上海科技大学知识管理系统

Quantitative magnetic resonance imaging (qMRI) offers tissue-specific physical parameters with significant potential for neuroscience research and clinical practice. However, lengthy scan times for 3D multiparametric qMRI acquisition limit its clinical utility. Here, we propose SUMMIT, an innovative imaging methodology that includes data acquisition and an unsupervised reconstruction for simultaneous multiparametric qMRI. SUMMIT first encodes multiple important quantitative properties into highly undersampled k-space. It further leverages implicit neural representation incorporated with a dedicated physics model to reconstruct the desired multiparametric maps without needing external training datasets. SUMMIT delivers co-registered T1, T2, T2 & lowast;, and subvoxel quantitative susceptibility mapping. Extensive simulations, phantom, and in vivo brain imaging demonstrate SUMMIT's high accuracy. Notably, SUMMIT uniquely unravels microstructural alternations in patients with white matter hyperintense lesions with high sensitivity and specificity. Additionally, the proposed unsupervised approach for qMRI reconstruction also introduces a novel zero-shot learning paradigm for multiparametric imaging applicable to various medical imaging modalities.