ShanghaiTech University Knowledge Management System
Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells | |
Zhang, Qin1; Pan, Ying1; Zeng, Benhua2; Zheng, Xiaojiao1; Wang, Haifang1; Shen, Xueying1,3; Li, Hui1,3; Jiang, Qian4,5; Zhao, Jiaxu6,7; Meng, Zhuo-Xian8 | |
2019-07 | |
发表期刊 | CELL RESEARCH |
ISSN | 1001-0602 |
卷号 | 29期号:7页码:516-532 |
发表状态 | 已发表 |
DOI | 10.1038/s41422-019-0190-3 |
摘要 | Long-range communication between intestinal symbiotic bacteria and extra-intestinal organs can occur through circulating bacterial signal molecules, through neural circuits, or through cytokines or hormones from host cells. Here we report that Nod1 ligands derived from intestinal bacteria act as signal molecules and directly modulate insulin trafficking in pancreatic beta cells. The cytosolic peptidoglycan receptor Nod1 and its downstream adapter Rip2 are required for insulin trafficking in beta cells in a cell-autonomous manner. Mechanistically, upon recognizing cognate ligands, Nod1 and Rip2 localize to insulin vesicles, recruiting Rab1a to direct insulin trafficking through the cytoplasm. Importantly, intestinal lysozyme liberates Nod1 ligands into the circulation, thus enabling long-range communication between intestinal microbes and islets. The intestine-islet crosstalk bridged by Nod1 ligands modulates host glucose tolerance. Our study defines a new type of inter-organ communication based on circulating bacterial signal molecules, which has broad implications for understanding the mutualistic relationship between microbes and host. |
收录类别 | SCI ; SCIE ; CSCD |
语种 | 英语 |
资助项目 | CAMS Innovation Fund for Medical Sciences[2016-I2M-4-001] |
WOS研究方向 | Cell Biology |
WOS类目 | Cell Biology |
WOS记录号 | WOS:000473324700005 |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | BACTERIAL PEPTIDOGLYCAN ; COMMENSAL BACTERIA ; GUT MICROBIOTA ; GLUCOSE ; INFLAMMATION ; RESISTANCE ; QUANTIFICATION ; RECOGNITION ; PROINSULIN ; MECHANISMS |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/61089 |
专题 | 生命科学与技术学院_特聘教授组_陈正军组 |
通讯作者 | Wei, Hong; Liu, Zhihua |
作者单位 | 1.Chinese Acad Sci, Key Lab Infect & Immun, Inst Biophys, Beijing 100101, Peoples R China 2.Third Mil Med Univ, Dept Lab Anim Sci, Coll Basic Med Sci, Chongqing 400038, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China 5.Peking Union Med Coll, Beijing 100050, Peoples R China 6.Chinese Acad Sci, State Key Lab Cell Biol, Shanghai Inst Biochem & Cell Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China 7.Chinese Acad Sci, Ctr Excellence Mol Cell Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China 8.Zhejiang Univ, Dept Pathol & Pathophysiol, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China 9.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China 10.Sun Yat Sen Univ, Precis Med Inst, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Qin,Pan, Ying,Zeng, Benhua,et al. Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells[J]. CELL RESEARCH,2019,29(7):516-532. |
APA | Zhang, Qin.,Pan, Ying.,Zeng, Benhua.,Zheng, Xiaojiao.,Wang, Haifang.,...&Liu, Zhihua.(2019).Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells.CELL RESEARCH,29(7),516-532. |
MLA | Zhang, Qin,et al."Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells".CELL RESEARCH 29.7(2019):516-532. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 |
修改评论
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。