Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells
Zhang, Qin1; Pan, Ying1; Zeng, Benhua2; Zheng, Xiaojiao1; Wang, Haifang1; Shen, Xueying1,3; Li, Hui1,3; Jiang, Qian4,5; Zhao, Jiaxu6,7; Meng, Zhuo-Xian8
2019-07
发表期刊CELL RESEARCH
ISSN1001-0602
卷号29期号:7页码:516-532
发表状态已发表
DOI10.1038/s41422-019-0190-3
摘要Long-range communication between intestinal symbiotic bacteria and extra-intestinal organs can occur through circulating bacterial signal molecules, through neural circuits, or through cytokines or hormones from host cells. Here we report that Nod1 ligands derived from intestinal bacteria act as signal molecules and directly modulate insulin trafficking in pancreatic beta cells. The cytosolic peptidoglycan receptor Nod1 and its downstream adapter Rip2 are required for insulin trafficking in beta cells in a cell-autonomous manner. Mechanistically, upon recognizing cognate ligands, Nod1 and Rip2 localize to insulin vesicles, recruiting Rab1a to direct insulin trafficking through the cytoplasm. Importantly, intestinal lysozyme liberates Nod1 ligands into the circulation, thus enabling long-range communication between intestinal microbes and islets. The intestine-islet crosstalk bridged by Nod1 ligands modulates host glucose tolerance. Our study defines a new type of inter-organ communication based on circulating bacterial signal molecules, which has broad implications for understanding the mutualistic relationship between microbes and host.
收录类别SCI ; SCIE ; CSCD
语种英语
资助项目CAMS Innovation Fund for Medical Sciences[2016-I2M-4-001]
WOS研究方向Cell Biology
WOS类目Cell Biology
WOS记录号WOS:000473324700005
出版者NATURE PUBLISHING GROUP
WOS关键词BACTERIAL PEPTIDOGLYCAN ; COMMENSAL BACTERIA ; GUT MICROBIOTA ; GLUCOSE ; INFLAMMATION ; RESISTANCE ; QUANTIFICATION ; RECOGNITION ; PROINSULIN ; MECHANISMS
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/61089
专题生命科学与技术学院_特聘教授组_陈正军组
通讯作者Wei, Hong; Liu, Zhihua
作者单位1.Chinese Acad Sci, Key Lab Infect & Immun, Inst Biophys, Beijing 100101, Peoples R China
2.Third Mil Med Univ, Dept Lab Anim Sci, Coll Basic Med Sci, Chongqing 400038, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China
5.Peking Union Med Coll, Beijing 100050, Peoples R China
6.Chinese Acad Sci, State Key Lab Cell Biol, Shanghai Inst Biochem & Cell Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China
7.Chinese Acad Sci, Ctr Excellence Mol Cell Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China
8.Zhejiang Univ, Dept Pathol & Pathophysiol, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China
9.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China
10.Sun Yat Sen Univ, Precis Med Inst, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Qin,Pan, Ying,Zeng, Benhua,et al. Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells[J]. CELL RESEARCH,2019,29(7):516-532.
APA Zhang, Qin.,Pan, Ying.,Zeng, Benhua.,Zheng, Xiaojiao.,Wang, Haifang.,...&Liu, Zhihua.(2019).Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells.CELL RESEARCH,29(7),516-532.
MLA Zhang, Qin,et al."Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells".CELL RESEARCH 29.7(2019):516-532.
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