ShanghaiTech University Knowledge Management System
| Exploiting mammalian low-complexity domains for liquid-liquid phase separation-driven underwater adhesive coatings | |
| 2019-08 | |
| Source Publication | SCIENCE ADVANCES
 |
| ISSN | 2375-2548 |
| Volume | 5Issue:8 |
| Status | 已发表 |
| DOI | 10.1126/sciadv.aax3155 |
| Abstract | Many biological materials form via liquid-liquid phase separation (LLPS), followed by maturation into a solid-like state. Here, using a biologically inspired assembly mechanism designed to recapitulate these sequential assemblies, we develop ultrastrong underwater adhesives made from engineered proteins containing mammalian low-complexity (LC) domains. We show that LC domain-mediated LLPS and maturation substantially promotes the wetting, adsorption, priming, and formation of dense, uniform amyloid nanofiber coatings on diverse surfaces (e.g., Teflon), and even penetrating difficult-to-access locations such as the interiors of microfluidic devices. Notably, these coatings can be deposited on substrates over a broad range of pH values (3 to 11) and salt concentrations (up to 1 M NaCl) and exhibit strong underwater adhesion performance. Beyond demonstrating the utility of mammalian LC domains for driving LLPS in soft materials applications, our study illustrates a powerful example of how combining LLPS with subsequent maturation steps can be harnessed for engineering protein-based materials. |
| URL | 查看原文 |
| Indexed By | SCI ; SCIE ; EI |
| Language | 英语 |
| Funding Project | Qingdao National Laboratory for Marine Science and Technology[QNLM2016ORP0403] |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| WOS ID | WOS:000482759500023 |
| Publisher | AMER ASSOC ADVANCEMENT SCIENCE |
| EI Keywords | Adhesives ; Beryllium compounds ; Biological materials ; Coatings ; Liquids ; Mammals ; Proteins ; Sodium chloride |
| WOS Keyword | CELL-FREE FORMATION ; GRANULES ; COACERVATION ; AMYLOIDS ; DROPLETS |
| Original Document Type | Article |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/67955 |
| Collection | 物质科学与技术学院_博士生 物质科学与技术学院_PI研究组_钟超组 |
| Corresponding Author | Zhong, Chao |
| Affiliation | 1.ShanghaiTech Univ, Sch Phys Sci & Technol, Mat & Phys Biol Div, Shanghai 201210, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Ceram, Shanghai 200050, Peoples R China 5.Chinese Acad Sci, Interdisciplinary Res Ctr Biol & Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China 6.Jilin Univ, Coll Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Jilin, Peoples R China |
| First Author Affilication | School of Physical Science and Technology |
| Corresponding Author Affilication | School of Physical Science and Technology |
| First Signature Affilication | School of Physical Science and Technology |
| Recommended Citation GB/T 7714 | Cui, Mengkui,Wang, Xinyu,An, Bolin,et al. Exploiting mammalian low-complexity domains for liquid-liquid phase separation-driven underwater adhesive coatings[J]. SCIENCE ADVANCES,2019,5(8). |
| APA | Cui, Mengkui.,Wang, Xinyu.,An, Bolin.,Zhang, Chen.,Gui, Xinrui.,...&Zhong, Chao.(2019).Exploiting mammalian low-complexity domains for liquid-liquid phase separation-driven underwater adhesive coatings.SCIENCE ADVANCES,5(8). |
| MLA | Cui, Mengkui,et al."Exploiting mammalian low-complexity domains for liquid-liquid phase separation-driven underwater adhesive coatings".SCIENCE ADVANCES 5.8(2019). |
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