Catalytic Redox Chain Ring Opening of Lactones with Quinones To Synthesize Quinone-Containing Carboxylic Acids

doi:10.1021/acs.orglett.9b01672

	Catalytic Redox Chain Ring Opening of Lactones with Quinones To Synthesize Quinone-Containing Carboxylic Acids
	Xu, Xiao-Long1,2 ; Li, Zhi1
	2019-07-05
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	21 期号:13 页码:5078-5081
发表状态	已发表
DOI	10.1021/acs.orglett.9b01672
摘要	Catalytic ring opening of five- to eight-membered lactones with quinones is achieved through a redox chain mechanism. With low loading of a simple metal inflate Lewis acid catalyst and a chain initiator, C-H bonds of many quinones were efficiently functionalized with carboxylic acid-containing side chains. This method also features 100% atom economy and wide substrate scope. A novel route to the anti-asthma drug Seratrodast was developed. Mechanism study suggests that the redox chain reaction likely undergoes a carbocation intermediate.
收录类别	SCI ; SCIE ; IC ; CCR
语种	英语
资助项目	National Natural Science Foundation of China[21673141]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000474795200033
出版者	AMER CHEMICAL SOC
WOS关键词	DERIVATIVES ; OXIDATION ; ALCOHOLS
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/61088
专题	物质科学与技术学院_博士生物质科学与技术学院_PI研究组_李智组
通讯作者	Li, Zhi
作者单位	1.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	物质科学与技术学院
通讯作者单位	物质科学与技术学院
第一作者的第一单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Xu, Xiao-Long,Li, Zhi. Catalytic Redox Chain Ring Opening of Lactones with Quinones To Synthesize Quinone-Containing Carboxylic Acids[J]. ORGANIC LETTERS,2019,21(13):5078-5081.
APA	Xu, Xiao-Long,&Li, Zhi.(2019).Catalytic Redox Chain Ring Opening of Lactones with Quinones To Synthesize Quinone-Containing Carboxylic Acids.ORGANIC LETTERS,21(13),5078-5081.
MLA	Xu, Xiao-Long,et al."Catalytic Redox Chain Ring Opening of Lactones with Quinones To Synthesize Quinone-Containing Carboxylic Acids".ORGANIC LETTERS 21.13(2019):5078-5081.