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Structure-Aided Design, Synthesis, and Biological Evaluation of Potent and Selective Non-Nucleoside Inhibitors Targeting Protein Arginine Methyltransferase 5 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 11
作者:  Rong, Deqin;  Zhou, Kaixin;  Fang, Wei;  Yang, Hong;  Zhang, Yi
Adobe PDF(4964Kb)  |  收藏  |  浏览/下载：94/0  |  提交时间：2022/07/01
Novel Sphingosine Kinase 1 Inhibitor Suppresses Growth of Solid Tumor and Inhibits the Lung Metastasis of Triple-Negative Breast Cancer 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 11
作者:  Zhang, Shurui;  Chen, Xiaoxu;  Wu, Chenglin;  Xu, Hui;  Xie, Xiong
Adobe PDF(11423Kb)  |  收藏  |  浏览/下载：145/0  |  提交时间：2022/07/01
Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215
作者:  Gao, Feng;  Chen, Xiaoxu;  Lu, Junyan;  Hu, Shulei;  Xu, Hui
Adobe PDF(2015Kb)  |  收藏  |  浏览/下载：206/0  |  提交时间：2021/04/30
Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 415-422
作者:  Lai, Meng-zhen;  Song, Pei-ran;  Dou, Dou;  Diao, Yan-yan;  Tong, Lin-jiang
Adobe PDF(3317Kb)  |  收藏  |  浏览/下载：196/0  |  提交时间：2020/03/16
Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395
作者:  Diao, Yanyan;  Fang, Xiaoyu;  Song, Peiran;  Lai, Mengzhen;  Tong, Linjiang
Adobe PDF(2955Kb)  |  收藏  |  浏览/下载：299/9  |  提交时间：2019/08/20
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627
作者:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang
Adobe PDF(6587Kb)  |  收藏  |  浏览/下载：350/1  |  提交时间：2018/07/02
7 alpha,8 alpha-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities 期刊论文
FITOTERAPIA, 2018, 卷号: 125, 页码: 174-183
作者:  Zheng, Yuan-Dong;  Bai, Gang;  Tang, Chunping;  Ke, Chang-Qiang;  Yao, Sheng
Adobe PDF(1348Kb)  |  收藏  |  浏览/下载：346/0  |  提交时间：2018/04/11
Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis 期刊论文
CANCER LETTERS, 2018, 卷号: 431, 页码: 150-160
作者:  Zhang, Xiong;  Zheng, Xingling;  Yang, Hong;  Yan, Juan;  Fu, Xuhong
Adobe PDF(3937Kb)  |  收藏  |  浏览/下载：279/1  |  提交时间：2018/08/09
DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo 期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 3, 页码: 398-407
作者:  Li, Meng-yuan;  Lv, Yong-cong;  Tong, Lin-jiang;  Peng, Ting;  Qu, Rong
Adobe PDF(2640Kb)  |  收藏  |  浏览/下载：1055/337  |  提交时间：2017/07/04