Identification and Application of Gene Expression Signatures Associated with Lifespan Extension

doi:10.1016/j.cmet.2019.06.018

KMS > 生命科学与技术学院 > 特聘教授组 > Philipp Khaitovich组

	Identification and Application of Gene Expression Signatures Associated with Lifespan Extension
	Tyshkovskiy, Alexander 1,2,3; Bozaykut, Perinur 1; Borodinova, Anastasia A.4; Gerashchenko, Maxim, V 1; Ables, Gene P.5; Garratt, Michael 6,7; Khaitovich, Philipp2,8,9,10 ; Clish, Clary B.11; Miller, Richard A.6,7; Gladyshev, Vadim N.1,11
	2019-09-03
发表期刊	CELL METABOLISM
ISSN	1550-4131
卷号	30 期号:3 页码:573-+
发表状态	已发表
DOI	10.1016/j.cmet.2019.06.018
摘要	Several pharmacological, dietary, and genetic interventions that increase mammalian lifespan are known, but general principles of lifespan extension remain unclear. Here, we performed RNA sequencing (RNA-seq) analyses of mice subjected to 8 longevity interventions. We discovered a feminizing effect associated with growth hormone regulation and diminution of sex-related differences. Expanding this analysis to 17 interventions with public data, we observed that many interventions induced similar gene expression changes. We identified hepatic gene signatures associated with lifespan extension across interventions, including upregulation of oxidative phosphorylation and drug metabolism, and showed that perturbed pathways may be shared across tissues. We further applied the discovered longevity signatures to identify new lifespan-extending candidates, such as chronic hypoxia, KU-0063794, and ascorbyl-palmitate. Finally, we developed GENtervention, an app that visualizes associations between gene expression changes and longevity. Overall, this study describes general and specific transcriptomic programs of lifespan extension in mice and provides tools to discover new interventions.
收录类别	SCI ; SCIE
语种	英语
资助项目	Orentreich Foundation for the Advancement of Science, Inc.[ASL20]
WOS研究方向	Cell Biology ; Endocrinology & Metabolism
WOS类目	Cell Biology ; Endocrinology & Metabolism
WOS记录号	WOS:000484370400016
出版者	CELL PRESS
WOS关键词	DRUG-METABOLIZING-ENZYMES ; CALORIC RESTRICTION ; DIETARY RESTRICTION ; NORDIHYDROGUAIARETIC ACID ; SEXUAL-DIMORPHISM ; OXIDATIVE STRESS ; MAMMALIAN TARGET ; CONNECTIVITY MAP ; PROTEIN GENE ; MALE-MICE
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/80011
专题	生命科学与技术学院_特聘教授组_Philipp Khaitovich组
通讯作者	Gladyshev, Vadim N.
作者单位	1.Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Genet, Boston, MA 02115 USA 2.Skolkovo Inst Sci & Technol, Moscow 121205, Russia 3.Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Moscow 119234, Russia 4.Russian Acad Sci, Inst Higher Nervous Act & Neurophysiol, Moscow 117485, Russia 5.Orentreich Fdn Adv Sci Inc, Cold Spring on Hudson, NY USA 6.Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA 7.Univ Michigan, Geriatr Ctr, Ann Arbor, MI 48109 USA 8.CAS MPG Partner Inst Computat Biol, Comparat Biol Grp, 320 Yue Yang Rd, Shanghai 200031, Peoples R China 9.Max Planck Inst Evolutionary Anthropol, Deutsch Pl 6, D-04103 Leipzig, Germany 10.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 11.Broad Inst, Cambridge, MA 02142 USA
推荐引用方式 GB/T 7714	Tyshkovskiy, Alexander,Bozaykut, Perinur,Borodinova, Anastasia A.,et al. Identification and Application of Gene Expression Signatures Associated with Lifespan Extension[J]. CELL METABOLISM,2019,30(3):573-+.
APA	Tyshkovskiy, Alexander.,Bozaykut, Perinur.,Borodinova, Anastasia A..,Gerashchenko, Maxim, V.,Ables, Gene P..,...&Gladyshev, Vadim N..(2019).Identification and Application of Gene Expression Signatures Associated with Lifespan Extension.CELL METABOLISM,30(3),573-+.
MLA	Tyshkovskiy, Alexander,et al."Identification and Application of Gene Expression Signatures Associated with Lifespan Extension".CELL METABOLISM 30.3(2019):573-+.