A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling
Li, Weiping1; Yang, Liguang2; He, Qiang1; Hu, Chaobo1; Zhu, Linying1; Ma, Xiaolong1; Ma, Xueyan1; Bao, Shujie1; Li, Lu1; Chen, Yingying1; Deng, Xing6; Zhang, Xin6; Cen, Jin1; Zhang, Lei1; Wang, Zhong7; Xie, Wei-Fen6; Li, Hong2; Li, Yixue2,3,4,5; Hui, Lijian1,8,9,10
2019-07-03
Source PublicationCELL STEM CELL
ISSN1934-5909
Volume25Issue:1Pages:54-+
Status已发表
DOI10.1016/j.stem.2019.06.008
AbstractFollowing injury, differentiated epithelial cells can serve as a stem cell-independent source for tissue regeneration by undergoing reprogramming into other cell types. The intrinsic molecular basis underlying plasticity of differentiated cells remains largely unaddressed. Here we show that Arid1a, a key component of the SWI/SNF chromatin remodeling complex, controls liver regeneration and gene expression associated with emergence of injury-induced liver-progenitor-like cells (LPLCs). Hepatocyte-specific Arid1a ablation reduces LPLC gene expression in several models of periportal liver injury and impairs liver regeneration, leading to organ dysfunction. Arid1a establishes a permissive chromatin state at LPLC-enriched genes during homeostasis, suggesting it endows hepatocytes with competence to respond to injury-induced signals. Consistently, Arid1a facilitates binding of YAP, a critical regeneration signaling pathway, to LPLC-enriched genes, and Arid1a deletion prevents their YAP-associated induction following injury. Together, these findings provide a framework for studying the contributions of injury-induced LPLCs to periportal liver regeneration.
Indexed BySCI
Language英语
Funding ProjectNational Major Science and Technology Projects of China[2018ZX09711002-009]
WOS Research AreaCell Biology
WOS SubjectCell & Tissue Engineering ; Cell Biology
WOS IDWOS:000473770700008
PublisherCELL PRESS
WOS KeywordSTEM-CELLS ; SWI/SNF COMPLEX ; ATAC-SEQ ; MECHANISMS ; GENE ; EXPRESSION ; PLASTICITY ; ALPHA ; PLURIPOTENCY ; REGENERATION
Original Document TypeArticle
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/61095
Collection生命科学与技术学院_特聘教授组_惠利健组
Corresponding AuthorLi, Hong; Li, Yixue; Hui, Lijian
Affiliation1.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol,Univ Chinese Acad Sci, Shanghai 200031, Peoples R China
2.Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol,Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China
4.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Shanghai 200433, Peoples R China
5.Shanghai Acad Sci & Technol, Shanghai Ctr Bioinformat Technol, Shanghai 201203, Peoples R China
6.Second Mil Med Univ, Changzheng Hosp, Dept Gastroenterol, Shanghai 200003, Peoples R China
7.Univ Michigan, Cardiovasc Res Ctr, Dept Cardiac Surg, Ann Arbor, MI 48109 USA
8.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China
9.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Biores Innovat Ctr, Suzhou 215121, Peoples R China
10.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Li, Weiping,Yang, Liguang,He, Qiang,et al. A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling[J]. CELL STEM CELL,2019,25(1):54-+.
APA Li, Weiping.,Yang, Liguang.,He, Qiang.,Hu, Chaobo.,Zhu, Linying.,...&Hui, Lijian.(2019).A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling.CELL STEM CELL,25(1),54-+.
MLA Li, Weiping,et al."A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling".CELL STEM CELL 25.1(2019):54-+.
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