.1038/s41388-019-0889-0
摘要	Metastasis is the leading cause of lung cancer-related death. Elucidating the metastasis process can provide new avenues to inhibit this malignant behavior of cancer cells. Here we found that human lung cancers with high Keratin 14 (K14) expression were associated with nodal metastasis and poor survival. Using the Kras(G12D)/Trp53(L/L) lung cancer mouse model, we confirmed that K14-high cancer cells harbored increased metastatic potential. Mechanistic investigation revealed that Gastrokine 1 (Gknl) expression positively correlated with K14 level, cancer metastasis, and poor patient survival. Importantly, ectopic expression of Gknl enhanced the metastatic capability of K14-low cells in vitro and in vivo, whereas knockdown of Gknl did the opposite, indicating the importance of Gknl in mediating the metastasis of K14-high cells. Further study demonstrated that Gknl expression conferred K14-high cells resistance to anoikis, which is critical for cancer metastasis. Collectively, our findings demonstrate that K14-high cells contribute to lung cancer metastasis potentially through inhibition of anoikis via upregulation of Gknl.
收录类别	SCI ; SCIE
语种	英语
资助项目	China Postdoctoral Science Foundation[2016M601667]
WOS研究方向	Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
WOS记录号	WOS:000485776800003
出版者	NATURE PUBLISHING GROUP
WOS关键词	SQUAMOUS-CELL CARCINOMAS ; 1 INDUCES SENESCENCE ; K-RAS ONCOGENE ; SIGNALING PATHWAY ; MESENCHYMAL TRANSITION ; MOLECULAR SWITCH ; GENE-EXPRESSION ; GASTRIC-MUCOSA ; PROTEIN ; DIFFERENTIATION
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/80243
专题	生命科学与技术学院_硕士生生命科学与技术学院_特聘教授组_季红斌组
通讯作者	Hu, Liang; Ji, Hongbin
作者单位	1.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Innovat Ctr Cell Signaling Network, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200120, Peoples R China 6.Chinese Acad Sci, Inst Hlth Sci, Shanghai Inst Biol Sci, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China 7.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yao, Shun,Huang, Hsin-Yi,Han, Xiangkun,et al. Keratin 14-high subpopulation mediates lung cancer metastasis potentially through Gkn1 upregulation[J]. ONCOGENE,2019,38(36):6354-6369.
APA	Yao, Shun.,Huang, Hsin-Yi.,Han, Xiangkun.,Ye, Yi.,Qin, Zhen.,...&Ji, Hongbin.(2019).Keratin 14-high subpopulation mediates lung cancer metastasis potentially through Gkn1 upregulation.ONCOGENE,38(36),6354-6369.
MLA	Yao, Shun,et al."Keratin 14-high subpopulation mediates lung cancer metastasis potentially through Gkn1 upregulation".ONCOGENE 38.36(2019):6354-6369.