Engineered Bacillus subtilis biofilms as living glues
Zhang, Chen1,2,3; Huang, Jiaofang1; Zhang, Jicong1; Liu, Suying1,2,4,5; Cui, Mengkui1,2,3; An, Bolin1; Wang, Xinyu1; Pu, Jiahua1; Zhao, Tianxin1; Fan, Chunhai4,5,6,7
2019-09
发表期刊MATERIALS TODAY
ISSN1369-7021
卷号28页码:40-48
发表状态已发表
DOI10.1016/j.mattod.2018.12.039
摘要The powerful biological adhesion systems of barnacles, mussels, and other marine animals have led to bio-inspired adhesives with impressive performance characteristics. However, lacking the capacities that only cells possess (e.g., self-regeneration, environmental responsiveness, etc.), these artificial materials cannot exploit the full potential of the natural adhesive systems that inspired them. Here, we developed "functional cellular glues" made of Bacillus subtilis biofilms-tightly associated bacteria encased in an extracellular matrix-that contain both an engineered amyloid protein functionalized with a mussel foot protein and an engineered hydrophobin-like protein. We demonstrate proof-of-concept for both tunable adhesion performance via inducible enzymatic modification and for improved adhesion through metal ion-assisted curing. By conceptualizing biofilms themselves-rather than individual material components-as adhesives, we have developed an evolvable engineering platform that opens the door to make smart living glues with dynamic, self-healing, and other previously unattainable material properties.
收录类别SCI ; SCIE ; EI
语种英语
资助项目2016 Open Financial Fund of the Qingdao National Laboratory for Marine Science and Technology[QNLM2016ORP0403]
WOS研究方向Materials Science
WOS类目Materials Science, Multidisciplinary
WOS记录号WOS:000484406100019
出版者ELSEVIER SCI LTD
WOS关键词MUSSEL FOOT PROTEINS ; UNDERWATER ADHESIVE ; SURFACE ; COACERVATION ; CHEMISTRY ; STICKING ; FIBERS ; PLAQUE
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/78912
专题物质科学与技术学院_PI研究组_钟超组
生命科学与技术学院_硕士生
物质科学与技术学院_硕士生
物质科学与技术学院_博士生
通讯作者Zhong, Chao
作者单位1.ShanghaiTech Univ, Sch Phys Sci & Technol, Mat & Phys Biol Div, Shanghai 201210, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China
6.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China
7.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med, Shanghai 200240, Peoples R China
8.MIT, Res Lab Elect, Synthet Biol Grp, 77 Massachusetts Ave, Cambridge, MA 02139 USA
第一作者单位物质科学与技术学院
通讯作者单位物质科学与技术学院
第一作者的第一单位物质科学与技术学院
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GB/T 7714
Zhang, Chen,Huang, Jiaofang,Zhang, Jicong,et al. Engineered Bacillus subtilis biofilms as living glues[J]. MATERIALS TODAY,2019,28:40-48.
APA Zhang, Chen.,Huang, Jiaofang.,Zhang, Jicong.,Liu, Suying.,Cui, Mengkui.,...&Zhong, Chao.(2019).Engineered Bacillus subtilis biofilms as living glues.MATERIALS TODAY,28,40-48.
MLA Zhang, Chen,et al."Engineered Bacillus subtilis biofilms as living glues".MATERIALS TODAY 28(2019):40-48.
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