A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling

doi:10.1016/j.stem.2019.06.008

	A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling
	Li, Weiping 1; Yang, Liguang 2; He, Qiang 1; Hu, Chaobo 1; Zhu, Linying 1; Ma, Xiaolong 1; Ma, Xueyan 1; Bao, Shujie 1; Li, Lu 1; Chen, Yingying 1; Deng, Xing 6; Zhang, Xin 6; Cen, Jin 1; Zhang, Lei 1; Wang, Zhong 7; Xie, Wei-Fen 6; Li, Hong 2; Li, Yixue 2,3,4,5; Hui, Lijian1,8,9,10
	2019-07-03
发表期刊	CELL STEM CELL
ISSN	1934-5909
卷号	25 期号:1 页码:54-+
发表状态	已发表
DOI	10.1016/j.stem.2019.06.008
摘要	Following injury, differentiated epithelial cells can serve as a stem cell-independent source for tissue regeneration by undergoing reprogramming into other cell types. The intrinsic molecular basis underlying plasticity of differentiated cells remains largely unaddressed. Here we show that Arid1a, a key component of the SWI/SNF chromatin remodeling complex, controls liver regeneration and gene expression associated with emergence of injury-induced liver-progenitor-like cells (LPLCs). Hepatocyte-specific Arid1a ablation reduces LPLC gene expression in several models of periportal liver injury and impairs liver regeneration, leading to organ dysfunction. Arid1a establishes a permissive chromatin state at LPLC-enriched genes during homeostasis, suggesting it endows hepatocytes with competence to respond to injury-induced signals. Consistently, Arid1a facilitates binding of YAP, a critical regeneration signaling pathway, to LPLC-enriched genes, and Arid1a deletion prevents their YAP-associated induction following injury. Together, these findings provide a framework for studying the contributions of injury-induced LPLCs to periportal liver regeneration.
收录类别	SCI ; SCIE
语种	英语
资助项目	National Major Science and Technology Projects of China[2018ZX09711002-009]
WOS研究方向	Cell Biology
WOS类目	Cell & Tissue Engineering ; Cell Biology
WOS记录号	WOS:000473770700008
出版者	CELL PRESS
WOS关键词	STEM-CELLS ; SWI/SNF COMPLEX ; ATAC-SEQ ; MECHANISMS ; GENE ; EXPRESSION ; PLASTICITY ; ALPHA ; PLURIPOTENCY ; REGENERATION
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/61095
专题	生命科学与技术学院_特聘教授组_惠利健组
通讯作者	Li, Hong; Li, Yixue; Hui, Lijian
作者单位	1.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol,Univ Chinese Acad Sci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol,Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China 4.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Shanghai 200433, Peoples R China 5.Shanghai Acad Sci & Technol, Shanghai Ctr Bioinformat Technol, Shanghai 201203, Peoples R China 6.Second Mil Med Univ, Changzheng Hosp, Dept Gastroenterol, Shanghai 200003, Peoples R China 7.Univ Michigan, Cardiovasc Res Ctr, Dept Cardiac Surg, Ann Arbor, MI 48109 USA 8.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China 9.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Biores Innovat Ctr, Suzhou 215121, Peoples R China 10.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Li, Weiping,Yang, Liguang,He, Qiang,et al. A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling[J]. CELL STEM CELL,2019,25(1):54-+.
APA	Li, Weiping.,Yang, Liguang.,He, Qiang.,Hu, Chaobo.,Zhu, Linying.,...&Hui, Lijian.(2019).A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling.CELL STEM CELL,25(1),54-+.
MLA	Li, Weiping,et al."A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling".CELL STEM CELL 25.1(2019):54-+.