Engineered Bacillus subtilis biofilms as living glues

doi:10.1016/j.mattod.2018.12.039

	Engineered Bacillus subtilis biofilms as living glues
	Zhang, Chen1,2,3 ; Huang, Jiaofang1 ; Zhang, Jicong1 ; Liu, Suying1,2,4,5 ; Cui, Mengkui1,2,3 ; An, Bolin1 ; Wang, Xinyu1 ; Pu, Jiahua1 ; Zhao, Tianxin1 ; Fan, Chunhai 4,5,6,7; Lu, Timothy K.8; Zhong, Chao1
	2019-09
发表期刊	MATERIALS TODAY (IF:21.1[JCR-2023],25.4[5-Year])
ISSN	1369-7021
卷号	28 页码:40-48
发表状态	已发表
DOI	10.1016/j.mattod.2018.12.039
摘要	The powerful biological adhesion systems of barnacles, mussels, and other marine animals have led to bio-inspired adhesives with impressive performance characteristics. However, lacking the capacities that only cells possess (e.g., self-regeneration, environmental responsiveness, etc.), these artificial materials cannot exploit the full potential of the natural adhesive systems that inspired them. Here, we developed "functional cellular glues" made of Bacillus subtilis biofilms-tightly associated bacteria encased in an extracellular matrix-that contain both an engineered amyloid protein functionalized with a mussel foot protein and an engineered hydrophobin-like protein. We demonstrate proof-of-concept for both tunable adhesion performance via inducible enzymatic modification and for improved adhesion through metal ion-assisted curing. By conceptualizing biofilms themselves-rather than individual material components-as adhesives, we have developed an evolvable engineering platform that opens the door to make smart living glues with dynamic, self-healing, and other previously unattainable material properties.
收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	2016 Open Financial Fund of the Qingdao National Laboratory for Marine Science and Technology[QNLM2016ORP0403]
WOS研究方向	Materials Science
WOS类目	Materials Science, Multidisciplinary
WOS记录号	WOS:000484406100019
出版者	ELSEVIER SCI LTD
WOS关键词	MUSSEL FOOT PROTEINS ; UNDERWATER ADHESIVE ; SURFACE ; COACERVATION ; CHEMISTRY ; STICKING ; FIBERS ; PLAQUE
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/78912
专题	物质科学与技术学院_PI研究组_钟超组生命科学与技术学院_硕士生物质科学与技术学院_硕士生物质科学与技术学院_博士生
通讯作者	Zhong, Chao
作者单位	1.ShanghaiTech Univ, Sch Phys Sci & Technol, Mat & Phys Biol Div, Shanghai 201210, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China 6.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China 7.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med, Shanghai 200240, Peoples R China 8.MIT, Res Lab Elect, Synthet Biol Grp, 77 Massachusetts Ave, Cambridge, MA 02139 USA
第一作者单位	物质科学与技术学院
通讯作者单位	物质科学与技术学院
第一作者的第一单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Zhang, Chen,Huang, Jiaofang,Zhang, Jicong,et al. Engineered Bacillus subtilis biofilms as living glues[J]. MATERIALS TODAY,2019,28:40-48.
APA	Zhang, Chen.,Huang, Jiaofang.,Zhang, Jicong.,Liu, Suying.,Cui, Mengkui.,...&Zhong, Chao.(2019).Engineered Bacillus subtilis biofilms as living glues.MATERIALS TODAY,28,40-48.
MLA	Zhang, Chen,et al."Engineered Bacillus subtilis biofilms as living glues".MATERIALS TODAY 28(2019):40-48.